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Post by yossarian on Mar 13, 2016 14:23:27 GMT -5
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Post by 4allthemarbles on Mar 13, 2016 14:31:08 GMT -5
Well, it's a good thing they are thinking for themselves...
This type of thinking will never cease to amaze me- what study, who paid for it, what insulin did they use, etc. Where is the evidence? Statistics?
The property and pollution of India alone is bad for your health. Never mind the safety issues of walking down the street in any city.
Don't breathe to much air, you could choke.
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Post by dictatorsaurus on Mar 13, 2016 14:37:41 GMT -5
Air pollution, filthy water and over population (breeding) are major problems in India. Inhaled insulin is not what they need to be concerned with.
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Post by agedhippie on Mar 13, 2016 14:53:41 GMT -5
Well, it's a good thing they are thinking for themselves... This type of thinking will never cease to amaze me- what study, who paid for it, what insulin did they use, etc. Where is the evidence? Statistics? They don't pick on Afrezza, they say avoid all insulins as well as drugs (sulfonylureas) that elevate insulin levels. The elevated insulin levels that Type 2 diabetics had due to insulin resistance are a known problem but this is the first time I have seen lungs mentioned I think. The Indian work was supported by Grants GAP-63 from Lady Tata Memorial Trust and MLP 5502 from the Council of Scientific and Industrial Research (Anurag Agrawal); Fellowship Grant from ICMR (Suchita Singh); and NIH Grants HL088029 and HL056470 (Y. S. Prakash). |
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Post by liane on Mar 13, 2016 15:07:22 GMT -5
Unfortunately, they are not distinguishing between the hyperinsulinemia associated with insulin resistance in the T2s, where unchecked high levels of insulin can wreck havoc with every organ system - AND - the the high levels of insulin that should briefly accompany the intake of a meal.
Over time, we should see that Afrezza better controls the glucose spikes, that less basal insulin is needed, and that there are lower levels of insulin in the blood during the time between meals.
It's a pity they did not cite their primary literature, but I suspect this is a very low quality study.
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Post by hankscorpio7 on Mar 13, 2016 15:10:42 GMT -5
Did they mention any effect of ghee on the pulmonary system?
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Post by bioexec25 on Mar 13, 2016 15:14:25 GMT -5
Just a pattern thing, but hasn't there been just the opposite thing praising inhaled insulin in India.
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Post by mnkdfann on Mar 13, 2016 17:40:59 GMT -5
Unfortunately, they are not distinguishing between the hyperinsulinemia associated with insulin resistance in the T2s, where unchecked high levels of insulin can wreck havoc with every organ system - AND - the the high levels of insulin that should briefly accompany the intake of a meal. Over time, we should see that Afrezza better controls the glucose spikes, that less basal insulin is needed, and that there are lower levels of insulin in the blood during the time between meals. It's a pity they did not cite their primary literature, but I suspect this is a very low quality study. I wouldn't be so quick to write it off as a low quality study. "A collaborative study between IGIB, Mayo Clinic College of Medicine, University of Groningen, the Netherlands, University of Copenhagen, Research Centre for Prevention and Health, Denmark, examined and analysed the implications of raised insulin levels against the backdrop of obesity, insulin resistance and emergence of inhaled insulin." This appears to be the paper ajplung.physiology.org/content/early/2016/02/23/ajplung.00091.2015and it was published in a respected, high impact (and American, not Indian) journal ajplung.physiology.org/This is a peer-reviewed scientific journal on physiology published by the American Physiological Society, and is said to be one of the most prestigious such journals in the world. "The American Physiological Society (APS) was founded in 1887 with 28 members ... Today, the APS has 10,500 members, most of whom hold doctoral degrees in medicine, physiology or other health professions. APS's mission then, as now, is to support research, education, and circulation of information in the physiological sciences." |
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Post by liane on Mar 13, 2016 18:06:30 GMT -5
Fair enough - but I just want to read the article. All I see is the abstract. From that little bit, I think they are jumping to conclusions re inhaled insulin.
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Post by taylor810dn on Mar 13, 2016 18:58:13 GMT -5
You might want to mention the article states a fact that PEOPLE BORN IN INDIA HAVE THE LOWEST LUNG FUNCTION IN THE WORLD. Doesn't take a rocket scientist to make a recommendation not to use the lung for drug delivery under those conditions.
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Post by tayl5 on Mar 13, 2016 22:44:46 GMT -5
These studies were done with cell lines and mice, not humans with matched controls. If anyone has access to the actual paper and can work out what the dosage is relative to the Afrezza range that would be helpful. It could be they are dosing at a very high level, similar to the way compounds are labeled as carcinogenic when given at 10-100X the dose anyone would ever encounter just to make the experiment work in a reasonable amount of time.
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Post by mnkdfann on Mar 13, 2016 22:59:22 GMT -5
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Post by peppy on Mar 13, 2016 23:51:10 GMT -5
p.o. insulin might be right for this group. Afrezza isn't approved in India 
Example 11
Oral Administration of Disodium FDKP-Insulin
Capsules containing the FDKP salt and insulin are taken before a meal. The exact dosage is patient-specific, but generally on the order of 10-150 units of insulin is administered per dose.
This oral insulin formulation is used to replace pre-meal insulin injections in patients with diabetes. Additionally, insulin absorbed through the gastrointestinal tract mimics endogenous insulin secretion. Endogenous insulin is secreted by the pancreas into the portal circulation. Thus, the oral route of insulin administration delivers insulin to the site of action in the liver, offering the potential to control glucose levels while limiting systemic exposure to insulin.
Oral insulin delivery using a combination of insulin and the diacid form of FDKP is hindered by the poor solubility of the FDKP diacid in the low PH environment of the gastrointestinal tract. The FDKP salts, however, provide a local buffering effect that facilitates their dissolution in low PH.
patents.justia.com/patent/9259471
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Post by suebeeee1 on Mar 14, 2016 5:04:47 GMT -5
"Never use inhaled insulin. Injecting insulin or giving drugs that make more insulin to curb excess blood sugar can, over the time, result in lung problems," said Agrawal. " Read more at: economictimes.indiatimes.com/articleshow/51342730.cms?utm_source=contentofinterest&utm_medium=text&utm_campaign=cppstWhat this article is saying is nothing more than insulin raised by any means will decrease lung function. According to the news article, even Indian babies are born with high insulin levels. I can understand how a baby, born to a diabetic mother could have high glucose levels... But insulin? I believe this is an article exhorting Indians to eat better and exercise, without interpreting the study as it was intended. Without reading the study itself, this article appears meaningless. |
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Post by lakemann on Mar 14, 2016 8:53:20 GMT -5
Doesn't seem to be affecting share price..  ? |
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