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Post by brotherm1 on Aug 16, 2017 21:48:46 GMT -5
Ha. Comments from dismissed jurors via the above Twitter link.
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Post by mytakeonit on Aug 17, 2017 15:27:32 GMT -5
Hey ... he does look like a dick !!! On nitric oxide ...
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Post by sportsrancho on Aug 20, 2017 14:20:34 GMT -5
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Post by sportsrancho on Aug 21, 2017 11:25:22 GMT -5
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Post by sportsrancho on Aug 29, 2017 17:34:10 GMT -5
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Post by sportsrancho on Aug 29, 2017 17:37:34 GMT -5
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Post by Actual Investor on Aug 29, 2017 18:02:19 GMT -5
Hey Sports, If you want to see bad news on a label, take a scan through this one: they don't know if it's safe and effective in children under 18 but amputation doesn't warrant a black box?
WHAT IS INVOKANA® (canagliflozin)? INVOKANA® is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. INVOKANA® is not for people with type 1 diabetes or with diabetic ketoacidosis (increased ketones in blood or urine). It is not known if INVOKANA® is safe and effective in children under 18 years of age.
IMPORTANT SAFETY INFORMATION INVOKANA® can cause important side effects, including:
Amputations. INVOKANA® may increase your risk of lower-limb amputations. Amputations mainly involve removal of the toe or part of the foot; however, amputations involving the leg, below and above the knee, have also occurred. Some people had more than one amputation, some on both sides of the body. You may be at a higher risk of lower-limb amputation if you: have a history of amputation, have heart disease or are at risk for heart disease, have had blocked or narrowed blood vessels (usually in leg), have damage to the nerves (neuropathy) in the leg, or have had diabetic foot ulcers or sores. Call your doctor right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your doctor may decide to stop your INVOKANA®. Talk to your doctor about proper foot care Dehydration. INVOKANA® can cause some people to become dehydrated (the loss of too much body water), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at higher risk of dehydration if you have low blood pressure, take medicines to lower your blood pressure (including diuretics [water pills]), are on a low sodium (salt) diet, have kidney problems, or are 65 years of age or older Vaginal yeast infection. Women who take INVOKANA® may get vaginal yeast infections. Symptoms include: vaginal odor, white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese), or vaginal itching Yeast infection of the penis (balanitis or balanoposthitis). Men who take INVOKANA® may get a yeast infection of the skin around the penis. Symptoms include: redness, itching, or swelling of the penis; rash of the penis; foul-smelling discharge from the penis; or pain in the skin around penis Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis.
Do not take INVOKANA® if you:
are allergic to canagliflozin or any of the ingredients in INVOKANA®. Symptoms of allergic reaction may include: rash; raised red patches on your skin (hives); or swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing have severe kidney problems or are on dialysis Before you take INVOKANA®, tell your doctor if you have a history of amputation; heart disease or are at risk for heart disease; blocked or narrowed blood vessels (usually in leg); damage to the nerves (neuropathy) of your leg; diabetic foot ulcers or sores; kidney problems; liver problems; history of urinary tract infections or problems with urination; are on a low sodium (salt) diet; are going to have surgery; are eating less due to illness, surgery, or change in diet; pancreas problems; drink alcohol very often (or drink a lot of alcohol in short-term); ever had an allergic reaction to INVOKANA®; or have other medical conditions.
Tell your doctor if you are or plan to become pregnant, are breastfeeding, or plan to breastfeed. INVOKANA® may harm your unborn baby. If you become pregnant while taking INVOKANA®, tell your doctor right away. INVOKANA® may pass into your breast milk and may harm your baby. Do not breastfeed while taking INVOKANA®.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take diuretics (water pills), rifampin (used to treat or prevent tuberculosis), phenytoin or phenobarbital (used to control seizures), ritonavir (Norvir®, Kaletra® – used to treat HIV infection), or digoxin (Lanoxin® – used to treat heart problems).
Possible Side Effects of INVOKANA® INVOKANA® may cause serious side effects, including:
Ketoacidosis (increased ketones in your blood or urine). Ketoacidosis has happened in people who have type 1 or type 2 diabetes, during treatment with INVOKANA®. Ketoacidosis is a serious condition, which may need to be treated in a hospital. Ketoacidosis may lead to death. Ketoacidosis can happen with INVOKANA® even if your blood sugar is less than 250 mg/dL. Stop taking INVOKANA® and call your doctor right away if you get any of the following symptoms: nausea, vomiting, stomach-area pain, tiredness, or trouble breathing Kidney problems. Sudden kidney injury has happened to people taking INVOKANA®. Talk to your doctor right away if you: 1) reduce the amount of food or liquid you drink, if you are sick, or cannot eat or 2) you start to lose liquids from your body from vomiting, diarrhea, or being in the sun too long A high amount of potassium in your blood (hyperkalemia) Serious Urinary Tract Infections: may lead to hospitalization and have happened in people taking INVOKANA®. Tell your doctor if you have signs or symptoms of a urinary tract infection such as: burning feeling while urinating, need to urinate often or right away, pain in the lower part of your stomach (pelvis), or blood in the urine. Some people may also have high fever, back pain, nausea, or vomiting Low blood sugar (hypoglycemia). If you take INVOKANA® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea medicine or insulin may need to be lowered while you take INVOKANA® Signs and symptoms of low blood sugar may include: headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, shaking, or feeling jittery.
Serious allergic reaction. If you have any symptoms of a serious allergic reaction, stop taking INVOKANA® and call your doctor right away or go to the nearest hospital emergency room.
Broken Bones (fractures): Bone fractures have been seen in patients taking INVOKANA®. Talk to your doctor about factors that may increase your risk of bone fracture.
The most common side effects of INVOKANA® include: vaginal yeast infections and yeast infections of the penis; changes in urination, including urgent need to urinate more often, in larger amounts, or at night.
Tell your doctor if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Janssen Scientific Affairs, LLC at 1-800-526-7736.
Please see full Product Information, including Boxed Warning, and Medication Guide for INVOKANA®.
Canagliflozin is licensed from Mitsubishi Tanabe Pharma Corporation.
Trademarks are those of their respective owners.
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Post by Actual Investor on Aug 29, 2017 20:20:41 GMT -5
It'a interesting that VDEX shows that there is a black box warning on their website for Invokana. I copied the information in my previous post from the Invokana website. I'm assuming that VDEX is correct and the manufacturer is behind in posting updates?
"Invokana has recently received a Black Box warning for increased risk of
lower extremity amputations."
As an older pre-diabetic, I don't think Invokana is going to be on my list of preferred drugs when the time comes.
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Post by sportsrancho on Aug 29, 2017 20:24:46 GMT -5
It'a interesting that VDEX shows that there is a black box warning on their website for Invokana. I copied the information in my previous post from the Invokana website. I'm assuming that VDEX is correct and the manufacturer is behind in posting updates? "Invokana has recently received a Black Box warning for increased risk of lower extremity amputations." As an older pre-diabetic, I don't think Invokana is going to be on my list of preferred drugs when the time comes. I just saw a lawsuit for it advertised on CNBC during a commercial break.
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Post by sayhey24 on Aug 30, 2017 7:11:15 GMT -5
At the BeyondA1c forum Dr. Ralph DeFronzo mentioned about so many people loosing toes on ALL the SGLT-2s. Its just not Invokona. IMO, if you have a friend on an SGLT-2 get them off. DeFronzo pretty much said the same thing.
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Post by derek2 on Aug 30, 2017 8:11:27 GMT -5
It'a interesting that VDEX shows that there is a black box warning on their website for Invokana. I copied the information in my previous post from the Invokana website. I'm assuming that VDEX is correct and the manufacturer is behind in posting updates? "Invokana has recently received a Black Box warning for increased risk of lower extremity amputations." As an older pre-diabetic, I don't think Invokana is going to be on my list of preferred drugs when the time comes.I just saw a lawsuit for it advertised on CNBC during a commercial break. In related news, I've become involved in an effort to bring down foot / toe amputations among Nova Scotian homeless folk by 50%. Probably a 5 - 10 year commitment, and one that won't magically show instant success, but a worthy hill to climb. Trying to make a difference instead of just complaining. Homeless people are over-represented in the incidence of diabetes and in the most severe complications, as well. Compliance is a big issue, as many have neither the financial nor cognitive resources to reverse microvascular 7 nerve damage and foot ulceration once it strikes. 25% of homeless people wear shoes that are at least one size too small, leading to blisters, bunions, hammer toe, and even poorer circulation. We have a database with proper shoe sizes, widths and types (for some, hiking boots are a better choice, for example) for a large proportion of homeless people in Nova Scotia, gathered by a professional shoe fitter who was doing this as one-on-one service for the last 5 years. We have a "Bowling shoe" cubby system at a number of shelters and service centers where folks who have been fitted can get a shoe and socks in their size immediately to replace ill-fitting or worn out shoes. The shoes are overstock from a couple of manufacturers who would have been shredding them otherwise. Get the feet dry and prevent ulcers. Next step - research, develop, and provide easy-to-use information on maintaining glycemic control on a budget. That next step will be challenging to get traction on... If people are interested, I can start a thread under "Articles" or "Off Topic" to bring together info about diabetic foot care and treating those on the margins. I bet others could be good sources of info as well.
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Post by peppy on Aug 30, 2017 8:20:56 GMT -5
I just saw a lawsuit for it advertised on CNBC during a commercial break. In related news, I've become involved in an effort to bring down foot / toe amputations among Nova Scotian homeless folk by 50%. Probably a 5 - 10 year commitment, and one that won't magically show instant success, but a worthy hill to climb. Trying to make a difference instead of just complaining. Homeless people are over-represented in the incidence of diabetes and in the most severe complications, as well. Compliance is a big issue, as many have neither the financial nor cognitive resources to reverse microvascular 7 nerve damage and foot ulceration once it strikes. 25% of homeless people wear shoes that are at least one size too small, leading to blisters, bunions, hammer toe, and even poorer circulation. We have a database with proper shoe sizes, widths and types (for some, hiking boots are a better choice, for example) for a large proportion of homeless people in Nova Scotia, gathered by a professional shoe fitter who was doing this as one-on-one service for the last 5 years. We have a "Bowling shoe" cubby system at a number of shelters and service centers where folks who have been fitted can get a shoe and socks in their size immediately to replace ill-fitting or worn out shoes. The shoes are overstock from a couple of manufacturers who would have been shredding them otherwise. Get the feet dry and prevent ulcers. Next step - research, develop, and provide easy-to-use information on maintaining glycemic control on a budget. That next step will be challenging to get traction on... If people are interested, I can start a thread under "Articles" or "Off Topic" to bring together info about diabetic foot care and treating those on the margins. I bet others could be good sources of info as well. population Nova Scotia 2017; 947,284 people.
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Post by sportsrancho on Sept 4, 2017 14:11:33 GMT -5
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Post by falconquest on Sept 4, 2017 17:01:22 GMT -5
Oh sure Sports, pull out the cute puppies. Works every time!
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Post by sportsrancho on Sept 6, 2017 18:34:49 GMT -5
😜
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