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Post by sayhey24 on Aug 23, 2017 18:56:02 GMT -5
Mango - that FOIA request was BRILLIANT!!! Got some for all the orals? It would be a nice "trade study" in spreadsheet format comparing afrezza to all other T2 meds.
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Post by brotherm1 on Aug 23, 2017 20:25:41 GMT -5
"Of course the adverse events should be taken with a grain of salt. Things are reported as possible connections that certainly have no proof of a causal link...." Take those adverse events Mango posted with a grain of salt??? Seems to me you could use all the salt in the world and it would not change what jumps out and smacks right in the face. I do greatly appreciate your intelligent discussions but I see no reason to downplay what looks obvious; at least without somehow first showing significant contrasting reports, if at all even possible. Obviously a lot of effort was involved in obtaining and displaying those reports and I think to say they should be taken with a grain of salt without first providing evidence as strong to the contrary is a slap in the face either just to push buttons or just for the sake of being argumentative. Just my two cents.
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Post by sportsrancho on Aug 23, 2017 20:46:05 GMT -5
People loving Mango:-) Aug. 23 at 5:05 PM mannontop2 @bigcheeze I've read over the years..It truly disturbs me.My sister has been overdosed on it for years..lost her hair, heart issues, etc ![:(](//storage.proboards.com/forum/images/smiley/sad.png) Bullish Aug. 23 at 4:39 PM mannontop2 $MNKD If you have time go over to PB & read mango's posts on Metformin. Great post by Mango..Metformin scary stuff..IMHO..I will never take. Bullish
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Post by dreamboatcruise on Aug 23, 2017 20:49:36 GMT -5
brotherm1 ... he has a long history of trashing Metformin with claims such as causing dementia that simply can't be backed up by clinical trials. Metformin has been used by a HUGE number of patients for a long time and is really a very safe drug. Some have issues tolerating it, but it is safe. The scare tactics for Metformin are simply not backed up with statistics. It is used by millions not thousands of people and for decades, so of course there are more reported adverse events. The Metformin reports he posted aren't that hard to get. It takes me 1 minute to go there and do the same thing. I had earlier in the thread posted some results I got from that same site for Novolog and Afrezza (I just listed results rather than screenshot). My point is in general that adverse event reports in and of themselves do not at all prove causation. Anyone that knows about these reports would tell you that. I used an example from Afrezza that I think all would agree is highly unlikely to have really been caused by Afrezza. Further, many drugs end up having deaths that result from intentional or unintentional overdoses. It may seem bad that suicide deaths are listed, but any drug with the potential for overdose will likely have that. I'm sure Afrezza will as well as more people use it... though perhaps loading all the cartridges one after the other would seem too tedious. Sorry, but I think whether it is Metformin or Afrezza, reported adverse events must be taken with a grain of salt since by there nature they have no verification that there is a causal link... or in the case of death the causal link can be something other than a safety issue when properly used. What is a "contrasting report"? The FDA doesn't have a reporting system for people that have no issues with a drug. If they did the report for Metformin for "no problems" would be orders of magnitude larger than the adverse event report. The adverse event reports are certainly no secret in the medical community and the medical community overwhelming consensus is that Metformin is safe. Why do I care about Metformin... because if someone doesn't have insurance coverage for Afrezza or can't get a doctor to prescribe it, Metformin is certainly way better than living with dangerously elevated BG.
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