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RLS
Nov 21, 2017 20:12:12 GMT -5
mango likes this
Post by peppy on Nov 21, 2017 20:12:12 GMT -5
isotope? Maybe you meant some other word. Elements have isotopes. compounds don't. some where in his work, it became clear to me he was trying to make a synthetic. anyway, somewhere they tried to mirror image the compound or an element in the compound. It did not work. What is the correct name for a compound/element that goes from Left to right mirror image?
i·so·tope
each of two or more forms of the same element that contain equal numbers of protons but different numbers of neutrons in their nuclei, and hence differ in relative atomic mass but not in chemical properties; in particular, a radioactive form of an element.
Liane! (weehaw)
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Post by derek2 on Nov 21, 2017 20:23:37 GMT -5
I know for a fact that the PDF was on the RLS web server. If you shortened the URL, you were able to access the directory structure. Poor security settings, and no message to visitors that files were confidential / off limits. Along with the PDF were: 1. The "trees" background graphic in various sizes for PCs, phones, and tablets 2. A PDF with instructions for the game "Settlers of Cattan" (I'm not kidding) Now, perhaps RLS changed their idea on what compound they would use for inhalation, but that PDF with the 3 cannabis products (tincture, pill, inhaled) was indeed on the server. I didn't share at the time, since mods asked for people to respect RLS's IP. Without proof, we cannot verify your claims. The URL itself was also not formatted correctly and the entire incident reaks of BS. Which turned out to be the case. Take my statement for what it's worth. The whole argument about the PDF is moot anyway, given the new information. Regardless of the past, it's good to hear from Mike C.'s mouth confirmation of what Receptor is looking to bring to market.
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Post by liane on Nov 21, 2017 20:27:24 GMT -5
peppy: Enantiomer - In chemistry, an enantiomer (/ɪˈnæntiəmər, ɛ-, -tioʊ-/[1] ə-NAN-tee-ə-mər; from Greek ἐνάντιος (enántios), meaning "opposite", and μέρος (méros), meaning "part"), also known as an optical isomer[2] (and archaically termed antipode or optical antipode),[3][4] is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).[2] A single chiral atom or similar structural feature in a compound causes that compound to have two possible structures which are non-superposable, each a mirror image of the other. Each member of the pair is termed an enantiomorph (enantio = opposite ; morph = form); the structural property is termed enantiomerism.
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RLS
Nov 21, 2017 20:29:45 GMT -5
mango likes this
Post by derek2 on Nov 21, 2017 20:29:45 GMT -5
isotope? Maybe you meant some other word. Elements have isotopes. compounds don't. some where in his work, it became clear to me he was trying to make a synthetic. anyway, somewhere they tried to mirror image the compound or an element in the compound. It did not work. What is the correct name for a compound/element that goes from Left to right mirror image?
i·so·tope
each of two or more forms of the same element that contain equal numbers of protons but different numbers of neutrons in their nuclei, and hence differ in relative atomic mass but not in chemical properties; in particular, a radioactive form of an element.
Liane! (weehaw)
peppyWhat you're looking for is stereoisomer, which refers to compounds with the same chemical formula, but different 3-D "twist" to the molecules. Stereoisomers can have different biological activity. Vitamin E, for example has several isomers including d-tocopherol (biologically active) and l-tocopherol (biologically inactive)
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Post by liane on Nov 21, 2017 20:29:54 GMT -5
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Post by derek2 on Nov 21, 2017 20:32:16 GMT -5
Will someone please inform my wife?
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Post by sayhey24 on Nov 21, 2017 20:33:34 GMT -5
Mango - I am still not understanding what has changed. What Mike said and the pdf seem to be in sync. Mike verified the first medical product as a CBD/THC based product.
Derek - with Mike's disclosure today it would seem to me you can now share the pdf again.
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Post by sportsrancho on Nov 21, 2017 20:34:24 GMT -5
I know for a fact that the PDF was on the RLS web server. If you shortened the URL, you were able to access the directory structure. Poor security settings, and no message to visitors that files were confidential / off limits. Along with the PDF were: 1. The "trees" background graphic in various sizes for PCs, phones, and tablets 2. A PDF with instructions for the game "Settlers of Cattan" (I'm not kidding) Now, perhaps RLS changed their idea on what compound they would use for inhalation, but that PDF with the 3 cannabis products (tincture, pill, inhaled) was indeed on the server. I didn't share at the time, since mods asked for people to respect RLS's IP. I talk to somebody also who said yes it was on the server. But what was there was suspect...
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Post by liane on Nov 21, 2017 20:38:03 GMT -5
All I know is that it was on the server, it referenced recreational and medicinal applications, and it referenced oral and inhaled vehicles (of which MNKD would provide the technology for the inhaled mode).
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Post by brotherm1 on Nov 21, 2017 21:09:19 GMT -5
Perhaps it was legit and perhaps their plans have since changed. The recreational market - at least - is now abundant in supply of new inhalation methods (vaping, push button-ignition-one hitters, waxes, oils...).
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RLS
Nov 21, 2017 21:56:48 GMT -5
via mobile
Post by mango on Nov 21, 2017 21:56:48 GMT -5
We can officially acknowledge now that the RLS PDF was completely bunk. I hope whoever made it will refrain from any other attempts to create deception. Mango - what was debunked? If I remember correctly it said RLS was using technosphere THC/CBD for medical and recreational purposes. Mike talked about potentially their first medical formulation. Each targeted use requires a different CBD/TCH formulation. Not having any inside knowledge but based on the players involved I always assumed the recreational products would be sold in Starbucks. "I'll take a Granda, a raspberry scone and a 4 pack of the 8u's." Also, my understanding was they would have more THC than CBD from the extraction process so the left over TCH made sense for the recreational product. Starbucks would have to get a license to sell Cannabis in each of their stores, among other things, and would be responsible for significantly more than coffee after that. I don't think that is a good strategic business move and doesn't have anything to do with Starbucks (Starbucks isn't looking to become a dispensary). People are not going to buy their medicine at Starbucks. There wouldn't be any leftover extract for making recreational products in addition to medical products. Whole plant Cannabis extract requires a significant amount of raw material, and growing enough quantities of Cannabis (under FDA regulations) with consistent cannabinoid and terpene profiles that would be required to make the final composition that is going to be prescribed by a physician and used by a patient, while also producing recreational products with leftover extract, would just be unrealistic and not even plausible. The real estate alone that would be required to grow the Cannabis needed under the eyes of the FDA and DEA just to support a single, specific patient population would be enormous and having leftovers to sell to recreational users would be unrealistic and a complete waste of planet material, money, time, and resources. It's irresponsible. Specific chemovars are used (like single plant chemovars with differing cannabinoid content, like high THC and high CBD content) are used. The desired cannabinoid weight ratios (like THC:CBD) are achieved via mixing these together prior to formulation. Or, one or more chemovar with a defined cannabinoid content can be mixed together. GW Pharma for example controls and processes each chemovar separately and then combines them. If Cannabis is legal recreationally in a state, then very very few individuals would be buying a Cannabis product sold by a pharma company, IMO. People will either grow it themselves or get it from the same source or dispensary they currently do. A respectable and reputable pharmaceutical company should not be associated with selling recreational Cannabis products. That is the day said company is no longer reputable and respected.
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Post by lakers on Nov 21, 2017 22:42:05 GMT -5
A second part in the pipeline is a collaboration called Receptor Life Sciences. That market was focused on the cannabinoid medical-marijuana space, and they'll be looking at a strategy around the 505(b)s for an old product called Marinol. And really, looking at bringing out something going forward in that space for hopefully oncology is what I think the market focus is.
www.inverse.com/article/32466-marinol-synthetic-marijuana-dronabinol-thcmarinol dronabinol synthetic thc marijuana 41 clinical trials Scientists are about to experiment and see how Marinol affects all of these medical conditions. The science behind these studies is surprisingly solid. Many clinical trials are plagued by endpoint changes, where the researchers or pharmaceutical company behind the experiment change things around while the study is still ongoing. A quick scan of some of the Marinol studies reveals very few of these changes, meaning that the claims made by scientists about the drugs are generally backed up by reliable evidence. Back in 1985, the U.S. Food & Drug Administration (FDA) approved a synthetic form of marijuana called Marinol to help cancer patients cope with the nausea caused by their chemotherapy treatments. The drug, also known as dronabinol, is still being studied today. In May, it was found to help reduce the amount of seizures in people with severe cases of epilepsy (though it also gave them diarrhea.) It has also been used to bolster the appetite of people fighting anorexia, both as a standalone disorder or as a symptom of treatments for HIV. Marinol is a synthetic, artificially-developed form of delta-9 THC, the active ingredient in jazz cabbage that is most responsible for getting you high.
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Post by mnholdem on Nov 21, 2017 23:16:41 GMT -5
All I know is that it was on the server, it referenced recreational and medicinal applications, and it referenced oral and inhaled vehicles (of which MNKD would provide the technology for the inhaled mode). I kept a copy (which we pulled after it was published on PB, due to it being a confidential document). The document - bogus or not - was clearly designed to attract investors. In other words, it presented a business plan, including building a manufacturing facility in Canada, but lacked specific details of API to be initially developed. It was a promotional piece meant to entice venture capitalists and private investors. If it was bogus, somebody went to a lot of effort to design it and then intentionally leave it on an insufficiently-protected server, possibly to entice Wall Street into invest in MannKind by creating a sense of legitimacy in regard to RLS. Either way, as a promotional document, it was long on ideas and short on specifics about pipeline priorities at a time when Wall Street advisors were actively pushing their clients to consider start up cannabis companies as potentially lucrative investments.
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RLS
Nov 21, 2017 23:23:18 GMT -5
peppy likes this
Post by mango on Nov 21, 2017 23:23:18 GMT -5
isotope? Maybe you meant some other word. Elements have isotopes. compounds don't. some where in his work, it became clear to me he was trying to make a synthetic. anyway, somewhere they tried to mirror image the compound or an element in the compound. It did not work. What is the correct name for a compound/element that goes from Left to right mirror image?
i·so·tope
each of two or more forms of the same element that contain equal numbers of protons but different numbers of neutrons in their nuclei, and hence differ in relative atomic mass but not in chemical properties; in particular, a radioactive form of an element.
Liane! (weehaw)
The structures and stereochemistry of CBD and Δ9-THC, each of which occurs naturally as its (−)-enantiomer, were elucidated in Raphael Mechoulam's laboratory: in 1963 for CBD and in 1964 for Δ9-THC, when it was first isolated from cannabis. It was also in Mechoulam's laboratory, in 1965, that (±)-Δ9-THC and (±)-CBD were first synthesized, developments that were soon followed by the synthesis of the (+)- and (−)-enantiomers, both of these two cannabinoids and of Δ8-THC. www.ncbi.nlm.nih.gov/pmc/articles/PMC1760722/page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF01959156
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Post by babaoriley on Nov 21, 2017 23:26:26 GMT -5
peppy : Enantiomer - In chemistry, an enantiomer (/ɪˈnæntiəmər, ɛ-, -tioʊ-/[1] ə-NAN-tee-ə-mər; from Greek ἐνάντιος (enántios), meaning "opposite", and μέρος (méros), meaning "part"), also known as an optical isomer[2] (and archaically termed antipode or optical antipode),[3][4] is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).[2] A single chiral atom or similar structural feature in a compound causes that compound to have two possible structures which are non-superposable, each a mirror image of the other. Each member of the pair is termed an enantiomorph (enantio = opposite ; morph = form); the structural property is termed enantiomerism. Palindromic enantiomer - what I call phrases like A TOYOTA They read the same forward and backward, and in a mirror! Discovered back in the 70's, driving in front of a Toyota. Big discovery, trust me!
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