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Post by mnholdem on Nov 21, 2017 23:32:08 GMT -5
WOW
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RLS
Nov 21, 2017 23:39:02 GMT -5
Post by mango on Nov 21, 2017 23:39:02 GMT -5
peppy : Enantiomer - In chemistry, an enantiomer (/ɪˈnæntiəmər, ɛ-, -tioʊ-/[1] ə-NAN-tee-ə-mər; from Greek ἐνάντιος (enántios), meaning "opposite", and μέρος (méros), meaning "part"), also known as an optical isomer[2] (and archaically termed antipode or optical antipode),[3][4] is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).[2] A single chiral atom or similar structural feature in a compound causes that compound to have two possible structures which are non-superposable, each a mirror image of the other. Each member of the pair is termed an enantiomorph (enantio = opposite ; morph = form); the structural property is termed enantiomerism. Palindromic enantiomer - what I call phrases like A TOYOTA They read the same forward and backward, and in a mirror! Discovered back in the 70's, driving in front of a Toyota. Big discovery, trust me! PCP?
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RLS
Nov 22, 2017 4:46:20 GMT -5
kc and peppy like this
Post by mytakeonit on Nov 22, 2017 4:46:20 GMT -5
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Post by drman7 on Nov 22, 2017 6:52:53 GMT -5
Mango - what was debunked? If I remember correctly it said RLS was using technosphere THC/CBD for medical and recreational purposes. Mike talked about potentially their first medical formulation. Each targeted use requires a different CBD/TCH formulation. Not having any inside knowledge but based on the players involved I always assumed the recreational products would be sold in Starbucks. "I'll take a Granda, a raspberry scone and a 4 pack of the 8u's." Also, my understanding was they would have more THC than CBD from the extraction process so the left over TCH made sense for the recreational product. Starbucks would have to get a license to sell Cannabis in each of their stores, among other things, and would be responsible for significantly more than coffee after that. I don't think that is a good strategic business move and doesn't have anything to do with Starbucks (Starbucks isn't looking to become a dispensary). People are not going to buy their medicine at Starbucks. There wouldn't be any leftover extract for making recreational products in addition to medical products. Whole plant Cannabis extract requires a significant amount of raw material, and growing enough quantities of Cannabis (under FDA regulations) with consistent cannabinoid and terpene profiles that would be required to make the final composition that is going to be prescribed by a physician and used by a patient, while also producing recreational products with leftover extract, would just be unrealistic and not even plausible. The real estate alone that would be required to grow the Cannabis needed under the eyes of the FDA and DEA just to support a single, specific patient population would be enormous and having leftovers to sell to recreational users would be unrealistic and a complete waste of planet material, money, time, and resources. It's irresponsible. Specific chemovars are used (like single plant chemovars with differing cannabinoid content, like high THC and high CBD content) are used. The desired cannabinoid weight ratios (like THC:CBD) are achieved via mixing these together prior to formulation. Or, one or more chemovar with a defined cannabinoid content can be mixed together. GW Pharma for example controls and processes each chemovar separately and then combines them. If Cannabis is legal recreationally in a state, then very very few individuals would be buying a Cannabis product sold by a pharma company, IMO. People will either grow it themselves or get it from the same source or dispensary they currently do. A respectable and reputable pharmaceutical company should not be associated with selling recreational Cannabis products. That is the day said company is no longer reputable and respected. After the pdf was introduce soon after the RLS website closed some of its html holes. Maybe a coincidence or not.
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Post by esstan2001 on Nov 22, 2017 7:38:41 GMT -5
peppy : Enantiomer - In chemistry, an enantiomer (/ɪˈnæntiəmər, ɛ-, -tioʊ-/[1] ə-NAN-tee-ə-mər; from Greek ἐνάντιος (enántios), meaning "opposite", and μέρος (méros), meaning "part"), also known as an optical isomer[2] (and archaically termed antipode or optical antipode),[3][4] is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).[2] A single chiral atom or similar structural feature in a compound causes that compound to have two possible structures which are non-superposable, each a mirror image of the other. Each member of the pair is termed an enantiomorph (enantio = opposite ; morph = form); the structural property is termed enantiomerism. Palindromic enantiomer - what I call phrases like A TOYOTA They read the same forward and backward, and in a mirror! Discovered back in the 70's, driving in front of a Toyota. Big discovery, trust me! baba... Ahhheh. So now I will be watching my rear view mirror to validate your theory, But where do I find said vehicles so aptly named? I will now have to go out and do a lot of driving around. Maybe get a job as Uber driver so I can kill 2 birds... oh, wait, don't I need a criminal record to qualify for that job? This ATOYOTA stuff... Yet even more information to make my head spin... the more it spins the more shares I buy- Please make it STOP ! And stop shooting me with that BB gun- it is just annoying enough to make me mad. And what happens when I get mad? I buy more shares... Mn was right, you're no real Exorcist... but you will be the death of me!
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Post by babaoriley on Nov 22, 2017 10:42:08 GMT -5
You see, esstan, if you can't get what you want out of the stock market, you can get what you need elsewhere.
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Post by zuegirdor on Nov 22, 2017 12:39:37 GMT -5
some where in his work, it became clear to me he was trying to make a synthetic. anyway, somewhere they tried to mirror image the compound or an element in the compound. It did not work. What is the correct name for a compound/element that goes from Left to right mirror image?
i·so·tope
each of two or more forms of the same element that contain equal numbers of protons but different numbers of neutrons in their nuclei, and hence differ in relative atomic mass but not in chemical properties; in particular, a radioactive form of an element.
Liane! (weehaw)
peppy What you're looking for is stereoisomer, which refers to compounds with the same chemical formula, but different 3-D "twist" to the molecules. Stereoisomers can have different biological activity. Vitamin E, for example has several isomers including d-tocopherol (biologically active) and l-tocopherol (biologically inactive) AKA "chiral"
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RLS
Nov 22, 2017 12:58:12 GMT -5
Post by dreamboatcruise on Nov 22, 2017 12:58:12 GMT -5
I was going to post a lengthy response but i simply will just disagree with you. The PDF was most definitely spot on and was the first mention anywhere that receptor was involved with cannabinoid research as well as listing the correct leadership team behind the company. Also Mike would only mention the collaboration in the elements that Mannkind is involved in (inhaled cannabinoids). I'm not sure how from one sentence you could extrapolate that RLS is in no capacity pursuing other elements of the marijuana industry. Why would Mike mention that? I would tend to agree with you. It may also be that RLS has changed plans in the meantime. Certainly having Jeff Sessions become head of DOJ might have altered the landscape for a cannabis drug company. Seems a very iffy proposition now to pursue recreational as well as regulated pharma formulations. When that pdf was created it may well have looked like we were headed towards federal legalization of cannabis.
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Post by dreamboatcruise on Nov 22, 2017 13:10:27 GMT -5
In the interview posted today, Mike Castagna finally confirms what RLS is working on. "A second part in the pipeline is a collaboration called Receptor Life Sciences. That market was focused on the cannabinoid medical-marijuana space, and they'll be looking at a strategy around the 505(b)s for an old product called Marinol. And really, looking at bringing out something going forward in that space for hopefully oncology is what I think the market focus is." The active ingredient of MARINOL Capsules is man-made dronabinol (dro-NAB-in-all), also chemically known as tetrahydrocannabinol, or THC. THC is also a naturally occurring component of marijuana. Marinol is sold by AbbVie. Looking at the 505(b) strategy mentioned it seems RLS will be using AbbVie's clinical trials data and already FDA approved drug to push for expedited approval of its own formulation which i assume utilizes this same synthetic THC drug with technosphere technology.
No mention of when MNKD will next get money from RLS? Other than that, this is merely confirming what we basically already knew about the collaboration.
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Post by esstan2001 on Nov 22, 2017 13:58:16 GMT -5
You see, esstan, if you can't get what you want out of the stock market, you can get what you need elsewhere. Oh, now I am REALLLLLY confused. At first, I thought this was going to be an obtuse reference to the Rolling Stones. Evidently I do not even know what I need to look for anymore, nor where else I need to look for it !!!! Lastly, I am left to ponder HOW I am even supposed to look for what I do not know of, nor the whereabouts thereof. LOST in SPACE, on the Jupiter II, maybe looking for ATOYOTA, but without a rear view mirror. I gotta tell'ya, it's rough out here... but I can find some peace and a Quantum of Solace in the little nugget of symmetry you gave me. You're the Best, Baba. Whew, that was a close one...
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Post by kc on Nov 23, 2017 9:09:08 GMT -5
On this Thanksgiving day we all have a lot to be grateful for and thankful for I am reminded of this classic from 1967.
Being that this thread to has turned very philosophical, this is a fitting tune to listen to after you stuff your face with Thanksgiving food today.
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Post by brotherm1 on Nov 23, 2017 10:54:37 GMT -5
That song makes me wonder if I have a severe form of attention deficit disorder.
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Post by sportsrancho on Nov 23, 2017 11:00:06 GMT -5
That song makes me wonder if I have a severe form of attention deficit disorder. OMG I can’t stop laughing. And the problem for me is I get like 20 Twitter notices when I’m trying to watch any video:-)
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RLS
Nov 23, 2017 18:29:40 GMT -5
via mobile
Post by kc on Nov 23, 2017 18:29:40 GMT -5
You noticed.
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Post by me on Nov 25, 2017 8:50:58 GMT -5
You see, esstan, if you can't get what you want out of the stock market, you can get what you need elsewhere. LOST in SPACE, on the Jupiter II, maybe looking for ATOYOTA, but without a rear view mirror. You know, "A Santa Lived As a Devil At NASA."
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