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Post by dreamboatcruise on Apr 30, 2018 17:18:58 GMT -5
TicToc by Bloomberg @tictoc · Apr 21 The U.S. is giving away the $30 billion medical marijuana industry. Because the feds are bogarting the weed, while Israel and Canada are grabbing market share, @joshdean66 reports #tictocnews (link: bloom.bg/2HQjQJx) bloom.bg/2HQjQJx
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Post by mango on Apr 30, 2018 20:07:31 GMT -5
Side note
The safety and efficacy of single synthetic THC compounds, including synthetic THC analogs like Nabilone, are inferior to whole plant Cannabis and whole plant Cannabis extract. A single isolated synthetic THC compound and/or analog can potentially be quite dangerous and bear great risks for potentially producing many negative side effects, possibly irreversible harm. They also lack synergistic components and the therapeutic potential just simply pales in comparison to the whole plant Cannabis and whole plant Cannabis extract.
Single synthetic THC compounds are inferior to whole plant Cannabis and whole plant Cannabis extract for many reasons, and any potential therapeutic benefit that a synthetic single THC molecule potentially has does not outshine its negative and unwanted side effects, potential adverse reactions, negative drug-drug interactions and other potential dangers. Single synthetic THC cannabinoid molecules lack synergistic components, and overall their therapeutic benefit is poor.
A single isolated THC molecule lacks synergistic components. Cannabis has thousands of compounds, it contains over 100 phytocannabinoids, numerous terpenoids and flavonoids, and many more non-cannabinoid compounds—together, these compounds produce synergy (the entourage effect). An example of this would be how CBD works synergetically with THC. One way it does this is it enhances certain therapeutic properties (like for in pain, nausea and vomiting) while dampening some of its less desirable characteristics (fast heart rate, anxiety).
CBD:
- CBD is an endocannabinoid modulator—works to maintain a balance between excess and deficiency (homeostasis)
- CBD works by regulating the physiological balance of a system—it makes adjustments and inhibitions if there is an excess or over activation and promotes up-regulation during a deficiencies
- CBD functions like a buffer to maintain balance (homeostasis)
- CBD functions as both a positive and negative allosteric modulator. This means that CBD alters the receptor binding site to enhance or weaken signal transmissions
- CBD binds to the allosteric site on the CB1 receptor, whereas THC and the endogenous cannabinoids Anadamide and 2-AG bind to an orthosteric site
- CBD produces synergy with THC, enhancing certain therapeutic properties such as with pain, nausea and vomiting etc... while dampening unwanted/undesirable effects such as anxiety and rapid heart rate. CBD is an anti-psychotic and anti-anxiety agent, among others
- CBD has enormous therapeutic potential with: Diabetes, osteoporosis, glaucoma, pain, nausea, stroke, multiple sclerosis, skin diseases and disorders, arthritis, irritable bowel syndrome, fibromyalgia, migraines, obesity, Parkinson’s, traumatic brain injuries, atherosclerosis, arthritis, Alzheimer’s, Huntington’s, nausea, spinal cord injuries, AIDS, asthma, OCD, stress, anxiety, psychosis, alcoholism, addiction, schizophrenia, PTSD, depression, ADHD
I am disappointed in what RLS and MannKind are potentially doing. It is a waste of time and money and ridiculous. That is my opinion.
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Post by uvula on Apr 30, 2018 20:18:27 GMT -5
I'll be nice in case I meet you in person in a few weeks.
It seems silly to be an expert on something that hasn't been developed or tested yet. I'm sure some people thought inhaling insulin was nuts too.
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Post by mango on Apr 30, 2018 20:28:29 GMT -5
I'll be nice in case I meet you in person in a few weeks. It seems silly to be an expert on something that hasn't been developed or tested yet. I'm sure some people thought inhaling insulin was nuts too. Does not matter if it is inhaled. Single synthetic THC molecules and analogs lack synergy, in the case of an inhaled dronabinal which is a synthetic THC compound, it will be inferior to whole plant Cannabis extract.
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Post by mango on Apr 30, 2018 20:31:14 GMT -5
I'll be more than happy to hear your side in person. Not claimig to be an expert but what I posted is true.
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Post by digger on May 1, 2018 8:30:17 GMT -5
I'll be nice in case I meet you in person in a few weeks. It seems silly to be an expert on something that hasn't been developed or tested yet. I'm sure some people thought inhaling insulin was nuts too. Does not matter if it is inhaled. Single synthetic THC molecules and analogs lack synergy, in the case of an inhaled dronabinal which is a synthetic THC compound, it will be inferior to whole plant Cannabis extract. Has RLS really done anything? The address comes up on google maps as a residential home.
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Post by goyocafe on May 1, 2018 8:32:36 GMT -5
Does not matter if it is inhaled. Single synthetic THC molecules and analogs lack synergy, in the case of an inhaled dronabinal which is a synthetic THC compound, it will be inferior to whole plant Cannabis extract. Has RLS really done anything? The address comes up on google maps as a residential home. There’s a carrot garden in the back yard. 🤪
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Post by boca1girl on May 1, 2018 8:36:35 GMT -5
Does not matter if it is inhaled. Single synthetic THC molecules and analogs lack synergy, in the case of an inhaled dronabinal which is a synthetic THC compound, it will be inferior to whole plant Cannabis extract. Has RLS really done anything? The address comes up on google maps as a residential home. MNKD has reported that RLS employes work out of the Danbury facility. MNKD is paid for supporting their R&D efforts.
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Post by akemp3000 on May 1, 2018 9:21:18 GMT -5
For newbies...In October of 2015 Andrea Leone-Bay left the position of Vice President of Pharmaceutical R&D at Mannkind Corporation to become the Chief Scientific Officer of RLS. It's my understanding she continues to work inside Mannkind's Danbury facility. Her name is on many MNKD patents and she has spoken at many industry conferences. While we've heard almost no public results to date, there are many reasons to believe something good is going to come from this and no reason to think she's just wasting her time on a fruitless project. It does seem time to hear a progress report.
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Post by dreamboatcruise on May 1, 2018 11:30:07 GMT -5
For newbies...In October of 2015 Andrea Leone-Bay left the position of Vice President of Pharmaceutical R&D at Mannkind Corporation to become the Chief Scientific Officer of RLS. It's my understanding she continues to work inside Mannkind's Danbury facility. Her name is on many MNKD patents and she has spoken at many industry conferences. While we've heard almost no public results to date, there are many reasons to believe something good is going to come from this and no reason to think she's just wasting her time on a fruitless project. It does seem time to hear a progress report. What are the many reasons to believe there is progress. I can think of only one... that MNKD included them in recent presentations. So pro... they were mentioned, but con it was mentioned without any concrete statement of progress. You mention patents but I don't believe there are any we know of from RLS. The ones listing her were from when she was still employeed at MNKD. If there really are RLS patents then that would be an indicator of progress. BTW... I know it's been speculated here on proboards that Andrea is working out of MNKD Danbury facility, but I thought that was mere speculation. Can you point to a concrete source for that?
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Post by mnholdem on May 1, 2018 11:50:54 GMT -5
For newbies...In October of 2015 Andrea Leone-Bay left the position of Vice President of Pharmaceutical R&D at Mannkind Corporation to become the Chief Scientific Officer of RLS. It's my understanding she continues to work inside Mannkind's Danbury facility. Her name is on many MNKD patents and she has spoken at many industry conferences. While we've heard almost no public results to date, there are many reasons to believe something good is going to come from this and no reason to think she's just wasting her time on a fruitless project. It does seem time to hear a progress report. What are the many reasons to believe there is progress. I can think of only one... that MNKD included them in recent presentations. So pro... they were mentioned, but con it was mentioned without any concrete statement of progress. You mention patents but I don't believe there are any we know of from RLS. The ones listing her were from when she was still employeed at MNKD. If there really are RLS patents then that would be an indicator of progress. BTW... I know it's been speculated here on proboards that Andrea is working out of MNKD Danbury facility, but I thought that was mere speculation. Can you point to a concrete source for that? Oops! Wrong again...
patentscope.wipo.int/search/en/detail.jsf?docId=WO2017185038&recNum=1&office=&queryString=FP%3A%28receptor%2Blife%2Bsciences%29&prevFilter=&sortOption=Pub+Date+Desc&maxRec=6 Pub. No.: WO/2017/185038 International Application No.: PCT/US2017/028953 Publication Date: 26.10.2017 International Filing Date: 21.04.2017 IPC: A61K 31/352 (2006.01), A61K 47/06 (2006.01), A61K 31/197 (2006.01)
Applicants: RECEPTOR LIFE SCIENCES [US/US]; 2578 Constance Dr. W Seattle, WA 98199 (US) Inventors: LEONE-BAY, Andrea; (US). WESNER, Gregory; (US) Agent: WINGER, C., Rachal; (US). WITTKOPP, Cristina, J.; (US) Priority Data: 62/326,490 22.04.2016 US 62/429,544 02.12.2016 US Title (EN) FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS
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Post by dreamboatcruise on May 1, 2018 12:02:21 GMT -5
mnholdem... good to see. At least means they weren't in complete hibernation mode as of a year ago. If you can find me a clinical trial, I might get very excited.
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Post by me on May 1, 2018 12:20:29 GMT -5
What are the many reasons to believe there is progress. I can think of only one... that MNKD included them in recent presentations. So pro... they were mentioned, but con it was mentioned without any concrete statement of progress. You mention patents but I don't believe there are any we know of from RLS. The ones listing her were from when she was still employeed at MNKD. If there really are RLS patents then that would be an indicator of progress. BTW... I know it's been speculated here on proboards that Andrea is working out of MNKD Danbury facility, but I thought that was mere speculation. Can you point to a concrete source for that? Oops! Wrong again...
Say it ain't so, Joe!
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Post by dreamboatcruise on May 1, 2018 12:24:28 GMT -5
Oops! Wrong again...
Say it ain't so, Joe! Normally I'm right simply because I check things before I post. This time I was lazy and didn't go to the patent search site. It happens, but I certainly don't condone that sort of laziness which I see all too often. I'll try harder next time In general I do give warning when I haven't verified something as with this being prefaced by stating it was a belief I had (subject to my recall)... as opposed to stating it as a hard fact.
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Post by akemp3000 on May 1, 2018 15:01:06 GMT -5
Good to see Europe, Africa and Asia included in the states for the patent filing.
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