MNKD Blockbuster Patents: Freedom from Opioid Addiction

[frumenti]

The Federal Government set aside $1 Billion for fight Opioid addiction and Mannkind has two patents 
that reduce unwanted side effects such as addiction to opioids . Here are summaries of Justia patents. I know of no other drugs 
that can do that. All patents must have proof that the invention really works. A few examples included in the patents are listed below.
How many companies need this technology?

Justia Patents owned by MNKD: 9610351 and 9233159



“Current opioid therapy using morphine and like compounds are effective to treat pain but the side effects they produce such as addiction, somnolence, tolerance, respiratory depression, and constipation limit their clinical use.”



“Disclosed are methods and compositions for treating pain that facilitate delivery of the pain medication while reducing unwanted side effects, such as, for example, addiction, somnolence, tolerance, respiratory depression, and constipation, and the like.”



Examples using real patients:

Example 6

A 48 yr. old female patient reports headache pain to her doctor. Following examination of the patient, the doctor prescribes an analgesic composition containing a FDKP/SEQ (D)Phe-(D)Phe-(D)Nle-(D)Arg-NH2 (SEQ ID NO: 2, Compound 2) composition prepared as described in the previous Examples. The analgesic composition is 15% peptide. The analgesic composition is administered with a reusable inhaler calibrated to provide a dose of 5 mg/kg of body weight. The patient reports the elimination of her headache pain.


Example 7

A 22 yr. old male patient undergoing chemotherapy reports stomach pain to his doctor. Following examination of the patient, the doctor prescribes an analgesic composition containing a FDKP/(D)Phe-(D)Phe-(D)Ile-(D)Arg-NH2 (SEQ ID NO: 1, Compound 1) composition prepared as described in the previous Examples. The analgesic composition is 15% peptide. The analgesic composition is administered with a reusable inhaler calibrated to provide a dose of 5 mg/kg of body weight. The patient reports the elimination of his stomach pain.



Example 8

A 63 yr. old female patient reports back pain to her doctor. Following examination of the patient, the doctor prescribes an analgesic composition containing a FDKP/Trp-(D)Pro-Ser-Phe-NH2 (SEQ ID NO: 3, Compound 3), composition prepared as described in the previous Examples. The analgesic composition is 15% peptide. The analgesic composition is administered with a reusable inhaler calibrated to provide a dose of 4 mg/kg of body weight. The patient reports the elimination of her back pain.

[tomtabb]

Does the patent claim explain how it's able to reduce the side effects?

[frumenti]

Yes. You can see the patents by googling Justia pan tents and the patent numbers I listed above.

[tomtabb]

The patent appears to be co-owned by Torrey Pines Institute. It's been six years since Mannkind partnered with them; have there been any developments since?

[tinkusr8215]

how so blockbuster? simple question hoping you have a simple answer.

[frumenti]

All patents must explain how the invention works and provide evidence of it working. You can read the patents by Googling: Justia patents 9610351 and 9233159

[uvula]

I'm not going to bother reading the patents. They are intentionally written to be as difficult to follow as possible. I'm sure I wouldn't understand them even if they were trying to be as clear as possible.

One thing that doesn't add up. If MNKD had a potential cure for the opioid crisis, wouldn't the gov't and groups like the Gates Foundation be all over this? Fast track, etc. But we haven't heard anything for years.

[goyocafe]

Oct 26, 2018 12:03:29 GMT -5 uvula said:

I'm not going to bother reading the patents. They are intentionally written to be as difficult to follow as possible. I'm sure I wouldn't understand them even if they were trying to be as clear as possible.

One thing that doesn't add up. If MNKD had a potential cure for the opioid crisis, wouldn't the gov't and groups like the Gates Foundation be all over this? Fast track, etc. But we haven't heard anything for years.

I’ve read their pain peptide patents and wondered about this for years. The patents make it sound like a godsend and yet it rots on a shelf. smh

[mannmade]

As I recall this was the subject of the Torrey Pines partnership from several years ago. Specifically a non addictive pain killer that could be taken liberally with no side effects nor addiction issues. For some reason it has faded from the conversation.

[mango]

Oct 26, 2018 12:33:25 GMT -5 mannmade said:

As I recall this was the subject of the Torrey Pines partnership from several years ago. Specifically a non addictive pain killer that could be taken liberally with no side effects nor addiction issues. For some reason it has faded from the conversation.

A MannKind/Torrey Pines NCE pain molecule was under Bucket 4 in a slide some time ago. Hope it is one of the 4 that Mike plans to bring forward soon. 

[Deleted]

Oct 26, 2018 12:39:16 GMT -5 mango said:

Oct 26, 2018 12:33:25 GMT -5 mannmade said:

As I recall this was the subject of the Torrey Pines partnership from several years ago. Specifically a non addictive pain killer that could be taken liberally with no side effects nor addiction issues. For some reason it has faded from the conversation.

A MannKind/Torrey Pines NCE pain molecule was under Bucket 4 in a slide some time ago. Hope it is one of the 4 that Mike plans to bring forward soon. 

Broad use for migraines, general pain and oncology?  If so and product effective, would have to be on Mike's list.  Plenty of money available outside of Mannkind to bring a pain wonder drug to market. If as good as claimed without addictive properties, getting $100 mm would be a cakewalk.  Earlier question was critical, why has Mannkind not pursued it?  

[lennymnkd]

If any one question was to be asked to Mike by anyone of us somehow ....CC this might be it 🤞

[mango]

Oct 26, 2018 14:43:57 GMT -5 @scotta said:

Oct 26, 2018 12:39:16 GMT -5 mango said:

A MannKind/Torrey Pines NCE pain molecule was under Bucket 4 in a slide some time ago. Hope it is one of the 4 that Mike plans to bring forward soon. 

Broad use for migraines, general pain and oncology?  If so and product effective, would have to be on Mike's list.  Plenty of money available outside of Mannkind to bring a pain wonder drug to market. If as good as claimed without addictive properties, getting $100 mm would be a cakewalk.  Earlier question was critical, why has Mannkind not pursued it?  

I'd guess because both MannKind and Torrey Pines were broke and MannKind has been in massive debt with no way of affording expensive and lengthy clinical trials etc that a new chemical entity for treating pain will have to go through, and then there is the whole stepping on toes of the likes of Purdue Pharma types whose livelihood is selling opioids, not helping people. They will be taking business away from opium poppy cultivators & opioid manufacturers like Sanofi, who owns a subsidiary dedicated to developing opioids and cultivating opium poppy. 

[Deleted]

Oct 26, 2018 15:28:31 GMT -5 mango said:

Oct 26, 2018 14:43:57 GMT -5 @scotta said:

Broad use for migraines, general pain and oncology?  If so and product effective, would have to be on Mike's list.  Plenty of money available outside of Mannkind to bring a pain wonder drug to market. If as good as claimed without addictive properties, getting $100 mm would be a cakewalk.  Earlier question was critical, why has Mannkind not pursued it?  

I'd guess because both MannKind and Torrey Pines were broke and MannKind has been in massive debt with no way of affording expensive and lengthy clinical trials etc that a new chemical entity for treating pain will have to go through, and then there is the whole stepping on toes of the likes of Purdue Pharma types whose livelihood is selling opioids, not helping people. They will be taking business away from opium poppy cultivators & opioid manufacturers like Sanofi, who owns a subsidiary dedicated to developing opioids and cultivating opium poppy. 

So spin the pain killer into a separate entity.

 

[tinkusr8215]

Oct 26, 2018 11:38:50 GMT -5 frumenti said:

All patents must explain how the invention works and provide evidence of it working. You can read the patents by Googling: Justia patents 9610351 and 9233159

That tells me about the patent. I am asking about the "Blockbuster" part of the patent.