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Post by dh4mizzou on Mar 17, 2019 8:58:36 GMT -5
Just saw a Trulicity commercial and one of the disclaimers was that Trulicity is NOT insulin.
Could MNKD not include a statement that Afrezza is EXACTLY the same insulin your body should produce?
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Post by agedhippie on Mar 17, 2019 9:11:17 GMT -5
Just saw a Trulicity commercial and one of the disclaimers was that Trulicity is NOT insulin. Could MNKD not include a statement that Afrezza is EXACTLY the same insulin your body should produce? The Trulicity statement is smart because it plays on the concerns people have about insulin and insulin as the end of the world. |
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Post by boca1girl on Mar 17, 2019 9:34:52 GMT -5
Just saw a Trulicity commercial and one of the disclaimers was that Trulicity is NOT insulin. Could MNKD not include a statement that Afrezza is EXACTLY the same insulin your body should produce? The Trulicity statement is smart because it plays on the concerns people have about insulin and insulin as the end of the world. Funny about perception. Listen to all the warnings and potential side effects of those “NOT INSULIN” products. I hope someday we have a commercial that shows head to head comparisons of negative side effects between non-insulin products and Afrezza. And don’t bother with a come back that insulin can kill you. Afrezza isn’t your “father’s” insulin and has not killed anyone. |
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Post by dh4mizzou on Mar 17, 2019 9:37:19 GMT -5
Just saw a Trulicity commercial and one of the disclaimers was that Trulicity is NOT insulin. Could MNKD not include a statement that Afrezza is EXACTLY the same insulin your body should produce? The Trulicity statement is smart because it plays on the concerns people have about insulin and insulin as the end of the world. I'm sorry but your concerned criticism act is wearing extremely thin. |
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Post by agedhippie on Mar 17, 2019 11:05:43 GMT -5
The Trulicity statement is smart because it plays on the concerns people have about insulin and insulin as the end of the world. Funny about perception. Listen to all the warnings and potential side effects of those “NOT INSULIN” products. I hope someday we have a commercial that shows head to head comparisons of negative side effects between non-insulin products and Afrezza. And don’t bother with a come back that insulin can kill you. Afrezza isn’t your “father’s” insulin and has not killed anyone. There are a lot of studies out there showing why people resist starting insulin and it's because of the negative perception people have of insulin. Afrezza is different enough to be able to put some of those concerns to rest, but right now it is grouped with all other insulins. The problem is how to put distance between Afrezza and RAA as the trial data, and hence label, is not sufficient different to allow the necessary claims to be made. A couple of interesting data points on type 2; a typical delay to start insulin seems to be around 2 years with 50% still not having started 5 years later, and about 5% of people never fill their first insulin prescription with a further 25% never refilling their prescription. The insulin manufacturers are all over this research because it is losing them market, they need to find out how to make people more willing to take insulin. One if the better studies I have seen on this topic ( Barriers to Insulin Initiation) gave the following reasons: Subjects failing to initiate prescribed insulin commonly reported misconceptions regarding insulin risk (35% believed that insulin causes blindness, renal failure, amputations, heart attacks, strokes, or early death), plans to instead work harder on behavioral goals, sense of personal failure, low self-efficacy, injection phobia, hypoglycemia concerns, negative impact on social life and job, inadequate health literacy, health care provider inadequately explaining risks/benefits, and limited insulin self-management training.
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Post by boca1girl on Mar 17, 2019 13:05:51 GMT -5
Funny about perception. Listen to all the warnings and potential side effects of those “NOT INSULIN” products. I hope someday we have a commercial that shows head to head comparisons of negative side effects between non-insulin products and Afrezza. And don’t bother with a come back that insulin can kill you. Afrezza isn’t your “father’s” insulin and has not killed anyone. There are a lot of studies out there showing why people resist starting insulin and it's because of the negative perception people have of insulin. Afrezza is different enough to be able to put some of those concerns to rest, but right now it is grouped with all other insulins. The problem is how to put distance between Afrezza and RAA as the trial data, and hence label, is not sufficient different to allow the necessary claims to be made. A couple of interesting data points on type 2; a typical delay to start insulin seems to be around 2 years with 50% still not having started 5 years later, and about 5% of people never fill their first insulin prescription with a further 25% never refilling their prescription. The insulin manufacturers are all over this research because it is losing them market, they need to find out how to make people more willing to take insulin. One if the better studies I have seen on this topic ( Barriers to Insulin Initiation) gave the following reasons: Subjects failing to initiate prescribed insulin commonly reported misconceptions regarding insulin risk (35% believed that insulin causes blindness, renal failure, amputations, heart attacks, strokes, or early death), plans to instead work harder on behavioral goals, sense of personal failure, low self-efficacy, injection phobia, hypoglycemia concerns, negative impact on social life and job, inadequate health literacy, health care provider inadequately explaining risks/benefits, and limited insulin self-management training.
Aged: I totally agree with you that people are resistant to start insulin treatement. I believe it is mostly from the thought of injections and the sense of failure. My 88 year old Mom describes my T2 cousin as a bad diabetic because she has progressed to basal insulin. She believes that my “prediabetic” brother is not that bad because he only takes two oral meds (but has not changed his eating habits or exercise level). With education and the awareness of Afrezza, I truly believe those perceptions can and will change. Otherwise I would have bailed on MNKD as an investment many years ago. |
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Post by rockstarrick on Mar 17, 2019 13:14:42 GMT -5
Funny about perception. Listen to all the warnings and potential side effects of those “NOT INSULIN” products. I hope someday we have a commercial that shows head to head comparisons of negative side effects between non-insulin products and Afrezza. And don’t bother with a come back that insulin can kill you. Afrezza isn’t your “father’s” insulin and has not killed anyone. There are a lot of studies out there showing why people resist starting insulin and it's because of the negative perception people have of insulin. Afrezza is different enough to be able to put some of those concerns to rest, but right now it is grouped with all other insulins. The problem is how to put distance between Afrezza and RAA as the trial data, and hence label, is not sufficient different to allow the necessary claims to be made. A couple of interesting data points on type 2; a typical delay to start insulin seems to be around 2 years with 50% still not having started 5 years later, and about 5% of people never fill their first insulin prescription with a further 25% never refilling their prescription. The insulin manufacturers are all over this research because it is losing them market, they need to find out how to make people more willing to take insulin. One if the better studies I have seen on this topic ( Barriers to Insulin Initiation) gave the following reasons: Subjects failing to initiate prescribed insulin commonly reported misconceptions regarding insulin risk (35% believed that insulin causes blindness, renal failure, amputations, heart attacks, strokes, or early death), plans to instead work harder on behavioral goals, sense of personal failure, low self-efficacy, injection phobia, hypoglycemia concerns, negative impact on social life and job, inadequate health literacy, health care provider inadequately explaining risks/benefits, and limited insulin self-management training.
And the answer to that problem, (separating Afrezza from other RAA’s), is common sense, and a little bit of FairPlay from those calling the shots, who lack this common sense. If the problem was just the opposite, (trying to get Afrezza in the same class as RAA’s), these idiots would be pulling from the other end to ensure that didn’t happen too. Afrezza is powder form Inhaled Human Insulin, absolutely, and completely different from other Mealtime options, and the only thing that RAA’s and Afrezza have in common, is they both lower blood glucose levels. This blatant intentional ignorance by those in charge of keeping people healthy is starting to really come to the surface,, 20 years ago I would’ve had my Father in Laws Endocrinologists outside in the parking lot in a rear naked choke. I can see why HCP’s are cautious when a new drug comes out, but when a person is struggling to self treat a chronic disease such as diabetes, and are willing and requesting to try something new, the HCP shouldn’t deny this, especially when so many PWD are gloating life changing results. Who in the hell do these people think they are ?? I’ll be heading to Iowa in May to get my Wife’s Father switched over to Afrezza, and get him his CGM that is already approved, something that we have been passively working on since 2015, but my patience is wearing thin. And I won’t take another no for an answer. If he really wants to try Afrezza, he’s getting a script, period. I just hope I don’t have to insult somebody’s intelligence to get it done. ✌🏻😎 |
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Post by mnholdem on Mar 17, 2019 16:40:10 GMT -5
...or have to administer a choke-hold attitude adjustment.  |
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Post by rockstarrick on Mar 17, 2019 17:21:39 GMT -5
...or have to administer a choke-hold attitude adjustment. Like I said, I understand the caution, but when a patient is asking for it, and his Son in Law is standing there with VDEX White paper, countless testimonials, pictures of official A1c’s, one in particular @ 4.8, and the Guy just sits there with the deer in the headlights look 👀 Hard to imagine being a Healthcare Provider being that complacent, and with an ego that big. He needs to seriously think about retirement, because eventually, somebody’s going to lose it with him !! I flew from Northwest Washington to the Gulf of Mexico, because my wife’s Father wanted me to go with him to his appointment, so I could share some information with this guy. You know, kind of like that education campaign that should’ve been done pre-launch. And now I will be flying to Iowa in May to finish the job. imagine being a T1d, and an investor, and having your endo tell you no ! Fighting words in my world all day long. 👊🏻😎 |
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Post by sportsrancho on Mar 17, 2019 18:36:40 GMT -5
You go Rick, I worked for a CEO for a long time who told me that, “they think they’re God!” And some patients are not strong enough to stand up for themselves, and to remember that “they work for you!”
Funny how they hand out pain drugs, Xanax, Valium..like candy, not to mention the other big ones. My girlfriend just happened to want some Xanax and her insurance paid for therapy-counseling so she went in there and got the drug. For free I might add. And these diabetics can’t even get on a life-saving drug! Makes me want to cry💔
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Post by rockstarrick on Mar 17, 2019 19:58:39 GMT -5
You go Rick, I worked for a CEO for a long time who told me that, “they think they’re God!” And some patients are not strong enough to stand up for themselves, and to remember that “they work for you!” Funny how they hand out pain drugs, Xanax, Valium..like candy, not to mention the other big ones. My girlfriend just happened to want some Xanax and her insurance paid for therapy-counseling so she went in there and got the drug. For free I might add. And these diabetics can’t even get on a life-saving drug! Makes me want to cry💔 The thing that really bothers me, is in 2015, when he initially started talking to his Endocrinologists about Afrezza, he was doing pretty good, but it was apparent to me, that he really didn’t know how to effectively manage his diabetes. Fast forward 3 1/2 years, and his health is now in the can !! So while I sit and watch PWD using Afrezza, and read their stories of success, and better overall health, I have to wonder how he would be now, if we would’ve kicked his Dr to the curb in 2015. If I was a HCP, and I watched one of my patients health decline this bad in 3 years, under my care, I would feel like a complete failure. Maybe it doesn’t come across in my writing, but I am extremely pissed at this clown 🤡 and I will always wonder what would’ve been different if he would’ve started on Afrezza in 2015. I’ll never know for sure, but I will always wonder. If it was me, representing me, I would’ve been in line right behind Sam Finta, but my wife’s Father doesn’t operate that way, and unfortunately, it has most likely cost him his health. |
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Post by sayhey24 on Mar 17, 2019 21:13:50 GMT -5
Funny about perception. Listen to all the warnings and potential side effects of those “NOT INSULIN” products. I hope someday we have a commercial that shows head to head comparisons of negative side effects between non-insulin products and Afrezza. And don’t bother with a come back that insulin can kill you. Afrezza isn’t your “father’s” insulin and has not killed anyone. There are a lot of studies out there showing why people resist starting insulin and it's because of the negative perception people have of insulin. Afrezza is different enough to be able to put some of those concerns to rest, but right now it is grouped with all other insulins. The problem is how to put distance between Afrezza and RAA as the trial data, and hence label, is not sufficient different to allow the necessary claims to be made. A couple of interesting data points on type 2; a typical delay to start insulin seems to be around 2 years with 50% still not having started 5 years later, and about 5% of people never fill their first insulin prescription with a further 25% never refilling their prescription. The insulin manufacturers are all over this research because it is losing them market, they need to find out how to make people more willing to take insulin. One if the better studies I have seen on this topic ( Barriers to Insulin Initiation) gave the following reasons: Subjects failing to initiate prescribed insulin commonly reported misconceptions regarding insulin risk (35% believed that insulin causes blindness, renal failure, amputations, heart attacks, strokes, or early death), plans to instead work harder on behavioral goals, sense of personal failure, low self-efficacy, injection phobia, hypoglycemia concerns, negative impact on social life and job, inadequate health literacy, health care provider inadequately explaining risks/benefits, and limited insulin self-management training.
Aged - "they need to find out how to make people more willing to take insulin"
Step 1 - their doctor needs to prescribe Step 2 - their doctor needs to prescribe Step 3 - .... more of the same
Their doctors are going to follow the standard of care. When does the SOC say to prescribe RAAs? The answer is the very last step after basal. When should meal time insulin be prescribed? That would be the very first step if we were correctly medically treating the fact the first thing the T2 loses is the robust insulin release at meal time.
Why is this not done? Two reasons; compliance; and hypoglycemia.
Compliance - No one likes needles and the injections and asking a T2 to take 3 shots a day is not going to happen because they do not get the immediate feedback like a T1 and what they can put of today they will. If they could simply inhale, thats a game changer.
Hypoglycemia - RAAs are dangerous and the risk has given rise to the entire oral market. If they had a product like afrezza where its really really hard getting a severe hypo when not using other diabetes meds. Thats a game changer. What makes afrezza so different? Aside from the in/out speed it works with the liver which gets back in sync and prevents the lows.
The insulin manufacturers can now stop doing research on how to make people more willing to take insulin. If they really want to make this happen they can get behind Dr. Kendall's efforts and make afrezza Step 1 in T2 care. I doubt they will. In fact I think they will do everything they can to stop him.
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Post by mannmade on Mar 17, 2019 22:05:07 GMT -5
Here’s an idea... Mnkd should license afrezza to Lilly, Novo and Sanofi and let them all sell inhaled insulin under their own brands. Then everyone benefits including pwd. GLTAL’s!
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Post by akemp3000 on Mar 17, 2019 22:49:38 GMT -5
Here’s an idea... Mnkd should license afrezza to Lilly, Novo and Sanofi and let them all sell inhaled insulin under their own brands. Then everyone benefits including pwd. GLTAL’s! Interesting thought. I'd rather crush them all. Death by a thousand puffs. |
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Post by agedhippie on Mar 18, 2019 8:03:50 GMT -5
There are a lot of studies out there showing why people resist starting insulin and it's because of the negative perception people have of insulin. Afrezza is different enough to be able to put some of those concerns to rest, but right now it is grouped with all other insulins. The problem is how to put distance between Afrezza and RAA as the trial data, and hence label, is not sufficient different to allow the necessary claims to be made. A couple of interesting data points on type 2; a typical delay to start insulin seems to be around 2 years with 50% still not having started 5 years later, and about 5% of people never fill their first insulin prescription with a further 25% never refilling their prescription. The insulin manufacturers are all over this research because it is losing them market, they need to find out how to make people more willing to take insulin. One if the better studies I have seen on this topic ( Barriers to Insulin Initiation) gave the following reasons: Subjects failing to initiate prescribed insulin commonly reported misconceptions regarding insulin risk (35% believed that insulin causes blindness, renal failure, amputations, heart attacks, strokes, or early death), plans to instead work harder on behavioral goals, sense of personal failure, low self-efficacy, injection phobia, hypoglycemia concerns, negative impact on social life and job, inadequate health literacy, health care provider inadequately explaining risks/benefits, and limited insulin self-management training.
Aged - "they need to find out how to make people more willing to take insulin"
Step 1 - their doctor needs to prescribe Step 2 - their doctor needs to prescribe Step 3 - .... more of the same
Their doctors are going to follow the standard of care. When does the SOC say to prescribe RAAs? The answer is the very last step after basal. When should meal time insulin be prescribed? That would be the very first step if we were correctly medically treating the fact the first thing the T2 loses is the robust insulin release at meal time.
Why is this not done? Two reasons; compliance; and hypoglycemia.
Compliance - No one likes needles and the injections and asking a T2 to take 3 shots a day is not going to happen because they do not get the immediate feedback like a T1 and what they can put of today they will. If they could simply inhale, thats a game changer.
Hypoglycemia - RAAs are dangerous and the risk has given rise to the entire oral market. If they had a product like afrezza where its really really hard getting a severe hypo when not using other diabetes meds. Thats a game changer. What makes afrezza so different? Aside from the in/out speed it works with the liver which gets back in sync and prevents the lows.
The insulin manufacturers can now stop doing research on how to make people more willing to take insulin. If they really want to make this happen they can get behind Dr. Kendall's efforts and make afrezza Step 1 in T2 care. I doubt they will. In fact I think they will do everything they can to stop him. The problem is that a mythology has grown up around insulin. Look at the study; the biggest group, 35% of the people, think that taking insulin will increase their chance of complications. Most of the other objections have nothing to do with needles or hypos, it's around what insulin itself implies about their lifestyle. That is what the insulin manufacturers are trying to change and is (almost, since Afrezza does address needles and hypos to an extent) equally valid whether the insulin is RAA or Afrezza. Some of this is also a side effect of the choice we have in the medical system. If you are in a developing country I suspect that the range of treatment options is a lot more limited so you are going to be on insulin quicker. In the US if you want to avoid insulin there is a whole cocktail of drugs that will let you put off the move to insulin. |
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