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Post by sportsrancho on Jul 14, 2019 0:24:28 GMT -5
What Charlie just wrote on ST.. see my post in the MNKD on StockTwits thread. This is huge, this is a major problem, the Endo’s would not up sweedee dad’s dosage either. He gave up because of that and insurance. It’s heartbreaking. I hate that this is happening. People feel so much better when they’re on Afrezza. It’s life-changing for kids because their parents makes so many trips to the ER because of lows! The Endo’s are scared of it. Unfamiliar and un-educated. Many times you don’t need to follow up dose if you take enough in the beginning.
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Post by sportsrancho on Jul 14, 2019 0:43:03 GMT -5
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Post by rtmd on Jul 14, 2019 7:05:14 GMT -5
The label says:
"Adjust the dosage of AFREZZA based on the individual's metabolic needs, blood glucose monitoring results and glycemic control goal.
Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness [see Warnings and Precautions (5.3) , and Use in Specific Populations (8.5, 8.6)].
Carefully monitor blood glucose control in patients requiring high doses of AFREZZA. If, in these patients, blood glucose control is not achieved with increased AFREZZA doses, consider use of subcutaneous mealtime insulin."
That seems to cover Charlie's and most others' situation. I don't see how the instructions could be improved upon.
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Post by sayhey24 on Jul 14, 2019 7:30:41 GMT -5
Yes, but you need to read the label. For the last five years we have been learning and relearning exactly what Al talked about after all the trials he did. I am not sure anything is new, not the dosing nothing. Maybe the sip of water and slowly inhaling to reduce coughing Al did not mention.
My question is, where is Dr. Kendall? Everyone seems to want to beat up on Mike, but Dave told us this was going to be the easiest job he ever had.
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Post by rtmd on Jul 14, 2019 7:50:12 GMT -5
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Post by sportsrancho on Jul 14, 2019 8:06:19 GMT -5
Yes, but you need to read the label. For the last five years we have been learning and relearning exactly what Al talked about after all the trials he did. I am not sure anything is new, not the dosing nothing. Maybe the sip of water and slowly inhaling to reduce coughing Al did not mention. My question is, where is Dr. Kendall? Everyone seems to want to beat up on Mike, but Dave told us this was going to be the easiest job he ever had. Yes agree! I think Al even mentioned the sip of water. The girl in the video is awesome but she’s not taking enough Afrezza either.
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Post by sportsrancho on Jul 14, 2019 14:40:26 GMT -5
Charles Lacey
$MNKD sales reps are the first line of defense. they need to be mores than salespeople. they need to be teachers of afrezza also. if they wont do it than pay them more. we are loosing the battle for evermore with afrezza. nurse practioners need to be hired as sales people and also teachers of the use of afrezza. otherwise we loose the battle. Look afrezza is a very tricky insulin and a new user will be lost without being taught how to use it. for instance a puff before meals and a puff after. you can also use afrezza during the day without meals to regulate your sugars. lets say your sugar goes up for whatever reason , you can take a puff and bring it right down. I’m neither pro or con on VDEX but i will say this they could play a huge part in teaching patients how to use afrezza correctly.
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Post by lifebreath on Jul 14, 2019 15:16:41 GMT -5
Charles Lacey $MNKD sales reps are the first line of defense. they need to be mores than salespeople. they need to be teachers of afrezza also. if they wont do it than pay them more. we are loosing the battle for evermore with afrezza. nurse practioners need to be hired as sales people and also teachers of the use of afrezza. otherwise we loose the battle. Look afrezza is a very tricky insulin and a new user will be lost without being taught how to use it. for instance a puff before meals and a puff after. you can also use afrezza during the day without meals to regulate your sugars. lets say your sugar goes up for whatever reason , you can take a puff and bring it right down. I’m neither pro or con on VDEX but i will say this they could play a huge part in teaching patients how to use afrezza correctly. What many people are continuing to be remiss about mentioning is the importance of technique with inhalation. Something the vdex clinic can teach upfront instead of a patient trying to figure out through trial and error.
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Dosing
Jul 14, 2019 15:46:35 GMT -5
Post by lennymnkd on Jul 14, 2019 15:46:35 GMT -5
Can antibiotics be administered with Technosphere. ? Pc in NYT’s that infections are becoming more resistant to medications even requiring intravenous.... antibiotics big market...
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Post by stevil on Jul 14, 2019 16:06:29 GMT -5
Can antibiotics be administered with Technosphere. ? Pc in NYT’s that infections are becoming more resistant to medications even requiring intravenous.... antibiotics bid market... This could be a potentially huge market as patients are sometimes required to stay in the hospital for several extra days even after they are stable for continued IV therapy. Sometimes they're sent home with PICC lines for the treatments that require multiple weeks of IV therapy. But they come with an increased risk of infections themselves. So there is great value to inhaled antibiotics. If I were Mannkind, I'd think about the most common ones, like Vancomycin (although that usually requires a trough to ensure proper blood levels), Zosyn and others.
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Post by peppy on Jul 14, 2019 16:12:22 GMT -5
Can antibiotics be administered with Technosphere. ? Pc in NYT’s that infections are becoming more resistant to medications even requiring intravenous.... antibiotics big market... yes vancomycin is in the pipeline.
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Dosing
Jul 14, 2019 16:13:54 GMT -5
Post by stevil on Jul 14, 2019 16:13:54 GMT -5
antibiotics these days have a short life span. They need to get going while resistance is low.
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Post by peppy on Jul 14, 2019 18:19:44 GMT -5
Can antibiotics be administered with Technosphere. ? Pc in NYT’s that infections are becoming more resistant to medications even requiring intravenous.... antibiotics bid market... This could be a potentially huge market as patients are sometimes required to stay in the hospital for several extra days even after they are stable for continued IV therapy. Sometimes they're sent home with PICC lines for the treatments that require multiple weeks of IV therapy. But they come with an increased risk of infections themselves. So there is great value to inhaled antibiotics. If I were Mannkind, I'd think about the most common ones, like Vancomycin (although that usually requires a trough to ensure proper blood levels), Zosyn and others. Candida auris. www.cdc.gov/fungal/candida-auris/index.htmldeath rate is @ 50%. hard to identify because it IS candida. however it is not albicans. Vancomycin
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Dosing
Jul 14, 2019 18:36:08 GMT -5
Post by rtmd on Jul 14, 2019 18:36:08 GMT -5
Can antibiotics be administered with Technosphere. ? Pc in NYT’s that infections are becoming more resistant to medications even requiring intravenous.... antibiotics bid market... This could be a potentially huge market as patients are sometimes required to stay in the hospital for several extra days even after they are stable for continued IV therapy. Sometimes they're sent home with PICC lines for the treatments that require multiple weeks of IV therapy. But they come with an increased risk of infections themselves. So there is great value to inhaled antibiotics. If I were Mannkind, I'd think about the most common ones, like Vancomycin (although that usually requires a trough to ensure proper blood levels), Zosyn and others. Inhaled antibiotics have been used to treat infections since the 1940s. These are usually lung infections, however. Some antibiotics, like the aminoglycosides, basically don't cross into the systemic circulation. Others, like vancomycin, have limited ability to cross the alveolar-capillary membrane as well, and would likely require very high doses to treat systemic ailments. Most important, though, is price. Nebulization effectively delivers antibiotics to the lung. Could technosphere/antibiotic compete with nebulized plain antibiotic on price?
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Dosing
Jul 14, 2019 18:44:43 GMT -5
Post by rtmd on Jul 14, 2019 18:44:43 GMT -5
This could be a potentially huge market as patients are sometimes required to stay in the hospital for several extra days even after they are stable for continued IV therapy. Sometimes they're sent home with PICC lines for the treatments that require multiple weeks of IV therapy. But they come with an increased risk of infections themselves. So there is great value to inhaled antibiotics. If I were Mannkind, I'd think about the most common ones, like Vancomycin (although that usually requires a trough to ensure proper blood levels), Zosyn and others. Candida auris. www.cdc.gov/fungal/candida-auris/index.htmldeath rate is @ 50%. hard to identify because it IS candida. however it is not albicans. Vancomycin I'm pretty sure vancomycin wouldn't be considered against candida auris: www.cdc.gov/fungal/candida-auris/c-auris-treatment.html If anything treatment with vancomycin would predispose to infection by candida auris.
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