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Post by novafett on Aug 2, 2019 11:13:45 GMT -5
What the heck is going on? Stupid work browser won't open any links for some reason. Checked the MNKD Yahoo finance page but no news. Where you all hearing about new ad campaign? Can you use your phone? I was able to see it in the embedded link you put up in the Twitter topic. Thanks! |
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Post by johnhinde on Aug 2, 2019 11:20:16 GMT -5
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Post by mytakeonit on Aug 2, 2019 12:48:14 GMT -5
Hilarity? ... and wonderment? was what I felt when I viewed the video ad. The hilarity part was watching people listen to this guy say to wait before eating and have ice cream dripping down their hands. Wonderment was ... where the heck did they find idiot people like them?!!! In Hawaii, even a kid would have told the guy "Hell with you!" Then eat the whole ice cream in one bite.
Also why the ad was created so long? Because we could. We weren't limited to a multi Kazillion dollar ad lasting for under a minute.
But, that's mytakeonit
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Post by mnholdem on Aug 2, 2019 13:02:12 GMT -5
I get your tongue-in-cheek humor, but I suspect that PWDs in Hawaii are no different than any other state, although you could check to see if Hawaii has more admissions to hospitals. That might support your statement.
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Post by agedhippie on Aug 2, 2019 13:29:21 GMT -5
Absolutely nobody is against options and another tool in the toolbox is always welcome. Saying you can't have ice cream because you haven't pre-bolused is just silly though, and no needles is largely irrelevant. If no needles resonated strongly then at some point in the last four and a half years sales would have taken off - that approach is one thoroughly beaten horse. If I was designing an advert to appeal to diabetics I would ignore no needles entirely and focus on speed to achieve a correction, and on predictability. I don't care if I inhale, drink, or inject insulin. Likewise if I always take insulin at the start of eating then why does not needing to pre-bolus matter? What I care about is in practical terms how this particular insulin makes my life immediately better. Benefits and not features. With respect to the bolded sentence I assume you're referring to a non-standard practice of a PWD using needle/pen + RAA.
The dosing instructions for Afrezza when it launched in early 2015 was developed according to FDA approval and guidelines. I assumed the reference to the 15 minute interval of pre-bolus before meal was a reference to the instructions for RAA insulins.
Based on what I've read and PWDs I've known, I've assumed the big lifestyle advantage of inhaling Afrezza with the meal was freedom. Freedom to choose the dose when the meal arrives, and adjust, if needed, the dose to the meal instead of the other way around. And the freedom to dose with less of a stigma at the table instead of in the bathroom (if at a restaurant). And the freedom of stacking without as much concern about a long tail and having to snack to deal with a hypoglycemic event.
These are all the perceptions of a non-PWD, so I may be wrong or put too much emphasis on these benefits.
That bolded sentence is correct practice. If you look at the RAA labels contrary to what you are assuming all of them say bolusing at the start of the meal is fine (Humalog actually says bolusing at the end of the meal is fine too). The big selling point of RAA when it was released was the removal of the need to pre-bolus. The endos were all going around saying that you could get on with your life and just dose when and if you eat (there was a big issue with Regular insulin around pre-bolusing and then not eating in time). People really go and bolus in the bathroom? Who does that?  Ok, I am sure someone does but I bolus at the table as does everyone else I know. With a pump it's just a button push, with a pen it's trivial to do it discretely. Inhaling insulin might be more tricky to do discretely! Nobody has ever screamed and run from the room, but I tend to be discrete because otherwise the conversation often turns to diabetes and it always seems someone has a pet harebrained theory which they seem to think you cannot live without knowing. Stacking is one of the frustrating things that for some reason people here are hung up on. It's a non-event. You stack all the time. If you take Tresiba you are stacking right there! That tail is what means that I can only dose once for a meal whereas I would have to dose twice if I was using Afrezza (talk about freedom). Now Afrezza is a good insulin, but it's not the holy grail (that's reactive insulin) and like everything it has it's pros and cons. I get beaten up for talking about the cons (everyone else is talking about the pros so there is not much I can contribute there). |
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Post by sweedee79 on Aug 2, 2019 14:01:04 GMT -5
RAA is a manufactured synthetic insulin that doesn't even come close to what a healthy pancreas does.. Afrezza is a much closer match and more natural and IMO, a healthier choice..
I'm not diabetic.. but I just don't get why anyone would defend RAA or choose to stay on it based on my experience anyway..
I've talked to a few PWD who were very interested in Afrezza... So I do believe given the right marketing and doctors and insurance on board many would make the switch..
Retention has been a huge problem, so it isn't that people don't want to try it necessarily... they have to have the support behind them.
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Post by longliner on Aug 2, 2019 14:17:10 GMT -5
With respect to the bolded sentence I assume you're referring to a non-standard practice of a PWD using needle/pen + RAA.
The dosing instructions for Afrezza when it launched in early 2015 was developed according to FDA approval and guidelines. I assumed the reference to the 15 minute interval of pre-bolus before meal was a reference to the instructions for RAA insulins.
Based on what I've read and PWDs I've known, I've assumed the big lifestyle advantage of inhaling Afrezza with the meal was freedom. Freedom to choose the dose when the meal arrives, and adjust, if needed, the dose to the meal instead of the other way around. And the freedom to dose with less of a stigma at the table instead of in the bathroom (if at a restaurant). And the freedom of stacking without as much concern about a long tail and having to snack to deal with a hypoglycemic event.
These are all the perceptions of a non-PWD, so I may be wrong or put too much emphasis on these benefits.
That bolded sentence is correct practice. If you look at the RAA labels contrary to what you are assuming all of them say bolusing at the start of the meal is fine (Humalog actually says bolusing at the end of the meal is fine too). The big selling point of RAA when it was released was the removal of the need to pre-bolus. The endos were all going around saying that you could get on with your life and just dose when and if you eat (there was a big issue with Regular insulin around pre-bolusing and then not eating in time). People really go and bolus in the bathroom? Who does that? Ok, I am sure someone does but I bolus at the table as does everyone else I know. With a pump it's just a button push, with a pen it's trivial to do it discretely. Inhaling insulin might be more tricky to do discretely! Nobody has ever screamed and run from the room, but I tend to be discrete because otherwise the conversation often turns to diabetes and it always seems someone has a pet harebrained theory which they seem to think you cannot live without knowing. Stacking is one of the frustrating things that for some reason people here are hung up on. It's a non-event. You stack all the time. If you take Tresiba you are stacking right there! That tail is what means that I can only dose once for a meal whereas I would have to dose twice if I was using Afrezza (talk about freedom). Now Afrezza is a good insulin, but it's not the holy grail (that's reactive insulin) and like everything it has it's pros and cons. I get beaten up for talking about the cons (everyone else is talking about the pros so there is not much I can contribute there). Why day in and day out do you try to discredit this technology? Admittedly, you don't comment on any of the medications you claim to use, yet you have endless time to commit to comment negatively on this one product.................  There really is only one explanation. |
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Post by agedhippie on Aug 2, 2019 15:43:35 GMT -5
Why day in and day out do you try to discredit this technology? Admittedly, you don't comment on any of the medications you claim to use, yet you have endless time to commit to comment negatively on this one product................. There really is only one explanation. Ok, I'll bite. You believe that explanation is? |
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Post by longliner on Aug 2, 2019 15:44:49 GMT -5
Why day in and day out do you try to discredit this technology? Admittedly, you don't comment on any of the medications you claim to use, yet you have endless time to commit to comment negatively on this one product................. There really is only one explanation. Ok, I'll bite. You believe that explanation is? You would like this technology to fail. |
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Post by agedhippie on Aug 2, 2019 16:17:10 GMT -5
Ok, I'll bite. You believe that explanation is? You would like this technology to fail. Absolutely not. I want diabetics to have as many options as possible. I think until there is hard trial data this is going to be a long slow haul and people probably ought to get comfortable with that rather than expect a rapid turnaround. One pattern is that the licensing work fills that gap. |
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Post by lennymnkd on Aug 2, 2019 16:41:22 GMT -5
RAA is a manufactured synthetic insulin that doesn't even come close to what a healthy pancreas does.. Afrezza is a much closer match and more natural and IMO, a healthier choice.. I'm not diabetic.. but I just don't get why anyone would defend RAA or choose to stay on it based on my experience anyway.. I've talked to a few PWD who were very interested in Afrezza... So I do believe given the right marketing and doctors and insurance on board many would make the switch.. Retention has been a huge problem, so it isn't that people don't want to try it necessarily... they have to have the support behind them. Retention =VDEX |
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Post by mnholdem on Aug 2, 2019 17:32:58 GMT -5
RAA is a manufactured synthetic insulin that doesn't even come close to what a healthy pancreas does.. Afrezza is a much closer match and more natural and IMO, a healthier choice.. I'm not diabetic.. but I just don't get why anyone would defend RAA or choose to stay on it based on my experience anyway.. I've talked to a few PWD who were very interested in Afrezza... So I do believe given the right marketing and doctors and insurance on board many would make the switch.. Retention has been a huge problem, so it isn't that people don't want to try it necessarily... they have to have the support behind them. We haven’t heard from Spiro for some time but within a year of starting Afrezza his doctor has taken him off most of his other meds (ie liver improved) so I’m thinking there is some credence to what you say. |
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Post by mytakeonit on Aug 3, 2019 1:58:37 GMT -5
I get your tongue-in-cheek humor, but I suspect that PWDs in Hawaii are no different than any other state, although you could check to see if Hawaii has more admissions to hospitals. That might support your statement. mnholdem ... I get it that you don't like me. But, what is it that you didn't like in my post? If you don't know, I am diabetic, but I have been diagnosed as pre diabetic since my out go physical from the Air Force ... where I was considered a disabled veteran and give a 30% disabled veteran status. My numbers has not changed and I do minimal medical work if they ask me to do it. So, respond on the board or you can direct message me. BTW, I consider myself to be a major stockholder in MNKD ... probably more than you are. I loved the video ... and I love that the fact that now we are getting OUR views out there. I can't wait for the CC after the quarterly. I believe that we are headed to major acceptance and valuation. |
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Post by mnholdem on Aug 3, 2019 7:13:02 GMT -5
Nothing personal but when you describe people in the ads as idiots I assumed you were joking. The entire point of the ad was to educate not onkybthat PWD cannot just spontaneous eat if they must first inject their RAA insulin but that there exists a different insulin that can make a big difference. Diabetes is serious and can be dangerous and your suggestion that they should say “to hell with you” and go ahead and eat the ice cream just touched a nerve, I guess. Apologies.
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Post by prcgorman2 on Aug 3, 2019 11:29:28 GMT -5
I thought it was a funny comment on Hawaiians having a down-to-earth attitude about things, and if you just handed one “free ice cream” they’re not going to be concerned with what else you might have to say before enjoying the confection. I’ve visited Hawaii several times and have a friend/associate from Oahu and although I should perhaps not generalize, I can’t help thinking mytakeonit’s characterization was accurate and amusing. And neither of you should be upset with the other. You’re both likeable.
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Ok, I am sure someone does but I bolus at the table as does everyone else I know. With a pump it's just a button push, with a pen it's trivial to do it discretely. Inhaling insulin might be more tricky to do discretely! Nobody has ever screamed and run from the room, but I tend to be discrete because otherwise the conversation often turns to diabetes and it always seems someone has a pet harebrained theory which they seem to think you cannot live without knowing.
There really is only one explanation.