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Post by agedhippie on Aug 3, 2019 11:46:51 GMT -5
... The entire point of the ad was to educate not only that PWD cannot just spontaneous eat if they must first inject their RAA insulin but that there exists a different insulin that can make a big difference.... The ad is actually wrong in that respect. Why RAA was such a big deal was because for the first time you could just spontaneous eat. That message has been repeated endlessly by the medical world for the last twenty years. In consequence when people say you have to prebolus for ice cream this small voice at the back of your mind says, "That's wrong". Yes, Afrezza will deal with it better, but RAA will do a perfectly reasonable job (it helps that ice cream is high fat and so digests slowly). For the most part though I suspect the your average Type 1 would listen to the nice man while eating the ice cream (it's only polite  and then bolus. |
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Post by sportsrancho on Aug 3, 2019 11:56:54 GMT -5
Seems we have more than a new marketing campaign we may have a co-marketing campaign...
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Post by peppy on Aug 3, 2019 12:05:15 GMT -5
... The entire point of the ad was to educate not only that PWD cannot just spontaneous eat if they must first inject their RAA insulin but that there exists a different insulin that can make a big difference.... The ad is actually wrong in that respect. Why RAA was such a big deal was because for the first time you could just spontaneous eat. That message has been repeated endlessly by the medical world for the last twenty years. In consequence when people say you have to prebolus for ice cream this small voice at the back of your mind says, "That's wrong". Yes, Afrezza will deal with it better, but RAA will do a perfectly reasonable job (it helps that ice cream is high fat and so digests slowly). For the most part though I suspect the your average Type 1 would listen to the nice man while eating the ice cream (it's only polite and then bolus. saids: The vast majority and one of the big unmet needs in any individual with type 1 diabetes — no matter what age
— is insulin that has a rapid onset and a rapid offset because this coupled with the post-meal spikes also helps tremendously with a reduction in delayed hypoglycemia.The current insulin — even the faster acting analogs — they take too long to get into the system, they peak late, and they also hang around for a long time. So, when someone with type 1 diabetes, even in the pediatric age group is no exception, unexpected highs unexpected lows and it's very frustrating to use our current injectable fast acting influence because they just don't work fast enough and they hang around for just too long. www.mdmag.com/medical-news/steven-edelman-md-current-state-of-postprandial-glucose-controlagedhippie , I get it, the 3:30 ice cream may help with your tail.  |
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Post by mytakeonit on Aug 3, 2019 12:33:21 GMT -5
mnholdem - Thanks for the apology/explanation and I do accept it. In Hawaii we don't express ourselves as much as mainland USA visitors and maybe we do come on as being harsh. Islanders understand this "one word = ten words equation" ... so we laugh it up and be done. I also have relatives that live all over the USA and when they visit ... they also may ask for me/we to elaborate. They get it and laugh. Sometimes they leave using some of these phrases and wonder if their neighbors back home will understand them. "Gotta live it to understand it" BTW, if you ever visit Hawaii ... you probably will hear people say "No Act" ... "Don't be an idiot" ... etc. We all laugh without any problems. Thanks for the reply.
And thanks prcgorman2 for being a referee and interpreter.
But, that's mytakeonit
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Post by agedhippie on Aug 3, 2019 12:48:27 GMT -5
The ad is actually wrong in that respect. Why RAA was such a big deal was because for the first time you could just spontaneous eat. That message has been repeated endlessly by the medical world for the last twenty years. In consequence when people say you have to prebolus for ice cream this small voice at the back of your mind says, "That's wrong". Yes, Afrezza will deal with it better, but RAA will do a perfectly reasonable job (it helps that ice cream is high fat and so digests slowly). For the most part though I suspect the your average Type 1 would listen to the nice man while eating the ice cream (it's only polite and then bolus. saids: The vast majority and one of the big unmet needs in any individual with type 1 diabetes — no matter what age
— is insulin that has a rapid onset and a rapid offset because this coupled with the post-meal spikes also helps tremendously with a reduction in delayed hypoglycemia.The current insulin — even the faster acting analogs — they take too long to get into the system, they peak late, and they also hang around for a long time. So, when someone with type 1 diabetes, even in the pediatric age group is no exception, unexpected highs unexpected lows and it's very frustrating to use our current injectable fast acting influence because they just don't work fast enough and they hang around for just too long. www.mdmag.com/medical-news/steven-edelman-md-current-state-of-postprandial-glucose-controlagedhippie , I get it, the 3:30 ice cream may help with your tail. It helps my self-justification for the ice cream. I am forced to eat it (now where is that hand to brow emote?).  |
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Post by longliner on Aug 3, 2019 22:48:19 GMT -5
Why day in and day out do you try to discredit this technology? Admittedly, you don't comment on any of the medications you claim to use, yet you have endless time to commit to comment negatively on this one product.................  There really is only one explanation. Ok, I'll bite. You believe that explanation is? You tell me? The moderators don't like my story.😏 This ad campaign is exactly what we need to demonstrate speed of action. I understand the need for large scale studies, and I'm sure you realize the cash constraints currently on the Company. |
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Post by agedhippie on Aug 4, 2019 8:54:51 GMT -5
Ok, I'll bite. You believe that explanation is? You tell me? The moderators don't like my story.😏 This ad campaign is exactly what we need to demonstrate speed of action. I understand the need for large scale studies, and I'm sure you realize the cash constraints currently on the Company. Actually you already told me - you think I want the technology to fail. That's wrong. I want diabetics to have every possible option. The speed of action sounds like you can take insulin when you start to eat. That is exactly what every diabetic has been told by their endo about RAA for the last 20 years. You are told you can spontaneously eat if you take RAA and this is widely believed. So saying that inhaled insulin does the same thing is not compelling. The company can raise cash for a trial but I would like the share price to be further from the $1 mark before it does that. What is happening right now is that the company keeps doing raises for anything but a trial. This is dumb because until the medical world changes it's view and starts to push Afrezza this is going to be slow going. You can pay now, or you can defer and burn the money anyway as operating losses. There is not a cheap solution to getting out of this corner so bite the bullet. |
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Post by sweedee79 on Aug 4, 2019 9:24:09 GMT -5
You tell me? The moderators don't like my story.😏 This ad campaign is exactly what we need to demonstrate speed of action. I understand the need for large scale studies, and I'm sure you realize the cash constraints currently on the Company. Actually you already told me - you think I want the technology to fail. That's wrong. I want diabetics to have every possible option. The speed of action sounds like you can take insulin when you start to eat. That is exactly what every diabetic has been told by their endo about RAA for the last 20 years. You are told you can spontaneously eat if you take RAA and this is widely believed. So saying that inhaled insulin does the same thing is not compelling. The company can raise cash for a trial but I would like the share price to be further from the $1 mark before it does that. What is happening right now is that the company keeps doing raises for anything but a trial. This is dumb because until the medical world changes it's view and starts to push Afrezza this is going to be slow going. You can pay now, or you can defer and burn the money anyway as operating losses. There is not a cheap solution to getting out of this corner so bite the bullet.ou Aged.. respectfully, I find your constant rhetoric against Afrezza somewhat suspect.. and for some reason it gets under my skin.. always has.. Yes some of what you say has some merit.. however you seem a little bit to eager to jump on the bandwagon about things.. Regarding RAA.. my dad is directed to take his Novolog 30 minutes prior to eating.. and I'm pretty sure this is quite standard practice.. OK.. defend away.. I'm sure you will have many explanations and excuses.. none of which will satisfy me... But knock yourself out.. |
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Post by agedhippie on Aug 4, 2019 12:51:13 GMT -5
Aged.. respectfully, I find your constant rhetoric against Afrezza somewhat suspect.. and for some reason it gets under my skin.. always has.. Yes some of what you say has some merit.. however you seem a little bit to eager to jump on the bandwagon about things.. Regarding RAA.. my dad is directed to take his Novolog 30 minutes prior to eating.. and I'm pretty sure this is quite standard practice.. OK.. defend away.. I'm sure you will have many explanations and excuses.. none of which will satisfy me... But knock yourself out.. The answer may not satisfy you, but it may help others. Routinely bolusing 30 minutes before eating with RAA is, to put it mildly, odd. The practice is completely unsupported by guidance ("it should be injected immediately (within 5-10 minutes) before a meal"). While the guidance your dad got sounds like a carry over from Regular insulin which was to dose 30 minutes before a meal ("... should be followed by a meal within approximately 30 minutes of administration.") I do not know why your dad's doctor told him to bolus 30 minutes before a meal. If I was to guess I would wonder if they ever updated their guidance from Regular, but equally it may be that they had some particular reason for wanting your dad to bolus that far in advance. It is certainly not normal and some distance outside the way Novolog is meant to be used. I would definitely have challenged this if I had been told to do this as I would have expected it to cause problems. Anyone who is told to always bolus 30 minutes before eating when using RAA should very definitely drill down into the detail of why because it is not normal and would, I expect, generally not go well. The official guidance is clear though and it does not advise bolusing 30 minutes before a meal with RAA. |
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Post by prcgorman2 on Aug 4, 2019 12:59:21 GMT -5
Ooh, a debate! I love those (when they’re good). agedhippie is a well-qualified contestant so his response should be good.
Now that we’ve seen (all of?) the content of the campaign, I am curious about the logistics. A vinyl billboard ad will cost between $300 and $500 for a 14’x48’ billboard and between $250 and $14,000 per month depending upon location and demographics. There are also ad development agency costs but those are minor. So, how many billboards, in what locations, with a monthly run-rate of $X and for what duration, would be nice to know (or have hints of).
Back to the topic of debating marketing versus superiority trial, what are the costs of a superiority trial (might need to be a new thread)? How long do they take? What are the expected benefits of a superiority trial? Does the FDA have to weigh in on the procedures followed? How often do superiority trials fail to provide hoped for results? Since we’re talking about a superiority trial in the context of it’s value for marketing, is a single trial sufficient, or do their need to be many trials? (Arming Sweedee for the marketing debate with agedhippie.). :-)
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Post by longliner on Aug 4, 2019 18:27:05 GMT -5
... The entire point of the ad was to educate not only that PWD cannot just spontaneous eat if they must first inject their RAA insulin but that there exists a different insulin that can make a big difference.... The ad is actually wrong in that respect. Why RAA was such a big deal was because for the first time you could just spontaneous eat. That message has been repeated endlessly by the medical world for the last twenty years. In consequence when people say you have to prebolus for ice cream this small voice at the back of your mind says, "That's wrong". Yes, Afrezza will deal with it better, but RAA will do a perfectly reasonable job (it helps that ice cream is high fat and so digests slowly). For the most part though I suspect the your average Type 1 would listen to the nice man while eating the ice cream (it's only polite and then bolus. So the ad is wrong and you are correct.......how to even respond? 😏 |
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Post by ktim on Aug 5, 2019 14:40:51 GMT -5
The ad is actually wrong in that respect. Why RAA was such a big deal was because for the first time you could just spontaneous eat. That message has been repeated endlessly by the medical world for the last twenty years. In consequence when people say you have to prebolus for ice cream this small voice at the back of your mind says, "That's wrong". Yes, Afrezza will deal with it better, but RAA will do a perfectly reasonable job (it helps that ice cream is high fat and so digests slowly). For the most part though I suspect the your average Type 1 would listen to the nice man while eating the ice cream (it's only polite and then bolus. So the ad is wrong and you are correct.......how to even respond? 😏 Perhaps the best response would be to look up the prescribing literature for Humalog and Novolog to see which is correct. It took me 20 seconds to do so. Novolog says within 5-10 min prior to meal and Humalog says within 15 min prior to meal or immediately after meal. Once one has the facts then they can refute if there is something to refute or avoid making unfounded accusations. [edit to add links for those wanting to shave 10 seconds off looking it up] www.novo-pi.com/novolog.pdfwww.accessdata.fda.gov/drugsatfda_docs/label/2013/020563s115lbl.pdf |
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Post by akemp3000 on Aug 5, 2019 15:21:52 GMT -5
Interesting to hear arguments regarding RAA instructions that are not working for the diabetic community. It's well known that the current standards of care are insufficient and are not working at getting most diabetics to an acceptable A1c or time-in-range. Fortunately, Afrezza can easily accomplish this once diabetics learn how to use Afrezza properly. CGMs, One Drop and Bluhale are going to play a major role in proving Afrezza's superiority with or without trials but hey, argue away  |
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Post by ktim on Aug 5, 2019 15:48:22 GMT -5
Interesting to hear arguments regarding RAA instructions that are not working for the diabetic community. It's well known that the current standards of care are insufficient and are not working at getting most diabetics to an acceptable A1c or time-in-range. Fortunately, Afrezza can easily accomplish this once diabetics learn how to use Afrezza properly. CGMs, One Drop and Bluhale are going to play a major role in proving Afrezza's superiority with or without trials but hey, argue away Fully agree on CGMs. I'd place that head and shoulders above the other two. Not really even sure how you think Bluhale would contribute to proving superiority. The current version doesn't really even seem compelling for patients to use (as logging device), in my opinion. If you've got a CGM and app, you've likely got your phone out to check things before bolusing anyway and hitting a button or two to log a dose of Afrezza seems simple enough that I would prefer doing that vs adding the bulk of the BluHale to what I'm carrying around (obviously there is some personal opinion involved there). I'll be interested to see whether patients really use Bluhale as a logging device vs as an inhalation training tool when first initiating Afrezza. There could be more desire to gadgetify one's life than I'd imagine. I never really saw the point of having pill bottle caps that log opening other than in limited cases where a third party is needing to monitor, but perhaps some people do like that. |
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Post by sportsrancho on Aug 8, 2019 22:33:33 GMT -5
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and then bolus.
There really is only one explanation.
