Vertex’s next act: a billion-dollar bet on a cure for type 1

[lakers]

Vertex’s next act: a billion-dollar bet on a cure for type 1 diabetes
www.statnews.com/2019/09/03/vertexs-next-act-a-billion-dollar-bet-on-a-cure-for-type-1-diabetes/

Also, Their CF oral is pending approval.

[MnkdWASmyRtrmntPlan]

Interesting find, Lakers.

[uvula]

I wonder why they put the stem cells in the liver instead of the pancreas. Maybe they can be anywhere in the body.

[shawnonafrezza]

Liver has lots of blood (the current islet transplants that go to liver still see a good ~50% die off) and is easy to get to, just inject through the portal vein. Fun fact, your liver has some 15% of your total blood volume! Fun fact 2, as far as total volume goes that isn't even #1!

[pengiep]

Would I be correct in that the pancreas is harder to access than the liver and much easier to damage. And as pointed out by others, the liver is highly vascularized and thus can support the ectopic location of these beta cells.