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Post by mango on Feb 25, 2020 11:11:10 GMT -5
Preliminary Technosphere Sumatriptan PK results show an ultra rapid profile, which mimics intra-arterial administration. These preliminary results are significantly better compared to current SoC therapies.  |
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Post by mango on Feb 25, 2020 11:17:35 GMT -5
Very excited to see where this goes. Any migraine sufferers on this board? What are your thoughts and would you like to try inhaled SumaT by MannKind?
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Post by rfogel on Feb 25, 2020 11:56:39 GMT -5
How do you get a rat to use an inhaler?
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Post by mango on Feb 25, 2020 12:03:28 GMT -5
How do you get a rat to use an inhaler? They use an inhaled delivery system designed for rats. |
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Post by mnholdem on Feb 25, 2020 16:00:06 GMT -5
Mike said they’ll table this unless they get a partner. I’d take it through Phase 1-2 trials to entice partners. An ultra-fasting migraine drug would address an unmet need.
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Post by mnholdem on Feb 25, 2020 16:04:15 GMT -5
Much like UT is replacing Tyvaso with Tyvaso (TS) I’d approach GSK with a deal for Imitrex(TS). Their #1 migraine drug is at its patent cliff.
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Post by brotherm1 on Feb 25, 2020 16:43:40 GMT -5
It appears according to this article that there is room for migraine inhalables. “ Inhaled therapies may be a viable alternative for many patients with migraine who are unable to find relief on other formulations. Unfortunately, their development is largely stalled. In a 2018 editorial, Franco Granella7 described the current frustration with the obstacles to introducing promising inhaled therapies to patients who need them. “[C]linical trials have shown brilliant results in terms of efficacy, rapidity of action and safety. In spite of these potential advantages, inhaled drugs have accounted so far for a tiny part of the market,” he concluded.” www.neurologyadvisor.com/advisor-channels/headache-migraine-advisor/inhaled-therapies-in-migraine-and-patient-satisfaction/ |
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Post by mango on Feb 25, 2020 16:46:55 GMT -5
Mike said they’ll table this unless they get a partner. I’d take it through Phase 1-2 trials to entice partners. An ultra-fasting migraine drug would address an unmet need. Did he say they would be taking it through Phase 1 or only preclinical studies? |
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Post by ktim on Feb 25, 2020 17:14:45 GMT -5
How do you get a rat to use an inhaler? I think there were lots of rats used in testing Afrezza, so they probably just have those rats show the new ones  Sorry How cute would that be for an ad... a rat holding dreamboat with both paws as he takes a puff. Though with the narrowing of focus recently announced MNKD doesn't seem to be going after inhaled veterinary drugs. |
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Post by rfogel on Feb 25, 2020 17:41:57 GMT -5
Currently available triptans include sumatriptan, zolmitriptan, naratriptan, rizatriptan, almotriptan, eletriptan, and frovatriptan. Is it really worth spending the money needed to wade into that herd and risk getting trampled?
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Post by brentie on Feb 25, 2020 19:12:27 GMT -5
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Post by peppy on Feb 25, 2020 19:20:12 GMT -5
I am changing my profile picture.  |
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Post by robbmo on Feb 25, 2020 19:23:19 GMT -5
Mike said they’ll table this unless they get a partner. I’d take it through Phase 1-2 trials to entice partners. An ultra-fasting migraine drug would address an unmet need. Did he say they would be taking it through Phase 1 or only preclinical studies? Through Phase 1. |
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Post by mango on Feb 25, 2020 19:41:26 GMT -5
Oh nice! This is it! Dry Powder Insufflator. Remember seeing a patent for this once... and, another boca raton resident. You must know boca gal |
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