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Post by jasper27 on Aug 8, 2020 9:12:12 GMT -5
It's time to break outside the Afrezza box because:
* Afrezza has yet to sell 1000 scripts per week and the compounding number effect of new users has never happened. (please -- we don't need more time or sales people -- been there and done that for years now) * Afrezza has yet to gain Tier 1 or 2 insurance coverage and likely never will. (even Mike C. seems to have given up hope on top tier coverage and doesn't even mention it anymore) * About 3 years ago Mike C. was saying "Pediatric approval is the key for Afrezza sales". (Then, year after year nothing much happens on the Pediatric front) Of course, Afrezza marketing was bad (Race cars and that awful floating hamburger commercial)
But, away from negatives and onto breaking outside the Afrezza box:
* Mike C. is a pharmacist, and was trained to be in a paper box or a pill bottle. (Thus, Mike C. needs to stop playing the Pharma game and sell elsewhere)
* Northrup, Lockheed and Grumman sell only to the government and nothing to individual people. (Mannkind could do that -- and sales would increase a thousand fold)
* Sell to the government health departments of a 100 small nations that only require FDA approval which we have
* In summary, stop selling to individual people.
Such an easy concept, but Mike C. is stuck in the Pharma box.
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Post by prcgorman2 on Aug 8, 2020 17:08:26 GMT -5
ZZZZzzzzzzz
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Post by cretin11 on Aug 8, 2020 18:12:29 GMT -5
Zzzzzzzz does describe MNKD share price action perfectly. |
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Post by prcgorman2 on Aug 8, 2020 18:30:30 GMT -5
ZZZZzzzzzz. also describes the 3 previous posts.
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Post by jasper27 on Aug 8, 2020 18:33:31 GMT -5
Zzzzzzzz whatever.
At least I'm trying to offer original thoughts and strategies.
Of course, I could talk about A1c and Hypos like 90% of the posts here --- now that ZZzzz boring.
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Post by prcgorman2 on Aug 8, 2020 18:36:57 GMT -5
You also used hyperbole such as “thousand fold”. Incredible. Seriously, not credible.
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Post by sportsrancho on Aug 8, 2020 19:17:49 GMT -5
You know guys on average 1600 people read Pro-boards within a 24 hour period, ..and only about 12 people post.... why do you think that is?
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Post by seanismorris on Aug 8, 2020 20:08:28 GMT -5
You know guys on average 1600 people read Pro-boards within a 24 hour period, ..and only about 12 people post.... why do you think that is? On your original comment. I think the problem selling to governments etc. is MannKinds insistence in pricing Afrezza at a premium. I broke away from the bulls on this board when the original rebranding came out. I thought it was terrible... because it was terrible. The same was true with the commercial. I’ve always pushed for Internet marketing. Increasing the sales team has only increased overhead. I (we) read but don’t post because nothing has changed. It’s the same dog and pony show for investors. The international sales plan was laughable, but it kept people from pulling their money out. Nothing pisses me off more than the pediatric study not having been completed by now. Afrezza didn’t show superiority in the other trials. The pediatric is key in convincing docs to prescribe regardless of age. We NEED this done. Bottom line, I think Mike doesn’t believe in Afrezza but has some hope in Technosphere. He’s going to drag things out as long as he can to see if that hope become a reality. I’m checking in regularly hoping to see you sportsrancho post “Pediatric Study Complete, Docs Blown Away” or “MannKind announces new partner”. Until then it’s just irrational bulls repeating themselves... |
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Post by jasper27 on Aug 8, 2020 20:37:29 GMT -5
Thanks Sports for showing support to a Newbie poster. You are right, about 12 people post here because people get slapped down.
But, my focus is Mannkind's success and offering unique thoughts. Seanismorris said "Afrezza won't sell to the government because it's premium priced" Wow, the government overpays for everything (think $4000 toilet seats) The VA and FEMA would order volume and not even look at the price.
I have a great background selling to the government and it's E-A-S-Y. (And better yet they bought more parts even when their shelves were full).
Al Mann never wanted to sell direct to individual users.
No, he wanted a BP or partner to do that.
Mike C. needs to revamp his strategy to government sales.
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Post by sportsrancho on Aug 8, 2020 23:06:09 GMT -5
Here’s an idea from Spencer... www.realclearpolitics.com/articles/2020/08/04/an_effective_covid_treatment_the_media_continues_to_besmirch_143875.htmlspencerosborne 8/7/20, 11:07 PM $MNKD a covid strategy for mankind. Read this article first. realclearpolitics.com/artic... 1. Assess whether HCQ and HCQ/zinc can work with technospere. This can be done quickly. If no, stop. If yes, continue. 2. Develop a study design that can assess 300 people in each arm. Make the design such that any side of the HCQ debate can save face for being right/wrong. State "early use"and key in on "lung delivery". The new delivery and early use allow the two sides to both have plausible reasons why they were wrong before, but right now. 3. Develop a "Covid-Kit". Effective treatment can happen in 13 doses. 3 doses on day 1 and then 2 doses a day for 5 days. While the dreamboat is reusable, ship 13 dreamboats, 13 cartridges, 13 sanitizer wipe pads, a pack of masks, and 13 sani-bags for disposal of materials in a safe and sanitary manner. 4. Go to government for assistance on financial costs and logistics of getting to patients in a controlled manner. spencerosborne 8/7/20, 11:16 PM 5. Preemptively work deals with big suppliers for sanitizer pads (think J&J), masks (think 3M), and disposal bags (think outside the box like SC Johnsons ziplock) this ties mannkind to 3 big names which never hurts. This gives mannkind credibility. It also demonstrates "outside the box" thinking, which is what mannkind is all about with lung delivery, thereby legitimizing the concept with help from non-pharma companies like 3M and SC Johnson. Pharma does not want to help mannkind, so go outside pharmacy. 6. Announce a ramp up of production in Connecticut, AND announce a dedicated square footage to the program (even if it is a lot of empty space). This makes a building that is currently underutilized suddenly utilized. The idea is to change Shipping 13 dreamboats makes factory use more efficient, and increases the revenue per kit. Adding sanitation wipes, sanitation collection bags, and masks also serve to increase revenues with the added benefit of allowing the company to collaborate with big players. Mannkind has the space to do the work, and can put together a nice Covid-Kit which could save lives and be profitable. The 3 big companies I mentioned are headquartered in Minnesota, Wisconsin, and New Jersey. Mannkind is California and Connecticut. Get those 10 senators on board, and every congressman. Both sides of the aisle to help push. A pipe dream....very well could be. It will take a vision, courage, and hard work to. By partnering with 3 bigger players for supplies in this, you get some major CEO's applying pressure in this. This not only represents a possible life saving solution, but also jobs. It could also change the dynamics of how some of these big companies think. Example, SC johnson dabbles in cleaning solutions/skin care. Might they want to expand into pharma? Perhaps a lucrative covid related deal that comes to fruition at the right moment, may spur a longer relationship. 1 million covid kits would pump out 13 million dreamboats. 10 million would be 130 million dreamboats. Now think global. Use existing partners in some other countries to Jumpstart Lastly, this could help afrezza. Afrezza works well, but the mainstream medical community poo-poo's it. HCQ/zinc work well, but the mainstream media and political players poo-poo simply because of politics. If an inhaled HCQ/zinc (given early) does well (allowing the naysayers to save face to get them on board is critical), then any inhaled product made by mannkind (afrezza) will need to get serious reconsideration from its naysayers. Inhaled insulin turned things on their head. Let inhaled HCQ/zinc do it again. Perhaps this can allow the science to be looked at with a new lens. |
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Post by boytroy88 on Aug 9, 2020 2:36:31 GMT -5
You know guys on average 1600 people read Pro-boards within a 24 hour period, ..and only about 12 people post.... why do you think that is? Well, if they are like me I just don't know enough to chime in on any of the medical/scientific/legal/corp side of things so I just lurk and try to absorb as much as possible. You know the saying about not saying anything so that people won't know that you are stupid instead of speaking and proving the point - or something like that. LOL |
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Post by morfu on Aug 9, 2020 7:10:17 GMT -5
Here’s an idea from Spencer... www.realclearpolitics.com/articles/2020/08/04/an_effective_covid_treatment_the_media_continues_to_besmirch_143875.htmlspencerosborne 8/7/20, 11:07 PM $MNKD a covid strategy for mankind. Read this article first. realclearpolitics.com/artic... 1. Assess whether HCQ and HCQ/zinc can work with technospere. This can be done quickly. If no, stop. If yes, continue. 2. Develop a study design that can assess 300 people in each arm. Make the design such that any side of the HCQ debate can save face for being right/wrong. State "early use"and key in on "lung delivery". The new delivery and early use allow the two sides to both have plausible reasons why they were wrong before, but right now. 3. Develop a "Covid-Kit". Effective treatment can happen in 13 doses. 3 doses on day 1 and then 2 doses a day for 5 days. While the dreamboat is reusable, ship 13 dreamboats, 13 cartridges, 13 sanitizer wipe pads, a pack of masks, and 13 sani-bags for disposal of materials in a safe and sanitary manner. 4. Go to government for assistance on financial costs and logistics of getting to patients in a controlled manner. spencerosborne 8/7/20, 11:16 PM 5. Preemptively work deals with big suppliers for sanitizer pads (think J&J), masks (think 3M), and disposal bags (think outside the box like SC Johnsons ziplock) this ties mannkind to 3 big names which never hurts. This gives mannkind credibility. It also demonstrates "outside the box" thinking, which is what mannkind is all about with lung delivery, thereby legitimizing the concept with help from non-pharma companies like 3M and SC Johnson. Pharma does not want to help mannkind, so go outside pharmacy. 6. Announce a ramp up of production in Connecticut, AND announce a dedicated square footage to the program (even if it is a lot of empty space). This makes a building that is currently underutilized suddenly utilized. The idea is to change Shipping 13 dreamboats makes factory use more efficient, and increases the revenue per kit. Adding sanitation wipes, sanitation collection bags, and masks also serve to increase revenues with the added benefit of allowing the company to collaborate with big players. Mannkind has the space to do the work, and can put together a nice Covid-Kit which could save lives and be profitable. The 3 big companies I mentioned are headquartered in Minnesota, Wisconsin, and New Jersey. Mannkind is California and Connecticut. Get those 10 senators on board, and every congressman. Both sides of the aisle to help push. A pipe dream....very well could be. It will take a vision, courage, and hard work to. By partnering with 3 bigger players for supplies in this, you get some major CEO's applying pressure in this. This not only represents a possible life saving solution, but also jobs. It could also change the dynamics of how some of these big companies think. Example, SC johnson dabbles in cleaning solutions/skin care. Might they want to expand into pharma? Perhaps a lucrative covid related deal that comes to fruition at the right moment, may spur a longer relationship. 1 million covid kits would pump out 13 million dreamboats. 10 million would be 130 million dreamboats. Now think global. Use existing partners in some other countries to Jumpstart Lastly, this could help afrezza. Afrezza works well, but the mainstream medical community poo-poo's it. HCQ/zinc work well, but the mainstream media and political players poo-poo simply because of politics. If an inhaled HCQ/zinc (given early) does well (allowing the naysayers to save face to get them on board is critical), then any inhaled product made by mannkind (afrezza) will need to get serious reconsideration from its naysayers. Inhaled insulin turned things on their head. Let inhaled HCQ/zinc do it again. Perhaps this can allow the science to be looked at with a new lens. "If an inhaled HCQ/zinc (given early) does well (allowing the naysayers to save face to get them on board is critical), " Well, the FDA says to that: "June 15, 2020 Update: Based on ongoing analysis and emerging scientific data, FDA has revoked the emergency use authorization (EUA) to use hydroxychloroquine and chloroquine to treat COVID-19 in certain hospitalized patients when a clinical trial is unavailable or participation is not feasible. We made this determination based on recent results from a large, randomized clinical trial in hospitalized patients that found these medicines showed no benefit for decreasing the likelihood of death or speeding recovery. This outcome was consistent with other new data, including those showing the suggested dosing for these medicines are unlikely to kill or inhibit the virus that causes COVID-19. As a result, we determined that the legal criteria for the EUA are no longer met. Please refer to the Revocation of the EUA Letter and FAQs on the Revocation of the EUA for Hydroxychloroquine Sulfate and Chloroquine Phosphate for more information."
Do you recommend to go against FDA and their medical advice? It seems there are studies showing that hydroxychloroquine is "unlikely to kill or inhibit the virus that causes COVID-19", but can have side effects that kill the patient, if true that proposal costs life and you might as well gurgle disinfectants like Trump suggested!
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Post by goyocafe on Aug 9, 2020 7:23:31 GMT -5
“Do you recommend to go against FDA and their medical advice? It seems there are studies showing that hydroxychloroquine is "unlikely to kill or inhibit the virus that causes COVID-19"...”
When I see the letters FDA, I cringe. I only have to look back at the MNKD/Afrezza ADCOM to realize how misguided they can be, and to the same effect what tail wags that dog! I also don’t believe anyone has claimed Hydroxychloroquine kills the COVID virus. I believe it is meant to act as a prophylactic, much like zinc, to help keep the virus from attaching and spreading in the body. Late stage disease is a very unlikely place to test this concept, but it doesn’t surprise me that the nay sayers would use such a study to completely rule out its use.
Considering there is no money in such a solution for big pharma only strengthens my opinion that there are conflicts of interest throughout the medical establishment as to what solution(s) should be promoted and when.
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Post by matt on Aug 9, 2020 8:00:03 GMT -5
On your original comment. I think the problem selling to governments etc. is MannKinds insistence in pricing Afrezza at a premium. I think that comment hits the nail on the head. I spent a good part of my career as a globe-trotter doing business in more than 40 countries for a major healthcare company. You would not believe just how price conscious most countries are when considering new products. Most of the world thinks the US is bat-&#*@ crazy for spending 18% of GDP on healthcare, and most countries have neither the financial resources nor the inclination to copy our bad example. Brazil, for example, provides free diabetic supplies to their entire population but they buy the insulin from state-government owned production facilities that sell injectable recombinant insulin for slightly less than $5 a vial (versus about $120 for a comparable amount of Humalog). Mannkind cannot produce Afrezza cheaply enough to be competitive, indeed if the price of Afrezza only covered the fully-burdened manufacturing cost (i.e. no gross profit at all) it would still be orders of magnitude more expensive than injectables and Mannkind would hemorrhage cash. Selling to 100 small countries that do not require an approval separate from that of the FDA would not help much. There are but a handful of petrostates that might be willing to eat the higher price, but most countries have a GDP per capita less than $15,000 (the US figure is roughly $65,000). Governments in countries with low GDP per capita only buy basic and essential healthcare products which is why major healthcare companies focus their marketing efforts on the US, Europe, Japan, China, India and a few other places. Just because a geography like Africa has 1.3 billion people does not mean the governments of Africa can afford Afrezza; they can't. |
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Post by agedhippie on Aug 9, 2020 8:31:35 GMT -5
“Do you recommend to go against FDA and their medical advice? It seems there are studies showing that hydroxychloroquine is "unlikely to kill or inhibit the virus that causes COVID-19"...” When I see the letters FDA, I cringe. I only have to look back at the MNKD/Afrezza ADCOM to realize how misguided they can be, and to the same effect what tail wags that dog! I also don’t believe anyone has claimed Hydroxychloroquine kills the COVID virus. I believe it is meant to act as a prophylactic, much like zinc, to help keep the virus from attaching and spreading in the body. Late stage disease is a very unlikely place to test this concept, but it doesn’t surprise me that the nay sayers would use such a study to completely rule out its use. Considering there is no money in such a solution for big pharma only strengthens my opinion that there are conflicts of interest throughout the medical establishment as to what solution(s) should be promoted and when. The problem would be that if it was to used as a prophylactic the trial group would need to be on the same scale as a vaccine trial. This then becomes a gamble that none of the vaccines work because they will all report first since they are already underway. I doubt 3M could be involved since they are already out of production capacity. Apparently Chinese mask producers have a surplus now... |
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