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Post by markado on Jun 28, 2021 15:56:51 GMT -5
Once Afrezza is approved for use for patients under 18...
"Until Afrezza, T1 insulin treatments hadn't changed significantly for generations (show needles and vials). Now, with a prescription for Afrezza (show inhaler and cartridges), multiple generations can significantly change their T1 treatments, with fewer injections, more time in range, lesser risk of hypoglycemia and greater quality of life!"
Show the above with imagery of a Grandparent, their son or daughter, and their grandson or grandaughter all pushing needles and vials to the side, then placing their inhalers and cartridges on the table.
Then end with, "Afrezza - inhalable, monomeric insulin - it's time to start treating T1 diabetes, differently!"
Then, the necessary legalese.
Once it moves to use for Peds, T2, just eliminate T1 from the statement/tag line, above.
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Post by boca1girl on Jun 28, 2021 16:31:03 GMT -5
.? Already approved for T2.
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Post by markado on Jun 28, 2021 18:53:31 GMT -5
.? Already approved for T2. Thx, BG. Just referring to the Peds portion of T2. I think there, those Peds patients that are using it are doing so off label? |
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Post by uvula on Jun 30, 2021 7:42:21 GMT -5
Perfect except remove the word monomeric. We know what it means but most people don't.
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Post by mytakeonit on Jun 30, 2021 13:50:07 GMT -5
So it means "One meric  " Not MTOI |
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Post by markado on Jun 30, 2021 20:58:35 GMT -5
Perfect except remove the word monomeric. We know what it means but most people don't. In my experience, Diabetics tend to be more informed patients and consumers of medical information. The more patients learn as to why Afrezza is different, and why works differently, the more that becomes the reason why they and others they tell then use it. Google searches for monomeric insulin would likely predominantly or only point to Afrezza based on search relevance. I'm no expert, but I like piquing curiosity and inspiring self-education that leads to understanding and advocacy. The perception that hexomeric insulin = barbaric (dated) injections, and that monomeric is less injurious and liberating, would be both accurate and beneficial. Jmo. |
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Post by uvula on Jul 1, 2021 6:45:25 GMT -5
Okay. I will allow you to use the word.
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Post by mnholdem on Jul 1, 2021 7:10:29 GMT -5
Insulin Levels Signal the Liver Whether More Glucose is Needed
The steady insulin level as another function, too. A dropping insulin level signals the liver that blood sugar is getting low and that it is time to add more glucose. When this happens, the liver converts the carbohydrate it has stored, (known as glycogen) into glucose, and dumps it into the blood stream. This raises the blood sugar back to its normal level.
If a person has exhausted their glycogen stores, as can happen on a low carbohydrate diet, the liver converts protein into glucose to provide the glucose it makes in response to a low level of insulin in the blood. The protein can come from dietary protein or from your body's own muscles. That is why dieters can lose significant amounts of muscle mass if they don't get enough protein when they diet.
First Phase Insulin Release
When a health person starts to eat a meal, the beta-cells kick into high gear. Their stored insulin is released immediately. Then, if the blood sugar concentration rises over 100 mg/dl, (5.5 mmol/L) the beta-cells start secreting more insulin into the blood stream. This early release of stored insulin after a meal is called "First Phase Insulin Release." In a healthy person it keeps the blood sugar from rising very high because it is available to meet most of the glucose that comes from the digestion of the current meal.
The amount of insulin secreted in the first phase response to a meal is usually determined by the amount of glucose encountered in the previous meal. In a healthy person, this first phase response peaks a few minutes after you've started your a meal. The blood sugar rise caused by the meal peaks about half an hour after you start eating.
Glucose Toxicity
Whatever the reason for the failing first phase insulin release there's an ugly feedback mechanism that kicks in when blood sugar levels rise because of that failing first phase insulin release: High levels of circulating glucose themselves are toxic to beta-cells, a phenomenon called "glucose toxicity". So as blood sugars rise these high blood sugar concentrations further damage and or kill more beta-cells, making first and second phase insulin release even less able to control blood sugar concentrations.
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Post by mnholdem on Jul 1, 2021 7:54:31 GMT -5
The excerpts above are from the thread Blood Sugar 101, which I wrote and posted in 2015 in this forum’s MNKD Resources section.
As stated in that post, there are dozens of causes for blood sugar problems and the plain truth is that what works for one person doesn’t also work for another. One fact that all people have in common is the importance of 1st Phase Insulin release. In my opinion, this is the most important benefit of Afrezza. Immediately signaling the liver to stop producing glucose results in less insulin needing to be released during 2nd Phase insulin release, since a person no longer has both sources (food and liver) raising blood sugar levels.
Ultra-Fast Afrezza insulin signals the liver to stop dumping sugar and, because Afrezza clears from the blood stream quickly, it can much safer to introduce a higher amount of insulin at the start of a meal. Afrezza won’t linger like injected insulin. The benefits are outlined in the post.
I believe that many endocrinologists are loathe to increase units of insulin because of the difficulty of predicting the absorption of injected insulin. Rightly so. Fat level at the injection site and the speed of the insulin are perhaps the two biggest factors. Endos limit units so avoid a dangerously low blood sugar level, aka hypoglycemia.
Because Afrezza is inhaled, the absorption of insulin into the bloodstream is VERY consistent. That can be a tremendous benefit to a person who wants to control his/her blood sugar levels.
This attribute of Afrezza could be a major disruptor when compared to today’s treatments. Disruptive marketing is expensive, both because it can be complicated when the FDA limits the dissemination of any information that hasn’t been clinically proven and because healthcare professionals often place caution first and take a lot of education to convince. MannKind has not sufficiently proven that its insulin is “safer” than other brands/types of insulin treatments and the FDA won’t allow them to even use the word “safer”.
It can be done if directed by an experienced and competent person. Emphasizing the benefits of consistency and speed are critical if the company ever hopes to grow adoption levels among healthcare professions and diabetes associations.
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Post by mnholdem on Jul 1, 2021 8:04:01 GMT -5
BTW, I do miss participating here. Domestic and international sales of the family of healthcare companies that I work for has exploded during the past several years, primarily because of better marketing. We’ve had great products for decades but had only recently implemented an aggressive marketing strategy to educate the market.
It keeps me extremely busy. I’m posting today because I’m on a well-deserved vacation at my lake cabin. I think I’ll go fishing now.
Good fortune to all.
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Post by centralcoastinvestor on Jul 1, 2021 9:26:16 GMT -5
BTW, I do miss participating here. Domestic and international sales of the family of healthcare companies that I work for has exploded during the past several years, primarily because of better marketing. We’ve had great products for decades but had only recently implemented an aggressive marketing strategy to educate the market. It keeps me extremely busy. I’m posting today because I’m on a well-deserved vacation at my lake cabin. I think I’ll go fishing now. Good fortune to all. It is great to see some posts from you again. I miss your very informative posts but you have a great reason. Nothing like having success in the companies you work for reducing the time you have to post. I would like to encourage you to post when you can as you always brought a very intelligent and researched perspective to this board. I wish you continued good fortune for both yourself and the companies you work for. |
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Post by itellthefuture777 on Jul 1, 2021 17:48:47 GMT -5
Healthy humans have a pancreas that makes Human monomeric active insulin
Afrezza is less then 30 seconds difference Then the healthy pancreas
No one in the industry was ever able to stabilize the active singular Monomeric insulin like the healthy pancreas
At Best over the last 100 years industry could only stabilize insulin by inactivating it and zinc bonding six monomers together otherwise known as Hexomeric insulin and injecting it
Their delivery process being injected localized the insulin and then it took the blood several hours to breakdown the six pack hexomers into active monomerics
The normal spike you would see in the healthy individual isn't present in the hexomer insulins..so you have a slow curve in and out of the body raising significant risk of hypoglycemia..
Industry tried to make it match mother natures speed to reduce the risk and align..but..they just couldn't do it...until Mannkind..and Al Mann..
Sol Steiner..sold Mannkind FDKP a known inert Nano Particle that self assembles and stabilizes active Monomeric insulin..
Al knew way back then.. as you know..now..this would disrupt and change diabetes...no one can match the speed of action in..or out...it's the closest thing to mother nature's own..
No shot..systemically delivered through a one cell this lung wall...fdkp is excreted out...active Monomeric human insulin delivered..10 min peaking..90 minutes to 1.5 hour completely out of the body based on dose size...superior glycemic controls significant reduction of risk of hypos..weight neutral..no site scaring..no shot..free cool looking disposable whistle sized inhalers..
Insulin is..one of the largest selling drugs in the world over 700 million diabetics by 2045...that's huge! But..Mannkinds FDKP (Technosphere) can load almost any drug..peptide..protein..with over $490 billion with of drugs that went off patent starting in 2011...just imagine all the repurposed drugs that can be loaded!...we are only at the beginning of the at stem cell of drugs..that Technosphere can become..This is the biggest Pharmaceutical opportunity in the history of pharma...enjoy the weekend fishing GLTA!
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Post by uvula on Jul 1, 2021 22:52:35 GMT -5
Itell, I don't disagree with anything you said. It is unfortunate that you could have (and probably did) write the same thing a decade ago, and we are still waiting.
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Post by itellthefuture777 on Jul 2, 2021 0:44:09 GMT -5
Itell, I don't disagree with anything you said. It is unfortunate that you could have (and probably did) write the same thing a decade ago, and we are still waiting. The future comes forth..but it just goes to show just how rare ole Al was in heart, sprit, brains, persistent..onry...but...Al was right..he's still right.. and they're still wrong..and we're still here..being that rock in the flow causing a disruptive wave..to diabetes..and the system that tries to push us down stream..can't..we're sitting on a solid foundation...Iron Mike at the wheel..this last week he was double and triple punching it..going for the title..he's been dialing it in..connecting..over the last 10 years the large Insulin makers have backed themselves into a corner of over priced old..slow wheel buggies..now selling them at Walmart as a LAST resort..their all washed up..they know it..we know it...they don't want to admit that a 90 year old man whooped them..but..he did..and so fast..it was like a Bruce Lea move..sure..they're still standing..but..we all know what happens next.. |
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Post by mytakeonit on Jul 2, 2021 1:59:28 GMT -5
Yes ... that I will have to get another 1M shares. Oh well, I need to feed all the homeless in Hawaii thru donations ... so this is the easiest way for me.
But, that's mytakeonit
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