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Post by falconquest on Apr 30, 2022 4:46:17 GMT -5
There are a lot of interesting aspects to the information here. This doesn't seem like a typical "the cure is just around the corner video". Check it out, I look forward to everyone's thoughts.
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Post by sportsrancho on Apr 30, 2022 6:07:40 GMT -5
Yes, Tom my friend with the first kids on Afrezza has been invested in that company for years.
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Post by sayhey24 on Apr 30, 2022 6:41:16 GMT -5
Jacob Petersen is asked about the possibility of losing $8B and Nova Nordisk is not worried about it in the least - SURE! I also though it interesting they showed Novalog in the video and not levemir or tresiba.
A number of research labs have been doing this for years but the problem is they are not getting to root cause. They talk numerous times about the ongoing autoimmune response and the need for ongoing immunosuppressants. What is causing this autoimmune issue which is killing the beta cells? Joslin years ago said they isolated a number of virus strains which were causing the problem. With covid we are seeing a lot more people developing diabetes after having the virus.
Is diabetes viral based - maybe. We know its not caused by that ice cream Brian had in the video. Is it worse taking insulin or taking these autoimmune drugs? Taking insulin is a known. With the autoimmunes maybe its like playing russian roulette.
For Brian he got 92% insulin production back "for some period of time" until his beta cells are destroyed again. During that time afrezza could really have helped him. We also know beta cells can be self regenerative if the "infection" subsides and the pancreas is "rested" - we see this with early insulin intervention in T2s and diet exercise in 60% of "prediabetics".
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Post by boca1girl on Apr 30, 2022 6:51:38 GMT -5
Glad to see that Afrezza was mentioned.
So the cure is 5 years away + 5 years + 5 years.
I was a bit surprised that some would for go the stem sell transfusion because of the need to take immune suppressants.
I was also surprised that Novo is not concerned with revenue loss if they could be successful.
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Post by boca1girl on Apr 30, 2022 7:30:14 GMT -5
Immunosuppressants can be scary. For example, Cellcept is used for auto-immune retinopathy. Package insert says, in my words: - patient is susceptible to infections. (What happens if I get Covid? Doc says "I will pump you up with antibodies".) (What happens if I get in a car wreck?) (What if I need surgery for appendix or prostate?) - don't go out in the sun or you get skin cancer. - some patients get a brain disease called PML. I know there are risks (as with any drug) but I have 35 years of experience taking an immune suppressant for an autoimmune disease. Maybe I’ve been lucky but I have well tolerated it. Yes, I do have higher risk for infection and do have low platelets (monthly blood test and costly diagnostic test, etc.). My doc jokes with me to stay away from chain saws, etc. |
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Post by peppy on Apr 30, 2022 8:06:31 GMT -5
Jacob Petersen is asked about the possibility of losing $8B and Nova Nordisk is not worried about it in the least - SURE! I also though it interesting they showed Novalog in the video and not levemir or tresiba. A number of research labs have been doing this for years but the problem is they are not getting to root cause. They talk numerous times about the ongoing autoimmune response and the need for ongoing immunosuppressants. What is causing this autoimmune issue which is killing the beta cells? Joslin years ago said they isolated a number of virus strains which were causing the problem. With covid we are seeing a lot more people developing diabetes after having the virus. Is diabetes viral based - maybe. We know its not caused by that ice cream Brian had in the video. Is it worse taking insulin or taking these autoimmune drugs? Taking insulin is a known. With the autoimmunes maybe its like playing russian roulette. For Brian he got 92% insulin production back "for some period of time" until his beta cells are destroyed again. During that time afrezza could really have helped him. We also know beta cells can be self regenerative if the "infection" subsides and the pancreas is "rested" - we see this with early insulin intervention in T2s and diet exercise in 60% of "prediabetics". Viral, I have learned about viruses........ Viral would not explain the multigenerational observations. Molly's father, Molly, and one of molly's sister. (they were three sisters.) |
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Post by sayhey24 on Apr 30, 2022 8:29:38 GMT -5
Peppy - of course it would based on genetic disposition to certain infections. Its also interesting because we see diabetes cluster hot spots which could potentially be explained by a some what closed community like Pottsville PA sharing some viral infection. We also have closed communities with the native americans which could be a combination of extended exposure to a virus plus a genetic disposition to the virus. Here is an overview from my "favorite" organization - read it with a grain of salt www.diabetes.org/diabetes/genetics-diabetesThe interesting questions are raised with identical twins - here is an overview from healthline www.healthline.com/diabetesmine/twins-and-diabetes#1Some of the Joslin research pointed to a virus which was ingested through food. Maybe? We don't know but as the healthline article says Thirty-five years later, her genetic double is still diabetes-free. “It fascinates me that we share 100% of the same genes, developed in the exact same womb and grew up in the exact same environment, eating the exact same things, having the same father who had type 1 — yet one of us has (T1D) and the other doesn’t, Covid raised all kinds of questions because now we have an airborne virus which is clearly impacting people and we are seeing a significant increase in diabetes. |
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Post by porkini on Apr 30, 2022 9:20:40 GMT -5
There are a lot of interesting aspects to the information here. This doesn't seem like a typical "the cure is just around the corner video". Check it out, I look forward to everyone's thoughts.
I had 5 minutes worth of time to watch the beginning of your 20 minute video. All I have time for right now. It would be nice if you would include at least the title of the video "How There Could Finally Be A Cure For Diabetes" and perhaps a short sentence regarding the content of the video. This will help keep the post from being removed when there is not time to immediately verify content. Thank you for your contribution. |
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Post by jkendra on May 3, 2022 8:09:52 GMT -5
www.marketwatch.com/story/vertex-pharma-fda-puts-vx-880-diabetes-study-on-hold-vrtx-271651495789?mod=investingFDA suspends early study of Vertex stem-cell therapy for type 1 diabetes Vertex Pharmaceuticals Inc. on Monday said the U.S. Food and Drug Administration has placed the company's Phase 1/2 study of VX-880 in type 1 diabetes on clinical hold after the agency determined there is insufficient information to support dose escalation with the product. The Boston drug maker said it was surprised by the FDA's action, and that it plans to work with the agency to understand and address its questions so the trial can resume at U.S. sites as soon as possible. Vertex, which is studying VX-880 as an insulin-producing islet cell therapy in people with type 1 diabetes with impaired hypoglycemic awareness and severe hypoglycemia, said two patients in Part A of the study received VX-880 at half the target dose, with positive data from those patients establishing proof-of-concept for VX-880. The company said a third patient has received the full target dose with initiation of Part B of the study, adding that VX-880 has been generally well tolerated in all three patients dosed to date. Shares of Vertex, which closed Friday at $273.33, fell 4.5%, to $261, in light premarket trading Monday.
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Post by peppy on May 3, 2022 8:12:28 GMT -5
www.marketwatch.com/story/vertex-pharma-fda-puts-vx-880-diabetes-study-on-hold-vrtx-271651495789?mod=investingFDA suspends early study of Vertex stem-cell therapy for type 1 diabetes Vertex Pharmaceuticals Inc. on Monday said the U.S. Food and Drug Administration has placed the company's Phase 1/2 study of VX-880 in type 1 diabetes on clinical hold after the agency determined there is insufficient information to support dose escalation with the product. The Boston drug maker said it was surprised by the FDA's action, and that it plans to work with the agency to understand and address its questions so the trial can resume at U.S. sites as soon as possible. Vertex, which is studying VX-880 as an insulin-producing islet cell therapy in people with type 1 diabetes with impaired hypoglycemic awareness and severe hypoglycemia, said two patients in Part A of the study received VX-880 at half the target dose, with positive data from those patients establishing proof-of-concept for VX-880. The company said a third patient has received the full target dose with initiation of Part B of the study, adding that VX-880 has been generally well tolerated in all three patients dosed to date. Shares of Vertex, which closed Friday at $273.33, fell 4.5%, to $261, in light premarket trading Monday. Sounds like the party is over. |
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