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Post by uvula on Jul 23, 2022 17:06:19 GMT -5
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Post by mymann on Jul 23, 2022 18:20:56 GMT -5
Afrin nasal spray is going to be repackaged and going to be sold for anaphylaxis treatment? |
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Post by uvula on Jul 23, 2022 18:27:44 GMT -5
Not sure if you are joking or not.
Afrin is not epinephrine, it is Oxymetazoline Hydrochloride.
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Post by mymann on Jul 23, 2022 18:52:18 GMT -5
Not sure if you are joking or not. Afrin is not epinephrine, it is Oxymetazoline Hydrochloride. [br Joking of course out of frustration. I only brought up Afrin nasal spray because of similiar properly of vasoconstriction. |
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Post by peppy on Jul 23, 2022 19:40:22 GMT -5
Geez, uvula, I am not sure. What do you think happened to technosphere epinephrine? You have been regularly on this board for years. |
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Post by uvula on Jul 23, 2022 21:48:29 GMT -5
The search function doesn't work properly. If you search for epinephrine you get tons of irrelevant threads. I seem to recall we didn't have the money at the time to conduct trials so we were hoping a partner would materialize. A few years ago this was going to make us rich. The share price then was probably higher than it is now.
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Post by peppy on Jul 23, 2022 22:47:04 GMT -5
The search function doesn't work properly. If you search for epinephrine you get tons of irrelevant threads. I seem to recall we didn't have the money at the time to conduct trials so we were hoping a partner would materialize. A few years ago this was going to make us rich. The share price then was probably higher than it is now. Correct, a partner never stepped up to the plate. If a partner were to step up to the plate, MNKD would manufacture it for them. MNKD has the secret recipe. That is my take. BTW, I knew you knew and you were just playing with us. A bit cat and mouse... |
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Post by uvula on Jul 24, 2022 7:54:12 GMT -5
I guess I'm just frustrated. Mnkd developed a needle free epinephrine and did nothing with it. A lot of money is being spent to develop a different needle free version instead of partnering with mnkd.
My guess is a technosphere powder gets into the bloodstream faster than an inhaled liquid. But I don't know if this is true or significant for epinephrine.
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Post by anderson on Jul 24, 2022 9:34:13 GMT -5
I though there was some conspiracy theory that amphastar wanted it dropped due to the possibility it might compete with primatene mist and that is why they didn't hold MNKD's feet to the fire to bad with the supply agreement. Not that I believe that, but when they finally make a movie about MNKD's success that should be the angle.
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Post by cretin11 on Jul 24, 2022 10:04:24 GMT -5
Agree, if they ever make a movie about MNKD, conspiracy theory is the best angle.
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Post by hopingandwilling on Jul 24, 2022 11:59:30 GMT -5
Uvula,
Since you asked the question I will answer it, knowing I will get flamed for sharing the details. This event was the straw that broke the camel’s back, and I sold my small position in the stock. After years of promoting this drug’s development, in a terse message, they announced they were dropping their effort because, after consultation with the FDA, the FDA informed MNKD that if they submitted an NDA for the drug and if the FDA decided to approve it-they would stipulate that with each prescription for such a product, MNKD would have to provide an Epi-Pen. For those undergoing such a crisis condition (life or death) the FDA didn’t think users would be 100% capable of dosing with an inhaler. Those undergoing such an attack, are rapidly unable to breathe, and thus, they can’t inhale or manually load the inhaler with the needed capsule of medication. Fumble this process and spill the medication out of the inhaler. Game over! With the epi-pen, a simple process—remove the outer cap and push the needle into their body.
It would not have been economically feasible for MNKD to furnish a free epi-pen with their prescription.
There was no conspiracy in this decision—simple science and human involvement led the FDA to make this decision.
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Post by sportsrancho on Jul 24, 2022 13:13:52 GMT -5
Agree, if they ever make a movie about MNKD, conspiracy theory is the best angle. I can’t wait for the one chapter we’ll write together. #We’veGotTheNotes |
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Post by uvula on Jul 24, 2022 14:13:45 GMT -5
Uvula, Since you asked the question I will answer it, knowing I will get flamed for sharing the details. This event was the straw that broke the camel’s back, and I sold my small position in the stock. After years of promoting this drug’s development, in a terse message, they announced they were dropping their effort because, after consultation with the FDA, the FDA informed MNKD that if they submitted an NDA for the drug and if the FDA decided to approve it-they would stipulate that with each prescription for such a product, MNKD would have to provide an Epi-Pen. For those undergoing such a crisis condition (life or death) the FDA didn’t think users would be 100% capable of dosing with an inhaler. Those undergoing such an attack, are rapidly unable to breathe, and thus, they can’t inhale or manually load the inhaler with the needed capsule of medication. Fumble this process and spill the medication out of the inhaler. Game over! With the epi-pen, a simple process—remove the outer cap and push the needle into their body. It would not have been economically feasible for MNKD to furnish a free epi-pen with their prescription. There was no conspiracy in this decision—simple science and human involvement led the FDA to make this decision. The fda comment sounds reasonable and plausible, but I don't recall ever hearing about this from mnkd. I'm not doubting you but I don't know you. Are there any published sources we can check? I wonder if the nasal drug will also need to be paired with an epipen. |
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Post by liane on Jul 24, 2022 16:04:41 GMT -5
uvula - FWIW - I don't remember such a comment either.
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Post by peppy on Jul 25, 2022 7:43:47 GMT -5
I guess I'm just frustrated. Mnkd developed a needle free epinephrine and did nothing with it. A lot of money is being spent to develop a different needle free version instead of partnering with mnkd. My guess is a technosphere powder gets into the bloodstream faster than an inhaled liquid. But I don't know if this is true or significant for epinephrine. I witnessed a code once where epinephrine was put down the endo tracheal tube. The person was on a ventilator. same difference in my book. Normally in that situation epi is given IV. |
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