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Post by agedhippie on Mar 19, 2023 9:33:22 GMT -5
Wow - now you are trying to blame rising blood glucose as the cause for resistance. Lol. Focus! Your question was why does it take more insulin to bring down a high spike. The answer is the down regulation of receptors. You are assuming that it takes the same number of units to reduce your level from, say, 300 to 200 as it does from 200 to 100. That's untrue. It takes more insulin to go from 300 to 200 despite that fact that in both cases there is a drop of 100. Welcome to my world, this is just one of those interesting quirks that make management so much harder than people think. You don't seem to have got past the introduction, not that it matters because the medical world has. If this is about you wanting to feel that you have solved diabetes if only the world would listen then mission accomplished. If you actually want to solve diabetes then you need to produce a paper that survives peer review and start socializing it in the medical community
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Post by sayhey24 on Mar 19, 2023 12:22:17 GMT -5
Wow - now you are trying to blame rising blood glucose as the cause for resistance. Lol. Focus! Your question was why does it take more insulin to bring down a high spike. The answer is the down regulation of receptors. You are assuming that it takes the same number of units to reduce your level from, say, 300 to 200 as it does from 200 to 100. That's untrue. It takes more insulin to go from 300 to 200 despite that fact that in both cases there is a drop of 100. Welcome to my world, this is just one of those interesting quirks that make management so much harder than people think. You don't seem to have got past the introduction, not that it matters because the medical world has. If this is about you wanting to feel that you have solved diabetes if only the world would listen then mission accomplished. If you actually want to solve diabetes then you need to produce a paper that survives peer review and start socializing it in the medical community Lets focus from now on on what we can show and solve. I can not prove to you Covid did not start from the under cooked batburger nor the raccoon dog. What I can show is if we "Stop the Spike" with afrezza we need 2x 3x less. You are also convinced that high blood sugar is causing insulin resistant. So, if we stop the high blood sugar by stopping the spike I would think we should be able to solve the insulin resistance issue. In other words "You" have solved the problem and afrezza should provide a path towards stopping the progression and reversing the disease. Agreed? For afrezza in 2023 Mike has a well defined plan; the kids study (T1); the ABC Big Trial (T1); India Results (T2); and making sure its on the 2024 Medicare formularity (T2) For 2024; the kids study results; ABC Study results; supporting Medicare CGMs sales through afrezza prescriptions. If Mike can get that done afrezza should be in a good place by 2024. The other big thing for the T2s which I would like done asap is the GLP1/afrezza study. Having those results for commercial sales once the Medicare results start showing great results would be huge. Knowing CGM vendors need to mainstream early insulin usage we should start to see some T2 SoC change for earlier insulin adoption and greater acceptance for early use.
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Post by agedhippie on Mar 19, 2023 13:09:49 GMT -5
What I can show is if we "Stop the Spike" with afrezza we need 2x 3x less. You are also convinced that high blood sugar is causing insulin resistant. So, if we stop the high blood sugar by stopping the spike I would think we should be able to solve the insulin resistance issue. In other words "You" have solved the problem and afrezza should provide a path towards stopping the progression and reversing the disease. Agreed? I actually curious about the 2x to 3x less insulin claim. Is there supporting trail data for that? And does that include getting back to baseline? I am not sure I have seen that paper. You are confusing acute and chronic insulin resistance. Chronic insulin resistance is what means you at say 200 need a carb ration of maybe 1u per 3g of carbs vs. 1u per 20g of carbs, its the underlying condition. The acute case is what I was talking about where the ratio itself fluctuates and that is caused by down regulation (read the paper) so that 1:20 ration becomes a 1:15 ratio at 350, but as soon as you drop back to 200 you will revert to 1:20 because the down regulation is no longer occurring. I can see a path to using less insulin in the acute case since you are not reaching as far into down regulation so you remain more insulin sensitive and need less insulin, however the baseline (chronic) insulin resistance is untouched. There is no evidence I know of currently that Afrezza addresses the chronic case (which is the one doctors care about), just theories and assertions, so write the paper that proves it.
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