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Post by hellodolly on Jun 6, 2023 14:08:36 GMT -5
Why not do the work needed and target the kids who are obese? Once the kids start taking it, the adults will, too. 1 INDICATIONS AND USAGE OZEMPIC® is indicated: • as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. www.novo-pi.com/ozempic.pdfPerhaps I miss understood what was being asked. MNKD target kids. Ozempic is for adults, correct? I wasn't asking/quoting you, I was making an open comment about MNKD going after the PEDS market for weight loss/obesity in kids.
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Post by peppy on Jun 6, 2023 14:16:05 GMT -5
sayhey24, help me out here, which group of relatively new diabetic medications had people, "pee" out their extra blood glucose? I can not recall. What medication was it? "Love your numbers, miss your legs?" mango
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Post by sayhey24 on Jun 6, 2023 14:35:08 GMT -5
sayhey24 , help me out here, which group of relatively new diabetic medications had people, "pee" out their extra blood glucose? I can not recall. What medication was it? "Love your numbers, miss your legs?" mango Peppy - SGLT2s are so yesterday. When GLP1s got the bump in the T2 SoC they are the hot step 2 after metformin Bexagliflozin (Brenzavvy) Canagliflozin (Invokana) Dapagliflozin (Farxiga) Empagliflozin (Jardiance) Ertugliflozin (Steglatro)
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Post by sayhey24 on Jun 6, 2023 14:43:35 GMT -5
1 INDICATIONS AND USAGE OZEMPIC® is indicated: • as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. www.novo-pi.com/ozempic.pdfPerhaps I miss understood what was being asked. MNKD target kids. Ozempic is for adults, correct? I wasn't asking/quoting you, I was making an open comment about MNKD going after the PEDS market for weight loss/obesity in kids. The sweet spot for GLP1 diet sales are 25-44 year old females. They are wage earners and can afford the hefty price tag.
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Post by peppy on Jun 6, 2023 15:05:07 GMT -5
MNKD target kids. Ozempic is for adults, correct? I wasn't asking/quoting you, I was making an open comment about MNKD going after the PEDS market for weight loss/obesity in kids. The sweet spot for GLP1 diet sales are 25-44 year old females. They are wage earners and can afford the hefty price tag. Novo Nordisk should run another trial, a weight loss trial and add a weight loss indication. Like Keytruda, must be 20 indications or more.
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Post by sayhey24 on Jun 6, 2023 15:12:32 GMT -5
The sweet spot for GLP1 diet sales are 25-44 year old females. They are wage earners and can afford the hefty price tag. Novo Nordisk should run another trial, a weight loss trial and add a weight loss indication. Like Keytruda, must be 20 indications or more. They already rebranded Ozempic as Wegovy and juiced the dosage.
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Post by mango on Jun 6, 2023 15:17:37 GMT -5
I think there’s a study showing IV administration of GLP-1 restores first phase insulin secretion. Administration via inhalation using MannKind’s inhaler with Technosphere GLP-1 it would mimic intra-arterial administration and have the same restoration of the first phase like that in the IV study. Maybe even better results.
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Post by peppy on Jun 6, 2023 15:28:11 GMT -5
I think there’s a study showing IV administration of GLP-1 restores first phase insulin secretion. Administration via inhalation using MannKind’s inhaler with Technosphere GLP-1 it would mimic intra-arterial administration and have the same restoration of the first phase like that in the IV study. Maybe even better results. The author said, GLP-1 made by the body in the body lasts minutes.The drug has been made to not deteriorate. The half life has to be long. I'll look. Here it is, 10 OVERDOSAGE In the event of overdose, appropriate supportive treatment should be initiated according to the patient’s clinical signs and symptoms. A prolonged period of observation and treatment for these symptoms may be necessary, taking into account the long half-life of OZEMPIC® of approximately 1 week.
" Administer OZEMPIC® once weekly, on the same day each week, at any time of the day, with or without meals. • The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours). • If a dose is missed, administer OZEMPIC® as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule. www.novo-pi.com/ozempic.pdf
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Post by agedhippie on Jun 6, 2023 16:44:48 GMT -5
I think there’s a study showing IV administration of GLP-1 restores first phase insulin secretion. Administration via inhalation using MannKind’s inhaler with Technosphere GLP-1 it would mimic intra-arterial administration and have the same restoration of the first phase like that in the IV study. Maybe even better results. The author said, GLP-1 made by the body in the body lasts minutes.The drug has been made to not deteriorate. The half life has to be long. I'll look. Here it is, 10 OVERDOSAGE In the event of overdose, appropriate supportive treatment should be initiated according to the patient’s clinical signs and symptoms. A prolonged period of observation and treatment for these symptoms may be necessary, taking into account the long half-life of OZEMPIC® of approximately 1 week.
" Administer OZEMPIC® once weekly, on the same day each week, at any time of the day, with or without meals. • The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours). • If a dose is missed, administer OZEMPIC® as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule. www.novo-pi.com/ozempic.pdfThe GLP-1 drugs on the market today are GLP-1 analogs engineered for an extended half life rather than actual GLP-1.
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Post by agedhippie on Jun 6, 2023 17:00:02 GMT -5
Why not do the work needed and target the kids who are obese? Once the kids start taking it, the adults will, too. 1 INDICATIONS AND USAGE OZEMPIC® is indicated: • as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. www.novo-pi.com/ozempic.pdfPerhaps I miss understood what was being asked. That work has already been done for kids. The trial (NCT04102189) wrapped up in January so I would be shocked if the application for a label change isn't already filed with the FDA.
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Post by agedhippie on Jun 6, 2023 17:15:08 GMT -5
Ozempic is very popular. All of us who have never used the drug should probably stop claiming the side effects are terrible and/or horrible. Every drug data sheet lists every potential side effect, including Afrezza. The reality is that many people like it. The reality is it comes with a very serious Black Box Warnings, along with serious potential side effects and also horrific post marketing adverse events. I have not seen a single social media post praising this drug. I know why. Funnily enough the source of Ozempic's popularity was social media, specifically TikTok. A quick look and there are 1.1B view for #ozempic. Of course Elon Musk praising it and crediting it with his weight loss didn't do any harm either, but this was primarily driven by social media posts.
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Post by peppy on Jun 6, 2023 18:13:33 GMT -5
The reality is it comes with a very serious Black Box Warnings, along with serious potential side effects and also horrific post marketing adverse events. I have not seen a single social media post praising this drug. I know why. Funnily enough the source of Ozempic's popularity was social media, specifically TikTok. A quick look and there are 1.1B view for #ozempic. Of course Elon Musk praising it and crediting it with his weight loss didn't do any harm either, but this was primarily driven by social media posts. they could TiK Tok all they wanted, if it wasn't for the weight loss, who would care. One thing that catches women attention is weight loss. We all want to be twiggy. And women are willing to pay to play that game. I have never looked so good in clothes, weehaw.
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Post by sayhey24 on Jun 6, 2023 18:20:25 GMT -5
The reality is it comes with a very serious Black Box Warnings, along with serious potential side effects and also horrific post marketing adverse events. I have not seen a single social media post praising this drug. I know why. Funnily enough the source of Ozempic's popularity was social media, specifically TikTok. A quick look and there are 1.1B view for #ozempic. Of course Elon Musk praising it and crediting it with his weight loss didn't do any harm either, but this was primarily driven by social media posts. I am expecting the same with afrezza and the kids. I expect the moms to make the market for pediatric use through social media. Now that Ozempic has shown us the way on TikTok maybe that will be one of the main platforms for the moms. It was only after I saw it starting to explode on social media that I realized the big market for GLP1s was in the diet space. Thats when I started searching for whatever happened to TS GLP1. Who knows maybe we get an announcement during ADA2023.
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Post by agedhippie on Jun 6, 2023 19:02:35 GMT -5
Funnily enough the source of Ozempic's popularity was social media, specifically TikTok. A quick look and there are 1.1B view for #ozempic. Of course Elon Musk praising it and crediting it with his weight loss didn't do any harm either, but this was primarily driven by social media posts. they could TiK Tok all they wanted, if it wasn't for the weight loss, who would care. One thing that catches women attention is weight loss. We all want to be twiggy. And women are willing to pay to play that game. I have never looked so good in clothes, weehaw. Absolutely. TikTok was focused entirely on weight loss and Ozempic as a wonder drug for weight loss. As a matter of interest I looked up last month's TRx - 2.5M prescriptions.
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Post by peppy on Jun 6, 2023 19:06:30 GMT -5
Novo Nordisk should run another trial, a weight loss trial and add a weight loss indication.Like Keytruda, must be 20 indications or more. They already rebranded Ozempic as Wegovy and juiced the dosage.——— INDICATIONS AND USAGE ——— WEGOVY® is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in: • adult patients with an initial body mass index (BMI) of • 30 kg/m2 or greater (obesity) or • 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia) (1). • pediatric patients aged 12 years and older with an initial BMI at the 95th percentile or greater for age and sex (obesity) (1).
WARNING: RISK OF THYROID C−CELL TUMORS See full prescribing information for complete boxed warning. • In rodents, semaglutide causes thyroid C-cell tumors at clinically relevant exposures. It is unknown whether WEGOVY® causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined (5.1, 13.1). • WEGOVY® is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors (4, 5.1). So no insurance coverage? www.novo-pi.com/wegovy.pdf
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