|
Post by agedhippie on Jun 6, 2023 21:29:55 GMT -5
... • pediatric patients aged 12 years and older with an initial BMI at the 95th percentile or greater for age and sex (obesity) (1).
... It looks like they already got the pediatrics label from that trial.
|
|
|
Post by mango on Jun 7, 2023 5:50:18 GMT -5
They already rebranded Ozempic as Wegovy and juiced the dosage.——— INDICATIONS AND USAGE ——— WEGOVY® is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in: • adult patients with an initial body mass index (BMI) of • 30 kg/m2 or greater (obesity) or • 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia) (1). • pediatric patients aged 12 years and older with an initial BMI at the 95th percentile or greater for age and sex (obesity) (1).
WARNING: RISK OF THYROID C−CELL TUMORS See full prescribing information for complete boxed warning. • In rodents, semaglutide causes thyroid C-cell tumors at clinically relevant exposures. It is unknown whether WEGOVY® causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined (5.1, 13.1). • WEGOVY® is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors (4, 5.1). So no insurance coverage? www.novo-pi.com/wegovy.pdfThe side effects and adverse events associated with this drug would scare me away from ever using it. Makes me wonder why physicians are so adamant to prescribe this. It is really fascinating. Look at the post marketing adverse events. One of our employees is on this drug. Vomiting, cramping, low energy, loss of appetite. Has not lost any weight. Is lazy weight loss really worth the potential harms? Aim: Nonadherence to glucagon-like peptide-1 receptor agonists (GLP1 RAs) is relatively common among patients with type 2 diabetes mellitus (T2DM). This study sought to identify reasons why patients discontinue GLP1 RAs. Materials and methods: Retrospective data from the Adelphi Diabetes Disease Specific Programme were used. Physicians managing patients with T2DM were surveyed via face-to-face interviews, and patients treated for T2DM were surveyed via self-completed questionnaires. Patient data were stratified by current versus prior GLP1 RA use. Results: Physicians (n=443) most frequently reported inadequate blood glucose control (45.6%), nausea/vomiting (43.8%), and gastrointestinal (GI) side effects (36.8%) as reasons for GLP1 RA discontinuation. Patients (n=194) reported the GI-related issues “Made me feel sick” (64.4%) and “Made me throw up” (45.4%) as their top reasons for discontinuation. The most common problems reported (excluding cost) for those currently using GLP1 RAs were “Prefer oral medication over injections” (patients 56%, physicians 32.6%), “Made me feel sick” (patients 38.1%, physicians 16.3%), and “Did not help lose weight” (patients 25.4%, physicians 18%). The most bothersome problems for patients globally (frequency reporting very/extremely bothersome) (excluding cost) were “Difficult to plan meals around” (55.6%), “Made me throw up” (51.6%), and “Caused weight gain” (50%). Conclusion: Both patients and physicians reported GI-related issues as a prominent factor, but disparities between patient experiences and physician perceptions were revealed, suggesting gaps in physician–patient communication. Understanding patients’ expectations of GLP1 RAs and physicians’ patient-management practices may help increase GLP1 RA adherence and thereby potentially enhance diabetes care. www.dovepress.com/reasons-for-discontinuation-of-glp1-receptor-agonists-data-from-a-real-peer-reviewed-fulltext-article-DMSO
|
|
|
Post by prcgorman2 on Jun 7, 2023 6:21:25 GMT -5
|
|
|
Post by mango on Jun 7, 2023 6:55:31 GMT -5
GLP-1s (all of them including Ozempic) were on the FDA Serious Adverse Events List not long ago for intestinal obstruction.
It will be obvious to me why Mike may never pursue this. The safety profile for GLP-1s is horrific. It’s fascinating how some drugs get approved.
|
|
|
Post by lennymnkd on Jun 7, 2023 7:11:38 GMT -5
And they advertise !
|
|
|
Post by sportsrancho on Jun 7, 2023 7:48:55 GMT -5
GLP-1s (all of them including Ozempic) were on the FDA Serious Adverse Events List not long ago for intestinal obstruction. It will be obvious to me why Mike may never pursue this. The safety profile for GLP-1s is horrific. It’s fascinating how some drugs get approved. I stopped reading this thread because it sickened me …but thank you! There are no shortcuts.
|
|
|
Post by stevil on Jun 7, 2023 9:25:09 GMT -5
Mounjaro will put the GLP-1s out of business once it gets better coverage.
It’s proving to be the holy grail so far. If it doesn’t cause any long term side effects, it will have the potential to be the best selling drug of all time… until the next GIP comes out.
As a doctor, I don’t want to give my patients any unnatural chemicals. However, the thing people on this thread don’t realize is that it’s not safe/healthy to be obese, either. It’s not that I’m gunning to ram these into peoples arms. But when my patients are telling me they have tried 10 different diets and exercise every day- some I believe, others I don’t … at all. But GIP restores the body’s insulin sensitivity back to physiological levels. It basically undoes the problem caused by poor diet and lack of exercise.
Again, is this the option I personally would choose for my patients. Not a chance in hell. But do I give it to all the right patients? Without hesitation. This drug is stupid good.
I must have all the statistical outliers in my practice… my patients are only sick during the first month of loading dose. After that, they have virtually no symptoms unless we keep titrating up. Then it’s only the day of and maybe after the dose.
|
|
|
Post by peppy on Jun 7, 2023 10:02:02 GMT -5
Mounjaro will put the GLP-1s out of business once it gets better coverage. It’s proving to be the holy grail so far. If it doesn’t cause any long term side effects, it will have the potential to be the best selling drug of all time… until the next GIP comes out. As a doctor, I don’t want to give my patients any unnatural chemicals. However, the thing people on this thread don’t realize is that it’s not safe/healthy to be obese, either. It’s not that I’m gunning to ram these into peoples arms. But when my patients are telling me they have tried 10 different diets and exercise every day- some I believe, others I don’t … at all. But GIP restores the body’s insulin sensitivity back to physiological levels. It basically undoes the problem caused by poor diet and lack of exercise. Again, is this the option I personally would choose for my patients. Not a chance in hell. But do I give it to all the right patients? Without hesitation. This drug is stupid good. I must have all the statistical outliers in my practice… my patients are only sick during the first month of loading dose. After that, they have virtually no symptoms unless we keep titrating up. Then it’s only the day of and maybe after the dose. MOUNJARO® is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. (1) Mounjaro® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Mounjaro is available by prescription only. ==================================================================================================================== Ozempic® is a registered trademark of Novo Nordisk A/S. DESCRIPTION OZEMPIC® (semaglutide) injection, for subcutaneous use, contains semaglutide, a human GLP-1 receptor agonist (or GLP-1 analog). The peptide backbone is produced by yeast fermentation. ======================================================================================================== stevil, Mounjaro packing a 1,2, punch?
|
|
|
Post by mango on Jun 7, 2023 10:33:55 GMT -5
Most people don’t know what healthy eating and working out even is. If you’re on a “diet” and working out consistently and not making any progress then you’re doing it incorrectly. Why prescribe dangerous drugs instead of getting on a proper health fitness program that produces results and can be sustained over years? It amazes me how quickly we prescribe drugs instead of going the healthy route. We’re just incentivizing and breeding lazy humans.
|
|
|
Post by peppy on Jun 7, 2023 13:24:53 GMT -5
Most people don’t know what healthy eating and working out even is. If you’re on a “diet” and working out consistently and not making any progress then you’re doing it incorrectly. Why prescribe dangerous drugs instead of getting on a proper health fitness program that produces results and can be sustained over years? It amazes me how quickly we prescribe drugs instead of going the healthy route. We’re just incentivizing and breeding lazy humans. I want to point out the obvious. We got our first computer in 1996........ 27 years. Office work or computer work/play/addiction is sedentary.We are not eating oatmeal in the morning and a sandwich in the afternoon and soup for dinner. Snacky poo, I love you.
|
|
|
Post by sayhey24 on Jun 7, 2023 15:33:09 GMT -5
Mounjaro will put the GLP-1s out of business once it gets better coverage. It’s proving to be the holy grail so far. If it doesn’t cause any long term side effects, it will have the potential to be the best selling drug of all time… until the next GIP comes out. As a doctor, I don’t want to give my patients any unnatural chemicals. However, the thing people on this thread don’t realize is that it’s not safe/healthy to be obese, either. It’s not that I’m gunning to ram these into peoples arms. But when my patients are telling me they have tried 10 different diets and exercise every day- some I believe, others I don’t … at all. But GIP restores the body’s insulin sensitivity back to physiological levels. It basically undoes the problem caused by poor diet and lack of exercise. Again, is this the option I personally would choose for my patients. Not a chance in hell. But do I give it to all the right patients? Without hesitation. This drug is stupid good. I must have all the statistical outliers in my practice… my patients are only sick during the first month of loading dose. After that, they have virtually no symptoms unless we keep titrating up. Then it’s only the day of and maybe after the dose. Stevil - it sounds like we are in violent agreement on Mounjaro. Early last year we started making the Mounjaro predictions right here on Proboards. We also predicted Lilly would make ADA2022 all about Mounjaro. When it comes to diabetes I am not a big GLP1 or GIP/GLP1(Mounjaro) fan. Nothing beats afrezza for mealtime glucose control. As Mike mentioned a few calls back when talking about the afrezza/glp1 trial is A1cs after 2 years for GLP1 users are about back to where they were for most of the users. I think this is the fact that finally got Mike's attention along with some preliminary afrezza numbers out of India showing 1.5-2% A1c reduction with afrezza. The big win is in the first year and then its all down hill. Most actually stop using within 2 years based on an insurance study. I don't think Mounjaro will do much better for diabetes with the long term results than Ozempic but we will know more next year. When it comes to the diet industry thats another story. I know some on this board like Sports don't like the idea of "diet pills". The reality is the "diet pill" industry has been booming since the late 1800's. Fen-phen sold 18million scripts in 1992 and Aged just mentioned Ozempic sold 2.5m last month and I am guessing most are for diet and not diabetes. I think Peter Richardson was on to something putting GLP1 on technosphere and when I say GLP1 I am lumping the GIP/GLP1 in with that. I find it interesting you see value in Mounjaro as a "diet pill" - stupid good? What if Technosphere could make it a more "marketable" stupid good diet pill - no shots and less side effects? Inhaling these days is sexy. A shot in the belly not so much. Would you prescribe Mounjaro DPI?
|
|
|
Post by mango on Jun 7, 2023 15:45:54 GMT -5
Most people don’t know what healthy eating and working out even is. If you’re on a “diet” and working out consistently and not making any progress then you’re doing it incorrectly. Why prescribe dangerous drugs instead of getting on a proper health fitness program that produces results and can be sustained over years? It amazes me how quickly we prescribe drugs instead of going the healthy route. We’re just incentivizing and breeding lazy humans. I want to point out the obvious. We got our first computer in 1996........ 27 years. Office work or computer work/play/addiction is sedentary.We are not eating oatmeal in the morning and a sandwich in the afternoon and soup for dinner. Snacky poo, I love you. If you have a sedentary job then you workout in the AM or PM before or after work. Meal prep and bring your own healthy food to work. Been doing it for years. What is discipline? Can we teach lazy, obese adults about being disciplined or do we prescribe them dangerous drugs?
|
|
|
Post by lennymnkd on Jun 7, 2023 16:03:29 GMT -5
Mango we’re do you live , in a gated community! Did you ever get a look A the general population out there ..not pretty. don’t think a fair amount of them have the discipline.
|
|
|
Post by agedhippie on Jun 7, 2023 16:56:21 GMT -5
... stevil , Mounjaro packing a 1,2, punch? Effectively yes. The added benefit is that GIP helps with nausea (they use it with some chemotherapy) as well as it's glucose management properties. Mounjaro will take over from Ozempic, but I suspect Novo Nordisk is already working on their version.
|
|
|
Post by sayhey24 on Jun 7, 2023 17:10:45 GMT -5
I want to point out the obvious. We got our first computer in 1996........ 27 years. Office work or computer work/play/addiction is sedentary.We are not eating oatmeal in the morning and a sandwich in the afternoon and soup for dinner. Snacky poo, I love you. If you have a sedentary job then you workout in the AM or PM before or after work. Meal prep and bring your own healthy food to work. Been doing it for years. What is discipline? Can we teach lazy, obese adults about being disciplined or do we prescribe them dangerous drugs? Mango - it sounds like you will not be a candidate my Mounjaro DPI but what would MNKD's pps be if it got 10% of last months Ozempic sales? Aged said for Ozempic - last month's TRx - 2.5M prescriptions. Assuming $1k a script thats a lot of moolah. Even 10% of that ain't bad and a lot more than Tyvaso DPI will ever be.
|
|