Clofazimine and SARS-CoV2

[mango]

In one of the slides Mike presented on Clofazimine it mentions expanding into other indications within the Infectious Disease Category.

I present a patent by MannKind indicated for the treatment of SARS-CoV2 using Clofazimine:
CLOFAZIMINE COMPOSITION AND METHOD FOR THE TREATMENT OR PROPHYLAXIS OF VIRAL INFECTIONS

9. The inhalable pharmaceutical composition of claims 1-7 for use in the treatment of SARS-CoV-2 pulmonary viral infection.

patents.justia.com/patent/20230248722#claims



Paper on Clofazimine and SARS-CoV2 published in Nature:
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

www.nature.com/articles/s41586-021-03431-4#:~:text=Overall%2C%20clofazimine%20exhibited%20broad%2Dspectrum,coronaviruses%20in%20human%20cellular%20models.

[sayhey24]

This is interesting. My first reaction is yesterday was the 4th anniversary of the national Covid emergency which was declared on March 13, 2020. Back then Operation Warp Speed provided all kinds of funding and rule exceptions to get such a treatment to market.

It seems the patent was filed on Apr. 30, 2021. Is that correct? I guess the next obvious question would be for Mike as to why this was not funded under Operation Warp Speed and moved to market during the rule exceptions.

Did we miss the market on this as we currently are with Saxenda DPI? BTW Oprah has a special on next Monday 3/18 on Ozempic and her use which got her kicked off the Weight Watchers board. Maybe she would like to be a partner on Saxenda DPI?

[hellodolly]

Mar 14, 2024 6:10:18 GMT -5 sayhey24 said:

This is interesting. My first reaction is yesterday was the 4th anniversary of the national Covid emergency which was declared on March 13, 2020. Back then Operation Warp Speed provided all kinds of funding and rule exceptions to get such a treatment to market.

It seems the patent was filed on Apr. 30, 2021. Is that correct? I guess the next obvious question would be for Mike as to why this was not funded under Operation Warp Speed and moved to market during the rule exceptions.

Did we miss the market on this as we currently are with Saxenda DPI? BTW Oprah has a special on next Monday 3/18 on Ozempic and her use which got her kicked off the Weight Watchers board. Maybe she would like to be a partner on Saxenda DPI?

I wouldn't think MNKD financials were healthy enough at the time to move this into trials. 

I've been following the vaccine space for decades and mRNA technology wasn't going to be supplanted by any new developmental stage drugs, period.  Look around.  Considering the government spent billions on mRNA tech years before SARS-Cov-2, I'm thankful MNKD didn't take that route.  mRNA technology is the NIH darling technology and be damned if anyone was going to disrupt their goals to push this into global sized PHIII trial. 

Next, OWS was a dog and pony show to placate the public and calm the masses and BARDA was determined to make sure the mRNA players got much of the funding to offset the expenditures for the cold chain storage, transportation and distribution issues. Essentially, the long of the short is mRNA technology was already decided upon as the winner.  

MNKD would've been rejected at every turn, like most of the other dozens of vaccine makers who spent billions in combined research chasing a pipe dream, only to come up empty for the reasons stated above. 

[sayhey24]

Mar 14, 2024 8:53:37 GMT -5 hellodolly said:

Mar 14, 2024 6:10:18 GMT -5 sayhey24 said:

This is interesting. My first reaction is yesterday was the 4th anniversary of the national Covid emergency which was declared on March 13, 2020. Back then Operation Warp Speed provided all kinds of funding and rule exceptions to get such a treatment to market.

It seems the patent was filed on Apr. 30, 2021. Is that correct? I guess the next obvious question would be for Mike as to why this was not funded under Operation Warp Speed and moved to market during the rule exceptions.

Did we miss the market on this as we currently are with Saxenda DPI? BTW Oprah has a special on next Monday 3/18 on Ozempic and her use which got her kicked off the Weight Watchers board. Maybe she would like to be a partner on Saxenda DPI?

I wouldn't think MNKD financials were healthy enough at the time to move this into trials. 

I've been following the vaccine space for decades and mRNA technology wasn't going to be supplanted by any new developmental stage drugs, period.  Look around.  Considering the government spent billions on mRNA tech years before SARS-Cov-2, I'm thankful MNKD didn't take that route.  mRNA technology is the NIH darling technology and be damned if anyone was going to disrupt their goals to push this into global sized PHIII trial. 

Next, OWS was a dog and pony show to placate the public and calm the masses and BARDA was determined to make sure the mRNA players got much of the funding to offset the expenditures for the cold chain storage, transportation and distribution issues. Essentially, the long of the short is mRNA technology was already decided upon as the winner.  

MNKD would've been rejected at every turn, like most of the other dozens of vaccine makers who spent billions in combined research chasing a pipe dream, only to come up empty for the reasons stated above. 

Don't you think someone with some money was willing to partner?  Don't you think Uncle Sam was providing significant funding for Operation Warp Speed.

I can tell you first hand OWS was more than a D&PS.  In fact several of my family members worked near 7 days a week for a year+.  The sad thing is all three of the projects they worked on failed but they got funding.

Here is an article about Emergent.  They got $628M on a no-bid contract and their work failed.  I bet for $100M we could have loaded on Technosphere, Clofazimine and made ClofoCovid DPI.  What I do remember Mike saying during Covid was they looked at it and saw it more of a distraction.  Yet, they filed this patent and now we have MNKD-101 which we are 100% funding.
www.bloomberg.com/news/features/2020-10-29/inside-operation-warp-speed-s-18-billion-sprint-for-a-vaccine

Even if ClofoCovid DPI got rejected it sure seems it would have paid for most of the MNKD-101 development and moved its development along a lot faster.

At least now we know MNKD was doing something during Covid and even filed a patent.  The good news is SARs is not going away so maybe we can still rebrand MNKD-101 for SARs based viruses.

As far as the mRNA,  I am not a big fan.  I have a lot of friends getting all kinds of cancers.  Is it related IDK but its weird.  I also know I got 1 booster and then after that got myocarditis.  I have no doubt it was from that "vaccine" which is not really a "vaccine".  Heck, everyone I know who got that "vaccine" got Covid and usually multiple times.  After doing some research on it, I would never ever take another mRNA based injection.  

I found this an interesting "chat" on mRNA.  Is this guy right?  Probably at least partially I would say
tuckercarlson.com/the-tucker-carlson-encounter-bret-weinstein/

[RainbowUnicorn]

Bret Winstein is a sharp guy. Getting railroaded out of Evergreen College, during the BLM disaster, opened him up.

www.bretweinstein.net/

[porkini]

?

[peppy]

Mar 14, 2024 5:41:39 GMT -5 mango said:

In one of the slides Mike presented on Clofazimine it mentions expanding into other indications within the Infectious Disease Category.

I present a patent by MannKind indicated for the treatment of SARS-CoV2 using Clofazimine:
CLOFAZIMINE COMPOSITION AND METHOD FOR THE TREATMENT OR PROPHYLAXIS OF VIRAL INFECTIONS

9. The inhalable pharmaceutical composition of claims 1-7 for use in the treatment of SARS-CoV-2 pulmonary viral infection.

patents.justia.com/patent/20230248722#claims



Paper on Clofazimine and SARS-CoV2 published in Nature:
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

www.nature.com/articles/s41586-021-03431-4#:~:text=Overall%2C%20clofazimine%20exhibited%20broad%2Dspectrum,coronaviruses%20in%20human%20cellular%20models.

Last time I checked which was two weeks ago, @200 people a week are dying of Corona Virus SARS2 a week in the USA.

  

[sayhey24]

Peppy - The CDC guidance says that officials should report deaths in which the patient tested positive for COVID-19 — or, if a test isn’t available, “if the circumstances are compelling within a reasonable degree of certainty.” It further indicates that if a “definite diagnosis of COVID–19 cannot be made, but it is suspected or likely (e.g., the circumstances are compelling within a reasonable degree of certainty), it is acceptable to report COVID-19 on a death certificate as ‘probable’ or ‘presumed.'”

Hospitals get an extra $13,000 if they diagnose a death as COVID-19 and an additional $39,000 if they use a ventilator.

Dr Dan wants us to get another Covid shot every 4 months. Thanks but no thanks. My first case of Covid was weird for a couple of days. After I got the "vaccine" I got it again and it was a lot worse than my first case and then after my one and only booster I got it again but not as bad as the second bout. However after my first and last booster I got myocarditis and that lasted 6+ months. Was it from the mRNA shot, IDK but not worth the risk.

[sportsrancho]

Mar 15, 2024 12:42:00 GMT -5 sayhey24 said:

Peppy - The CDC guidance says that officials should report deaths in which the patient tested positive for COVID-19 — or, if a test isn’t available, “if the circumstances are compelling within a reasonable degree of certainty.” It further indicates that if a “definite diagnosis of COVID–19 cannot be made, but it is suspected or likely (e.g., the circumstances are compelling within a reasonable degree of certainty), it is acceptable to report COVID-19 on a death certificate as ‘probable’ or ‘presumed.'”

Hospitals get an extra $13,000 if they diagnose a death as COVID-19 and an additional $39,000 if they use a ventilator.

Dr Dan wants us to get another Covid shot every 4 months. Thanks but no thanks. My first case of Covid was weird for a couple of days. After I got the "vaccine" I got it again and it was a lot worse than my first case and then after my one and only booster I got it again but not as bad as the second bout. However after my first and last booster I got myocarditis and that lasted 6+ months. Was it from the mRNA shot, IDK but not worth the risk.

I’ve never been vaccinated. I don’t do them… especially those vaccines!

[mytakeonit]

Living in Hawaii and seeing all those tourist coming in with Covid ... especially after flying in an enclosed airplane for several hours ... then you see Covid numbers climbing fast in Hawaii ... you realize that we need that Covid shot.

I took the initial Covid shot and then later received the booster. I never caught Covid ... fingers crossed.

[skiidog]

I have never been vaccinated and never caught COVID. MRNA vaccines were definitely Fauci’s baby. He has been funding them for years. Until their COVID vaccine was approved, Moderna never passed a phase II clinical trial. In fact their ZIKA trial was an unmitigated disaster.

[mytakeonit]

My wife and I took the Pfizer vaccine. We didn't have any side effects.

[Thundersnow]

Mar 15, 2024 14:07:23 GMT -5 mytakeonit said:

Living in Hawaii and seeing all those tourist coming in with Covid ... especially after flying in an enclosed airplane for several hours ... then you see Covid numbers climbing fast in Hawaii ... you realize that we need that Covid shot.

I took the initial Covid shot and then later received the booster. I never caught Covid ... fingers crossed.

Sounds familiar when Captain Cook visited Hawaii in 1778 and brought DISEASE to the Native Hawaiians.  Back then it was on SHIPS. 

History repeats itself!

[mytakeonit]

Yeah ... I think we killed that guy also. But, that's how it goes ...

[mpg54]

Mar 14, 2024 17:34:59 GMT -5 sayhey24 said:

Mar 14, 2024 8:53:37 GMT -5 hellodolly said:

I wouldn't think MNKD financials were healthy enough at the time to move this into trials. 

I've been following the vaccine space for decades and mRNA technology wasn't going to be supplanted by any new developmental stage drugs, period.  Look around.  Considering the government spent billions on mRNA tech years before SARS-Cov-2, I'm thankful MNKD didn't take that route.  mRNA technology is the NIH darling technology and be damned if anyone was going to disrupt their goals to push this into global sized PHIII trial. 

Next, OWS was a dog and pony show to placate the public and calm the masses and BARDA was determined to make sure the mRNA players got much of the funding to offset the expenditures for the cold chain storage, transportation and distribution issues. Essentially, the long of the short is mRNA technology was already decided upon as the winner.  

MNKD would've been rejected at every turn, like most of the other dozens of vaccine makers who spent billions in combined research chasing a pipe dream, only to come up empty for the reasons stated above. 

Don't you think someone with some money was willing to partner?  Don't you think Uncle Sam was providing significant funding for Operation Warp Speed.

I can tell you first hand OWS was more than a D&PS.  In fact several of my family members worked near 7 days a week for a year+.  The sad thing is all three of the projects they worked on failed but they got funding.

Here is an article about Emergent.  They got $628M on a no-bid contract and their work failed.  I bet for $100M we could have loaded on Technosphere, Clofazimine and made ClofoCovid DPI.  What I do remember Mike saying during Covid was they looked at it and saw it more of a distraction.  Yet, they filed this patent and now we have MNKD-101 which we are 100% funding.
www.bloomberg.com/news/features/2020-10-29/inside-operation-warp-speed-s-18-billion-sprint-for-a-vaccine

Even if ClofoCovid DPI got rejected it sure seems it would have paid for most of the MNKD-101 development and moved its development along a lot faster.

At least now we know MNKD was doing something during Covid and even filed a patent.  The good news is SARs is not going away so maybe we can still rebrand MNKD-101 for SARs based viruses.

As far as the mRNA,  I am not a big fan.  I have a lot of friends getting all kinds of cancers.  Is it related IDK but its weird.  I also know I got 1 booster and then after that got myocarditis.  I have no doubt it was from that "vaccine" which is not really a "vaccine".  Heck, everyone I know who got that "vaccine" got Covid and usually multiple times.  After doing some research on it, I would never ever take another mRNA based injection.  

I found this an interesting "chat" on mRNA.  Is this guy right?  Probably at least partially I would say
tuckercarlson.com/the-tucker-carlson-encounter-bret-weinstein/

I’ve got 5 or 6 jabs, most recently last October. Never had COVID once. I swear by it, as I have noticed i haven’t been sick in a few years. I can’t remember the last time a had the flu or for that matter a cold. I don’t wear masks, haven’t since early 2021. I feel healthy as a horse, I don’t take any medication for anything. My feeling is this worry about vaccines is complete nonsense, if they recommend another jab I’ll take one…