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Post by liane on Oct 17, 2014 4:21:30 GMT -5
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Post by cybergym66 on Oct 17, 2014 4:30:50 GMT -5
Nice Find!!! I've been wondering about all the different applications using Technosphere and would never have thought about using it to increase bone mineral density in patients with osteopenic disorders. That's a BIG market! |
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alexer
Lab Rat
Posts: 49 
Sentiment: Long
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Post by alexer on Oct 17, 2014 7:59:59 GMT -5
This is the best part:
"No differences were seen between pulmonary and subcutaneous application with regard to the PTH(1 - 84), calcitonin and calcium concentrations. In conclusion, pulmonary application of Technosphere/PTH(1 - 34) appears to be an effective and thus attractive candidate for PTH substitution therapy in osteoporosis and other conditions leading to a decrease in bone mineral density."
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Post by rak5555 on Oct 17, 2014 8:30:34 GMT -5
Is subcutaneous injection currently approved for treatment? If yes, who are the players (potential partners)? Wouldn't it take years to get this through the FDA gauntlet? How would development be funded? Where would this product be manufactured (I wonder if deal w/ SNY prevents production at Danbury)?
This kind of news will be more valuable once we have a comprehensive technosphere business plan to relate to.
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Post by esstan2001 on Oct 17, 2014 9:49:23 GMT -5
Eli Lilly has Forteo (an expensive, daily injectable (e-coli derived) recombinant PTH for bone density and pagetts disease. It works to increase bone formation instead of halting resorption as all the bisphosphonates like Fosomax, Actonel, Boniva, etc. do. Unigene (Bkpt- IP and assets now in a new company beginning with 'E' can't remember) had a PII next gen enteric coated oral PTH that looked good, but partner GSK backed out, variable bioavailability was always suspected but not clear that was an issue any more.
This market is the osteoporosis, osteo-athritis space. BIG.
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Post by dubylvs on Oct 17, 2014 11:53:40 GMT -5
Enteris Biopharma is the E name you were looking for.. Their (niche) was getting injectibles into pill form i believe.
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Post by notamnkdmillionaire on Oct 17, 2014 16:18:28 GMT -5
The study is from 2003. Doesn't look like it went anywhere. And we have no idea what MNKD is working on now. The question is, when will we find out?
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Post by suebeeee1 on Oct 17, 2014 16:32:09 GMT -5
The study is from 2003. Doesn't look like it went anywhere. And we have no idea what MNKD is working on now. The question is, when will we find out?  Now THAT is depressing! |
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Post by liane on Oct 17, 2014 16:44:49 GMT -5
Oops! Didn't notice the date on the article when I posted it in my pre-coffee daze early this morning. Still, it is significant, and I foresee many more protein based drugs finding a home on the Technosphere platform
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Now THAT is depressing!