A1C, Afrezza, My story

[piccolopete]

Misleading to believe Afrezza would bring down A1c levels during the trials. A1c (my understanding) is a more of a long term marker and an increase in basal would be required (in most cases) to achieve meaningful reductions over time. However, with Afrezza usage, physicians would be able to increase basal without as much fear of hypoglycemic events as the tail of the ultra rapid acting insulin would be practically non-existent. The trials were not structured in this manner. It would have been phenomenal if material A1C reductions occurred.

So, physicians are going to be in a better position to tweak dosages on the basal side of the equation to achieve A1C reductions with concurrent usage of Afrezza as compared to currently available shorter acting insulin therapies.

And then, as has been pointed out to me, there's the population of pre-diabetics and new diabetics that may benefit greatly from aggressive early insulin treatment (Afrezza). I happen to be on the cusp of being included in this population - 57 yr. old, 5'10, 152 lbs, formerly very athletic, vegetarian, heavy genetics for diabetes on father's side, 106 fasting glucose past 2 yrs, high cholesterol, getting blood drawn tomorrow for another fasting glucose test, watched my father, his brother and mother die of complications for diabetes....................

Criminey, I've turned into a MNKD bull. 

[rak5555]

Better late than never. Welcome to the cult.

SO, if Afrezza were already approved and tomorrow your doc suggested you begin Metformin or mealtime Afrezza, what would you choose? Or, if tomorrow your doc wanted to start you on insulin injections would you beg her to let you try Afrezza first?

[engineer4life]

Your mother has diabetes and died of diabetic complications, too? You came from a tough luck family genetically. Mine is only from the father side.