Demand

[ezrasfund]

Much of the talk on CF is of the classic "I am not a crook/troll" variety.

[jpg]

Feb 4, 2015 23:51:59 GMT -5 ezrasfund said:

Much of the talk on CF is of the classic "I am not a crook/troll" variety.

Hopefully someone picked up on the secret code: Pro and Board?  I think someone is trying to send us a message... Wonder who?

[lynn]

JPG ,
Maybe it's OPC ? ,)


Not trying to get off topic but that was first thought that popped into my head when I read it

[gamblerjag]

Santa Clara, CA news..  start video at 1:40..  yes this is getting out there!

www.hometownstation.com/santa-clarita-news/business/mannkind-corp-afrezza-insulin-inhalant-now-for-sale-120847

[BlueCat]

Feb 4, 2015 22:44:54 GMT -5 jpg said:

Check out Cafe pharma now! It's being overrun by a secret coded message...

Hah!  I think the secret coded message from shorts ought to be in emoticon morse-code:

              

[pmikeks]

Is that why we have so many new posters on this board? Looking for news and some truth from those who have done DD not just blah-blah BS. Some of the posts are comical saying its bad but not having a clue why. Could say they are talking out their @ss cuz that's where their heads at.

[mnholdem]

 They're arriving in droves because they've been repeatedly told this is where the intelligent discussions happen.

I'll try to locate and link some examples... it may take awhile.

[mannmade]

Feb 3, 2015 21:00:11 GMT -5 mannmade said:

Here's a thought... So what if Afrezza does become the first line of insulin therapy for T-2's. What does it do to Basal Insulin sales? And does Sanofi even care as they would then have a stranglehold on the T2 population (with no competition to Afrezza near market) if as some are suggesting you may not even need Basil to treat many T2's if they are using Afrezza. Sanofi may be a whole lot smarter than they look... And right now they look pretty smart to me... Just a thought...

I rest my case... (taken from 02.05.15 SA Article on the synopsis of the Sanofi ER call for same date, see posted article for complete context and reference)

But, in fact, though this is not currently on the Afrezza label, there is reason to believe that many patients with Type 2 diabetes might be able to use Afrezza instead of basal insulin. Substantiating this is the fact that Afrezza poster boy, Sam Finta, who tweets as afrezzauser, and who is an insulin-dependent Type 1, demonstrated, using Continual Glucose Monitor System screen shots, that he could attain near normal blood sugars for two days using no Lantus at all, just Afrezza. Since blood sugars in Type 2 diabetes are much easier to control than those in Sam's Type 1 diabetes, it is very possible that the market for Afrezza in "insulin naive" patients-those who have taken no insulin at all, is huge. Possibly much larger than the market for Lantus or any basal insulin.

Read more: mnkd.proboards.com/thread/970/articles-media-spots-on-mnkd?page=55#ixzz3Qtxaa6RA

[brentie]

But, in fact, though this is not currently on the Afrezza label, there is reason to believe that many patients with Type 2 diabetes might be able to use Afrezza instead of basal insulin.

That sounds pretty magical. Does this work for Type 2s only, or is it an option for Type 1s now taking basal and bolus insulin?


Al:


Both could use it. Afresa is for prandial control — mealtime only - not basal doses. For about 70% of Type 2s, all you'll need is a regular set dose of Afresa. This will work for everyone except the "late-stage" Type 2s, who will need to take basal insulin as well.



It's different for Type 1's because there's a very big therapeutic window for them; their insulin needs are so differing. They can use Afresa to cover meals, yes, but they'll still have the issue that if they dose and don't eat anything, they'll get hypo, and if they eat a large meal, they'll need a larger dose.



The advantage for all patients is that they won't have to do carb counting or anything, because Afresa does not have to be so precisely matched to food intake.


Aren't most Type 2s currently treated with a basal insulin only, instead of mealtime dosing?



Al:

Yes, but that's the wrong way around. The correct therapy should be a good prandial insulin and not long-term insulin — Afresa in particular because it turns off glucose production and delivery from the liver. Our latest trials of 600 patients are showing even more significant benefits from the product than our original trials; the most recent trial appears to show that this should replace frontline treatment for all Type 2 patients.

www.healthline.com/diabetesmine/the-truth-about-afresa-inhalable-insulin-a-chat-with-al-mann#2