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Post by otherottawaguy on Feb 27, 2015 11:51:12 GMT -5
www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000588/WC500054704.pdf
Special Populations
Smoking
Smoking greatly increases the rate and extent of absorption of inhaled human insulin (Cmax about 3 to
5 times and AUC about 2 to 3 times higher) and therefore could increase the risk of hypoglycaemia
(see sections 4.3 and 4.5).
When EXUBERA was administered to healthy volunteers following 2-hours of passive exposure to
cigarette smoke in a controlled experimental setting, insulin AUC and Cmax were reduced by
approximately 17 and 30%, respectively (see section 4.5).
The above is from an document filed with the EMA and is referencing findings with Exubera.
Does have the potential to mean that smokers might require a smaller dosage of Afrezza to get the same effect as a non-smoker?
OOG |
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Post by jpg on Feb 27, 2015 12:31:53 GMT -5
www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000588/WC500054704.pdf
Special Populations
Smoking
Smoking greatly increases the rate and extent of absorption of inhaled human insulin (Cmax about 3 to
5 times and AUC about 2 to 3 times higher) and therefore could increase the risk of hypoglycaemia
(see sections 4.3 and 4.5).
When EXUBERA was administered to healthy volunteers following 2-hours of passive exposure to
cigarette smoke in a controlled experimental setting, insulin AUC and Cmax were reduced by
approximately 17 and 30%, respectively (see section 4.5).
The above is from an document filed with the EMA and is referencing findings with Exubera.
Does have the potential to mean that smokers might require a smaller dosage of Afrezza to get the same effect as a non-smoker?
OOG I would say smokers shouldn't and hopefully will not use Afrezza but if they do it shouldn't make a big difference to any individual patient ad they are their own control to a measurable goal (BG) so even if they need less (or more) that would auto adjust. |
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Post by daduke38 on Mar 1, 2015 16:00:11 GMT -5
Not to defend smoking, but if 30+ years of knowing that Smoking is bad for you, why does the FDA still lets them be sold? Now if you aren't worried about smoking, why would adding Afrezza on top of it be so concerning? Smoking is a choice, not a wise one, but a choice. I think keeping Smokers from Afrezza is somewhat hypicritical of the FDA.
I can understand to a degree not allowing COPD patients, but maybe not.
For the life of me, other than the big money tobacco lobbyists Cigarettes should not be sold.
I quit years ago, so I mean no offense to any on this board that may smoke, but hopefully you get my point.
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Post by kc on Mar 1, 2015 17:58:46 GMT -5
Phillip Morris international and Altria are two great cash cow stocks as smokers just continue to buy their products in the US and worldwide. Love their dividends.
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Post by xoxoxoxo on Mar 1, 2015 19:26:33 GMT -5
The only problem with letting smokers use Afrezza is when they end up getting cancer, the Afrezza will be blamed (by the shorts) instead of the cigarettes.
We're better off getting the data that shows Afrezza doesn't cause lung cancer vs the extra sales to smokers for the next year or two.
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