Post by liane on Sept 12, 2013 7:23:48 GMT -5
Nice article in Journal Diabetes Sci Technology from last year:
www.jdst.org/July2012/PDF/Articles/VOL-6-4-SYM5-BOSS.pdf
"Thus the use of an initial prandial and potentially an
added supplemental postprandial dose of TI may result
in an improvement in both early and late PPG control
without an increase in hypoglycemia. Predicting in
advance the insulin requirement for a meal is difficult,
as the PPG response is influenced by multiple factors
(e.g., meal composition, variability in gastric emptying,
duration of the meal). Being able to react to the actual
glycemic response to a meal may provide patients with
additional freedom in their diet. The administration
by inhalation, using a simple, breath-operated device
may overcome the difficulties of introducing
multiple prandial doses.
Summary
Currently available, subcutaneously delivered RAAs have
PK/PD profiles that are still poorly synchronized with
PPG excursions. Ultra-rapid-acting insulins, such as inhaled
TI, result in better control of early PPG with less weight
gain and less frequent hypoglycemia, but control of late
PPG remains suboptimal. Preliminary evidence suggests
that, when needed, a second dose of ultra-rapid-acting
insulin may result in more prolonged control of late PPG
without further adverse effects. Future study is needed
to explore the utility of this strategy."
The whole issue of this journal is devoted to a symposium on ultra-fast insulins:
jdst.org/July2012/
www.jdst.org/July2012/PDF/Articles/VOL-6-4-SYM5-BOSS.pdf
"Thus the use of an initial prandial and potentially an
added supplemental postprandial dose of TI may result
in an improvement in both early and late PPG control
without an increase in hypoglycemia. Predicting in
advance the insulin requirement for a meal is difficult,
as the PPG response is influenced by multiple factors
(e.g., meal composition, variability in gastric emptying,
duration of the meal). Being able to react to the actual
glycemic response to a meal may provide patients with
additional freedom in their diet. The administration
by inhalation, using a simple, breath-operated device
may overcome the difficulties of introducing
multiple prandial doses.
Summary
Currently available, subcutaneously delivered RAAs have
PK/PD profiles that are still poorly synchronized with
PPG excursions. Ultra-rapid-acting insulins, such as inhaled
TI, result in better control of early PPG with less weight
gain and less frequent hypoglycemia, but control of late
PPG remains suboptimal. Preliminary evidence suggests
that, when needed, a second dose of ultra-rapid-acting
insulin may result in more prolonged control of late PPG
without further adverse effects. Future study is needed
to explore the utility of this strategy."
The whole issue of this journal is devoted to a symposium on ultra-fast insulins:
jdst.org/July2012/
