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Post by gomnkd on May 3, 2015 15:00:25 GMT -5
Through friends and family, I checked with three endos all in Atlanta. 1) Checked two months back, this endo hasn't heard of Afrezza, talked about an inhaled insulin that flopped. Worried about costs and patient affordability 2) Dr Darwin Brown has started prescribing Afrezza since last 2 weeks 3) Another endo also has started prescribing recently and has this to say "it is a good bolus insulin, easy to use, would recommend if normal lungs" I think we are slowly but surely seeing uptake. This is a pattern that is going to be repeated across this country. I also think that prescriptions are not concentrated with just a few endos. This would mean that those endos who are prescribing to 1 or 2 pts will ramp it up once they see good results. So a journey of 1000 miles begins with one step. ---------------------------------------------------------------------------------------------------------------------------------------------------------- Someone asked about RAA uptake in the other thread. I did some research a week back as introduction of Humalog mirrors Afrezza in some ways. When Humalog was introduced, Humulin and others dominated the market. Humalog uptake is stunning. Humulin peaked later and then slowly lost mkt share. Attachment DeletedThe one is green is what would be Afrezza sales if we mimicked Humalog (I doubled to account for increased diabetic pt count). Again not considering pre-diabetic, increased dosage etc. It does provide a benchmark. Humalog sales are from SEC filings.
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Post by fpants on May 3, 2015 17:16:50 GMT -5
Thanks for the RAA uptake info gomnkd. I was the one asking. The "superiority label" is not essential then.
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Post by gomnkd on May 3, 2015 19:13:05 GMT -5
I like this comparison because Al Mann mentioned that when RAA were introduced it was viewed as offering no advantage to Humulin in terms of A1C, but only the convenience of timing.
I just cant believe that patients have waited ~20 years to get some innovation in prandial insulin. Looks like the pace of change is very slow.
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Post by jpg on May 3, 2015 22:23:12 GMT -5
At the same time that the speed of innovation is very slow once a new standard is achieved than it takes a while to displace it. This is what Afrezza is doing. The lack of superiority does not need to go away but a label with anything superior on it would be a big deal.
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Post by Chris-C on May 4, 2015 18:18:44 GMT -5
I agree but the label is now less important for creating consumer demand. Old social network rules no longer apply. See work by Nicholas Christakis at Yale... Www.nicholaschristakis.netHis work shows clearly that indirect social connections also matter greatly...and have surprising influence. Chris
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Post by compound26 on May 4, 2015 18:38:15 GMT -5
A superiority label will help with EU (and other counties) approval and launch. Even after approval by EU, some European countries have gateway institutions/authorities that do benefit vs cost analysis before recommending drugs to doctors.
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