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Post by savzak on Jun 4, 2015 20:15:12 GMT -5
In January of 2014, Spiro and I met Al Mann and Andrea Leona Bay at a drug delivery conference . Al was the key note speaker and Leona Bay gave a presentation on this very topic, Technoshpere inhalation for Migraine pain. They had just come from Torrey Pines the day before. To say they were excited was an understatement. They were bold enough to say that it would be bigger than Afrezza This may still be years away, but the future looks bright.
I still never understood how Torrey Pines was able to get the mice to inhale, but when I posted this last year someone actually sent the link to how it was done. Forget the inhaling part...how did the mice let the researchers know when they had a migraine? This is a true story. My secretary emailed me this morning at about 6:00 to tell me she had a migraine and would not be coming in to work. She did not have the benefit of an immediate Technosphere treatment and so, her prediction that she would not be at work today proved true. She felt bad all day but worse than that, she was completely unproductive. True story. |
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Post by bradleysbest on Jun 4, 2015 20:25:52 GMT -5
I'm surprised more people suffer from migraines than diabetes! Who knew....
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Post by corpplanner on Jun 4, 2015 20:30:53 GMT -5
There are several types of migraines and my guess is that they might be targeting one particular type to start. Orphan indication anyone?
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Post by Deleted on Jun 4, 2015 20:38:59 GMT -5
There are several types of migraines and my guess is that they might be targeting one particular type to start. Orphan indication anyone? Al mentioned in a video that his wife suffers from migraines. I believe is was one of the recent (not this years) annual shareholder meetings and I vividly remember him saying "imagine inhaling pain meds that start working on migraine pain in a couple of minutes" so perhaps this is near and dear to his heart. Is there really an effective therapy that gets rid of migraine pain in a few minutes, or how long do current therapies take and do they get rid of most of the pain? |
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Post by brentie on Jun 4, 2015 20:49:32 GMT -5
In January of 2014, Spiro and I met Al Mann and Andrea Leona Bay at a drug delivery conference . Al was the key note speaker and Leona Bay gave a presentation on this very topic, Technoshpere inhalation for Migraine pain. They had just come from Torrey Pines the day before. To say they were excited was an understatement. They were bold enough to say that it would be bigger than Afrezza This may still be years away, but the future looks bright. I still never understood how Torrey Pines was able to get the mice to inhale, but when I posted this last year someone actually sent the link to how it was done.
Ashiwi, of course that would be me.  mnkd.proboards.com/post/6836 |
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Post by Deleted on Jun 4, 2015 20:56:43 GMT -5
I wrote a long thing on this somewhere on Proboard a while back. If this is what I was hoping it is this is a very big deal. The peptide in question would make addiction impossible or highly difficult and theoretically be a major shift in how we treat pain. This is a long shot that I though was dead. This latest info seems to hint that the peptide in question is still in play? On a side note why is this being discussed in resources? If I understand this correctly this is a big deal. I say this cautiously because when I read stuff on my phone I tend to get a very partial understanding of what I read and don't want to repeat past mistakes! Can you dig it up or at least give your thoughts on it? Same with the other docs on the board. |
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Post by ashiwi on Jun 4, 2015 21:26:17 GMT -5
Thanks Brentie. Not sure how in the world you found that last year.
Pretty obscure stuff!
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Post by mnholdem on Jun 4, 2015 21:34:36 GMT -5
I believe that Torrey Pines had signed an agreement with Cara Pharmaceuticals to continue development of this opiate a few years ago after MannKind suspended pipeline activity to focus on getting Afrezza approved. Of course, Torrey Pines might still retain joint ownership on the patent. The biggest benefit of the inhaled opiate is that, unlike its oral counterpart, this pain med is completely non-addictive. I recall Al talking about this some time ago and he seemed really, really excited.
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Post by mannmade on Jun 4, 2015 22:13:09 GMT -5
I believe that Torrey Pines had signed an agreement with Cara Pharmaceuticals to continue development of this opiate a few years ago after MannKind suspended pipeline activity to focus on getting Afrezza approved. Of course, Torrey Pines might still retain joint ownership on the patent. The biggest benefit of the inhaled opiate is that, unlike its oral counterpart, this pain med is completely non-addictive. I recall Al talking about this some time ago and he seemed really, really excited. I also believe in addition to being non-addictive, that they said you cannot overdose on it. (Do not recall where I saw or heard that but it is my recollection) |
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Post by lynn on Jun 4, 2015 22:38:25 GMT -5
I wrote a long thing on this somewhere on Proboard a while back. If this is what I was hoping it is this is a very big deal. The peptide in question would make addiction impossible or highly difficult and theoretically be a major shift in how we treat pain. This is a long shot that I though was dead. This latest info seems to hint that the peptide in question is still in play? On a side note why is this being discussed in resources? If I understand this correctly this is a big deal. I say this cautiously because when I read stuff on my phone I tend to get a very partial understanding of what I read and don't want to repeat past mistakes! Can you dig it up or at least give your thoughts on it? Same with the other docs on the board. JPG , This was your reply to a discussion we had a while back about pain . I'm on my phone so not sure how to attach the link , but many of us had a lot to say about it . JPG 's post is pasted below ( I'm not sure if this is the one you were referring to ) Generic ibuprofen can probably be found for about 10-20 cents a pill if you buy in bulk and 50 cents- 1$ a pill for the branded stuff in small quantities at corner stores. That is a factor of at least 5 and people (including me) regularly buy it quickly if we have pain. We don't find the nearest low cost supplier. Convenience and speed matter. How much more would people pay to get almost instant relief? I don't know but I have no doubt there is a market. How big a market? Don't know but do know it is a function of marketing and price. Like baba says some pay over 2 times the price of regular coffee for daily morning coffee (and 3 times the 'regular' price for my computing needs because they are Apple). Yes you can make counter arguments and have freedom to think but at the same time posters have the right to consider your premises as flawed as you consider theirs flawed... As for your suffering from asthma and your wife getting migraines: what does that have to do with anything? I've seen patients code from asthma because they couldn't get relief fast enough (this being said I don't necessarily see the benefit of technosphere in asthma unless it's a different class of medication then beta agonists or inhaled steroids). Patients regularly go to the ER for a migraine. You don't think these patients wouldn't like a simple low cost solution? Have you seen the average price of a US ER visit recently? I think plenty of people would pay 15$ to avoid spending 1 hour in the ER and I am certain a bunch of insurers would feel the same. All of this is relatively standard knowledge in health care marketing and marketing at large I thought? Read more: mnkd.proboards.com/thread/2298/question-technosphere?page=1#ixzz3c9gPy99H |
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Post by jpg on Jun 4, 2015 22:51:32 GMT -5
Can you dig it up or at least give your thoughts on it? Same with the other docs on the board. JPG , This was your reply to a discussion we had a while back about pain . I'm on my phone so not sure how to attach the link , but many of us had a lot to say about it . JPG 's post is pasted below ( I'm not sure if this is the one you were referring to ) Generic ibuprofen can probably be found for about 10-20 cents a pill if you buy in bulk and 50 cents- 1$ a pill for the branded stuff in small quantities at corner stores. That is a factor of at least 5 and people (including me) regularly buy it quickly if we have pain. We don't find the nearest low cost supplier. Convenience and speed matter. How much more would people pay to get almost instant relief? I don't know but I have no doubt there is a market. How big a market? Don't know but do know it is a function of marketing and price. Like baba says some pay over 2 times the price of regular coffee for daily morning coffee (and 3 times the 'regular' price for my computing needs because they are Apple). Yes you can make counter arguments and have freedom to think but at the same time posters have the right to consider your premises as flawed as you consider theirs flawed... As for your suffering from asthma and your wife getting migraines: what does that have to do with anything? I've seen patients code from asthma because they couldn't get relief fast enough (this being said I don't necessarily see the benefit of technosphere in asthma unless it's a different class of medication then beta agonists or inhaled steroids). Patients regularly go to the ER for a migraine. You don't think these patients wouldn't like a simple low cost solution? Have you seen the average price of a US ER visit recently? I think plenty of people would pay 15$ to avoid spending 1 hour in the ER and I am certain a bunch of insurers would feel the same. All of this is relatively standard knowledge in health care marketing and marketing at large I thought? Read more: mnkd.proboards.com/thread/2298/question-technosphere?page=1#ixzz3c9gPy99HHi Lynn, Thanks for finding that. What I was referring to was much older and was a relatively detailed (as much as can be done with the limited information at hand) analysis of the pain peptide. In a few words a peptide that targets certain peripheral receptors and does not cross the blood brain barrier could theoretically be addiction free but at the same time be very effective for certain types of specific pain syndromes. Delivering it by inhalation would get a really quick level and saturate receptors almost instantly. The non central mechanism would also be overdose proof. As for centrally acting peptides I don't have enough information/ knowledge to make an educated guess as to how these could act and be both addiction free and overdose safe while also being highly effective. Inhaled 'traditional narcotics' like morphine, fentanyl etc. would be a nightmare from an overdose and addiction perspective (but would be highly effective!). Not going to happen. And after looking for the original post for a few minutes I gave up. The number of posts I have done here are 'impressive'... |
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Post by Deleted on Jun 5, 2015 0:07:42 GMT -5
The number of posts I have done here are 'impressive'... Agreed 1034 times. |
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Post by mnholdem on Jun 5, 2015 7:19:38 GMT -5
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Post by tripoley on Jun 5, 2015 8:19:29 GMT -5
In January of 2014, Spiro and I met Al Mann and Andrea Leona Bay at a drug delivery conference . Al was the key note speaker and Leona Bay gave a presentation on this very topic, Technoshpere inhalation for Migraine pain. They had just come from Torrey Pines the day before. To say they were excited was an understatement. They were bold enough to say that it would be bigger than Afrezza This may still be years away, but the future looks bright. I still never understood how Torrey Pines was able to get the mice to inhale, but when I posted this last year someone actually sent the link to how it was done. Scientists are very tricky when it comes to mice.  |
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Post by rak5555 on Jun 5, 2015 8:33:35 GMT -5
Non addictive and abuse proof? Those are 2 huge sales impediments.
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