|
Post by lakers on Jun 29, 2016 17:55:33 GMT -5
www.freshpatents.com/-dt20160623ptan20160175079.phpInsufflation apparatus and methods An insufflation apparatus and methods for using same are disclosed. The apparatus is equipped with an interactive system for administering reproducible intratracheal aerosols in a consistent automated manner. The insufflation system is useful, in particular for use with experimental animals, including mice and rats and also for treating small animals via the pulmonary route in veterinary medicinal practice. Examples of drugs for lung delivery include, vasodilators, surfactants, chemotherapeutic agents, or vaccines for flu, or other respiratory illnesses for the treatment of diseases, including, asthma, COPD, cystic fibrosis, and pulmonary infections. Pulmonary administration enables rapid treatment of these chronic and acute conditions. Drug formulations for treating pulmonary diseases such as asthma are available by several methods, including, using nebulizers such as treatment with PULMOZYME®, using metered-dose inhalers such as SYMBICORT®, and dry powder inhalers such as ADVAIR DISKUS®, PULMICORT FLEXHALER®. Other types of treatments, including biologics such as nucleotides drugs in genetic therapy have been delivered to the lungs, for example, for gene therapy of cystic fibrosis, where retroviral vectors expressing an effective adenosine deaminase are administered to the lungs. Currently, formulations for treating systemic disease using biologic products are available primarily through injectable compositions. Dry powder compositions for pulmonary inhalation and systemic delivery of insulin have been used, including EXUBERA®, and AFREZZA®.
|
|