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Post by Deleted on Dec 15, 2015 11:59:21 GMT -5
Great article once the portion of Jeremy starts. This author annoys me. He is such a hypocrite. The lung issues are a concern? Homeboy you eat like shit and drink a lot for a diabetic. Was this about a new treatment for diabetics or SNY dropping MNKD. Also great to hear he writes for a diabetes page but couldn't figure out how to use Afrezza correctly. I guess he could of asked Amy but then again she didnt know how to use either.... and he should be in a position to use/ figure out the tool to benefit him - for some one that portrays themselves as an advocate lol |
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Post by Deleted on Dec 15, 2015 11:59:57 GMT -5
I loved reading the comment that one purpose was designing a clinical trial... exactly what I expected. Did not at all like reading "So if you haven’t tried it, or the doctors haven't offered or discussed it with patients, time might be running out!" coming from someone that attended the SNY meeting. How could the meeting both be known to be about an upcoming clinical trial, and yet leave one of its medical professional attendees unclear whether Afrezza will continue to be on the market? Hopefully that comment is merely to spur more doctors and patients to give Afrezza a try... though I'm not sure I see the logic in it, as people may also rightly question whether it worth the effort (often onerous effort) to give it a try if Afrezza may go the way of Exubera. Great quotes from the participants. Why would SNY pull a drug with that sort of feedback? Why might time be running out? These guys have beefed in the past. I dont trust the author. You can find on twitter around October 2015 Afrezzauser afrezzauserNothing like paid diabetes advocates slamming #afrezza @mhoskins2179 @diabetesmine @amydbmine To date I have been paid 0!Can u say the same? RETWEETS 9 LIKES 43 edward alanVan LeRebeccajScott KetcherBenjamin AllerFredFranzoStephen ParsonsGeorgeBauer 10:13 AM - 6 Oct 2015 Reply Retweet Like More Amy Tenderich @amydbmine Oct 6 afrezzauser WHAT are you saying here, Sam? 0 retweets 0 likes Reply Retweet Like More View other replies p_code @p_codetwit Oct 6 @amydbmine afrezzauser Amy, there's a "translate from" option if somehow Sam's tweet wasn't in English. #ourd #dblog #type1 #t1d #hcsm #t2d 0 retweets 3 likes Reply Retweet Like 3 More am off @amoffvk Oct 6 afrezzauser @mhoskins2179 @diabetesmine @amydbmine isn't it obvious? It is for everyone else 0 retweets 0 likes Reply Retweet Like More jim hall @beeniecopter Oct 6 afrezzauser @mhoskins2179 @diabetesmine @amydbmine Stopped following those guys once she kissed AF. |
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Post by dreamboatcruise on Dec 15, 2015 12:10:39 GMT -5
"Users report...." Therein lies a problem. To really compare, you need some sort of well documented lifestyle/therapy history before and after starting afrezza. More importantly for afrezza, there needs to be solid clinical documentation to show insurance companies that patients in general are getting consistent improved results and that those results are in some fashion due to afrezza. This sort of documentation invariably requires a large and prolonged trial. I can't find anywhere that Sanofi has indicated whether they plan on any other trials other than those mandated by the FDA. MNKD has discussed label improvement trials as something SNY plans. So they are being led to believe it is SNY intention. Also, as noted today in this thread, the Afrezza medical professional advisory committee is apparently being led to believe that is the case... as it sure seems they are implying it isn't merely a non-inferior safety study being planned. I don't see why the trial would need to be particularly large or prolonged. Unlike a safety study, it is not looking for a rare event. A safety study needs thousands of patients in order to statistically tease out whether the are changes in the infrequent occurrence rate of something like cancer. If the occurrence rate for better blood sugar control is so infrequent as to need thousands, it would also be meaningless. Likewise, something like lower post meal spikes and better average glucose without increased dangerous hypos could be demonstrated with a CGM with a trial lasting 2-3 months... or maybe 4-5 if A1c readings desired. Your previous comment about patients likely being able to achieve the same control with traditional RAA/basal mix seems to be in total opposition to what many users are saying. I'm not a diabetes specialist but have taken control theory in engineering curriculum and it certainly makes total sense to me that have an RAA with a time constant that doesn't match what one wants to eat would pose far more problems than Afrezza that in some circumstances may have too brief action. Granted if a patient were willing to always eat a meal to match RAA's long tail, they might be able to simplify their life... but they also would likely pack on pounds to their health detriment as they would be needing to always plan for a fat laden meal that takes hours to digest and generates enough blood sugar for the body's cells (many of them fat cells) to feast on for hours. RAA's simply present trade offs... put up with higher post meal spikes and subsequent A1c, or deal with the fact that the RAA tail doesn't match the digestion rate of a healthy diet. |
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Post by mnholdem on Dec 15, 2015 12:14:09 GMT -5
"I heard it on the internet, so I know it must be the truth."
- Abraham Lincoln
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Post by mssciguy on Dec 15, 2015 12:17:37 GMT -5
"I heard it on the internet, so I know it must be the truth." - Abraham Lincoln .-..-. .. / .... . .- .-. -.. / .. - / --- -. / - .... . / .. -. - . .-. -. . - --..-- / ... --- / .. / -.- -. --- .-- / .. - / -- ..- ... - / -... . / - .... . / - .-. ..- - .... .-.-.- .-..-. / -....- / .- -... .-. .- .... .- -- / .-.. .. -. -.-. --- .-.. -. |
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Post by Deleted on Dec 15, 2015 12:21:07 GMT -5
"I heard it on the internet, so I know it must be the truth." - Abraham Lincoln .-..-. .. / .... . .- .-. -.. / .. - / --- -. / - .... . / .. -. - . .-. -. . - --..-- / ... --- / .. / -.- -. --- .-- / .. - / -- ..- ... - / -... . / - .... . / - .-. ..- - .... .-.-.- .-..-. / -....- / .- -... .-. .- .... .- -- / .-.. .. -. -.-. --- .-.. -. Mssciguy- The government was hiding the internet from us for quite some time. Is that on the list of conspiracies? |
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Post by dreamboatcruise on Dec 15, 2015 12:21:27 GMT -5
Great article once the portion of Jeremy starts. This author annoys me. He is such a hypocrite. The lung issues are a concern? Homeboy you eat like shit and drink a lot for a diabetic. Was this about a new treatment for diabetics or SNY dropping MNKD. Also great to hear he writes for a diabetes page but couldn't figure out how to use Afrezza correctly. I guess he could of asked Amy but then again she didnt know how to use either.... Someone evaluating risks differently than you do does not make them a hypocrite, unless you are implying he has some ulterior motive and what he expresses is not genuine. Yes, I do realize there are many who think any less than glowing comment about Afrezza must be orchestrated by the evil forces of the shorts. It is the doctor not the blogger that seems to have questioned SNY's commitment to Afrezza. |
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Post by mssciguy on Dec 15, 2015 12:27:34 GMT -5
.-..-. .. / .... . .- .-. -.. / .. - / --- -. / - .... . / .. -. - . .-. -. . - --..-- / ... --- / .. / -.- -. --- .-- / .. - / -- ..- ... - / -... . / - .... . / - .-. ..- - .... .-.-.- .-..-. / -....- / .- -... .-. .- .... .- -- / .-.. .. -. -.-. --- .-.. -. Mssciguy- The government was hiding the internet from us for quite some time. Is that on the list of conspiracies? The telegraph is still there BTW, you want a conspiracy? Guy on ymb says that MNKD is traded with lots ending in 05, both bid and ask, only equity like that on Level 2. Conspiracies are fact, and what keeps "The Street" moving, you know better than we do! Have you seen the Cramer youtube video where he makes confessions thinking the camera is not on? |
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Post by Deleted on Dec 15, 2015 12:31:52 GMT -5
"Users report...." Therein lies a problem. To really compare, you need some sort of well documented lifestyle/therapy history before and after starting afrezza. More importantly for afrezza, there needs to be solid clinical documentation to show insurance companies that patients in general are getting consistent improved results and that those results are in some fashion due to afrezza. This sort of documentation invariably requires a large and prolonged trial. I can't find anywhere that Sanofi has indicated whether they plan on any other trials other than those mandated by the FDA. MNKD has discussed label improvement trials as something SNY plans. So they are being led to believe it is SNY intention. Also, as noted today in this thread, the Afrezza medical professional advisory committee is apparently being led to believe that is the case... as it sure seems they are implying it isn't merely a non-inferior safety study being planned. I don't see why the trial would need to be particularly large or prolonged. Unlike a safety study, it is not looking for a rare event. A safety study needs thousands of patients in order to statistically tease out whether the are changes in the infrequent occurrence rate of something like cancer. If the occurrence rate for better blood sugar control is so infrequent as to need thousands, it would also be meaningless. Likewise, something like lower post meal spikes and better average glucose without increased dangerous hypos could be demonstrated with a CGM with a trial lasting 2-3 months... or maybe 4-5 if A1c readings desired. Your previous comment about patients likely being able to achieve the same control with traditional RAA/basal mix seems to be in total opposition to what many users are saying. I'm not a diabetes specialist but have taken control theory in engineering curriculum and it certainly makes total sense to me that have an RAA with a time constant that doesn't match what one wants to eat would pose far more problems than Afrezza that in some circumstances may have too brief action. Granted if a patient were willing to always eat a meal to match RAA's long tail, they might be able to simplify their life... but they also would likely pack on pounds to their health detriment as they would be needing to always plan for a fat laden meal that takes hours to digest and generates enough blood sugar for the body's cells (many of them fat cells) to feast on for hours. RAA's simply present trade offs... put up with higher post meal spikes and subsequent A1c, or deal with the fact that the RAA tail doesn't match the digestion rate of a healthy diet. If you have the engineering background then you know about precision, accuracy and reproducibility. In time, it will be well borne out that Afrezza produces much more predictable / consistent outcomes in terms of lower blood glucose levels for patients. It just so happens that the outcomes will mean blood glucose levels that are lower and reduced swings in blood glucose levels (std deviation). RAAs don't do this as well as Afrezza and neither does NN's 70/30. Mannkind knows this as does Novo and Lilly. High and low blood glucose levels adversely impact patient health but it is the big swings that cause much of the long term health complications. Two patients can have the same average glucose level or for that matter, the same A1c but the patient whose glucose levels are more stable (less big highs and big lows) in general, will have less long term health complications. The beauty of the Dexcom system is that it provides lots of information so clinicians and patients can see what is happening all day everyday to blood glucose levels. Why are big swings in blood glucose levels a problem: Read about it below in the Diabetes Control and Complications Trial aka:DCCTThis trial was done before continuous glucose monitoring was available. Anyone want to calculate the NPV of a patient with tightly controlled blood glucose levels in terms of reduced long term health complications? Sanofi pitches this along with ease of use of Afrezza (better patient compliance), less basal insulin needed (more $$ savings), Afrezza will decimate the pump industry (1 daily basal injection and Afrezza is a lot easier than messing with a pump), ..... Do you think Afrezza makes for a pretty good value proposition from a money and health perspective? Key points from the DCCT trial:DCCT Study Findings Intensive blood glucose control reduces risk of • eye disease 76% reduced risk • kidney disease 50% reduced risk • nerve disease 60% reduced risk EDIC Study Findings Intensive blood glucose control reduces risk of • any cardiovascular disease event 42% reduced risk • nonfatal heart attack, stroke, or death from cardiovascular causes 57% reduced risk www.niddk.nih.gov/about-niddk/research-areas/diabetes/dcct-edic-diabetes-control-complications-trial-follow-up-study/Documents/DCCT-EDIC_508.pdfGreat article posted at Diabetes Mine today about San Diego. Jay posted it on another part of this board. |
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Post by Deleted on Dec 15, 2015 12:46:52 GMT -5
Great article once the portion of Jeremy starts. This author annoys me. He is such a hypocrite. The lung issues are a concern? Homeboy you eat like shit and drink a lot for a diabetic. Was this about a new treatment for diabetics or SNY dropping MNKD. Also great to hear he writes for a diabetes page but couldn't figure out how to use Afrezza correctly. I guess he could of asked Amy but then again she didnt know how to use either.... Someone evaluating risks differently than you do does not make them a hypocrite, unless you are implying he has some ulterior motive and what he expresses is not genuine. Yes, I do realize there are many who think any less than glowing comment about Afrezza must be orchestrated by the evil forces of the shorts. It is the doctor not the blogger that seems to have questioned SNY's commitment to Afrezza. I am sorry but I respectfully disagree. The author Mike Hoskins takes a lot of pictures of unhealthy food and alcoholic beverages and posts them on his twitter account. I am sure I do not need to explain how a poor diet and drinking alcohol with diabetes is not too bright for his long term health. Its no different then a smoker saying I wont take Afrezza because of the unknown lung issues. I have no idea what his motives are. It seems Afrezzauser has already publicly questioned his motives. I am far from a short conspirator if that is what you are implying. This is all plain as day on Twitter. I am also reading the article different then you. I see it that he is making the comments about SNY dropping Afrezza not the Dr. He clearly states his opinion about SNY dropping Afrezza and then transitions into the Dr's comments. |
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Post by Deleted on Dec 15, 2015 12:52:14 GMT -5
Mssciguy- The government was hiding the internet from us for quite some time. Is that on the list of conspiracies? The telegraph is still there BTW, you want a conspiracy? Guy on ymb says that MNKD is traded with lots ending in 05, both bid and ask, only equity like that on Level 2. Conspiracies are fact, and what keeps "The Street" moving, you know better than we do! Have you seen the Cramer youtube video where he makes confessions thinking the camera is not on? yes, I have seen the video. Have you ever seen Jonathan Stewart rip Cramer? Pretty funny stuff. |
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Post by Deleted on Dec 15, 2015 12:54:28 GMT -5
Someone evaluating risks differently than you do does not make them a hypocrite, unless you are implying he has some ulterior motive and what he expresses is not genuine. Yes, I do realize there are many who think any less than glowing comment about Afrezza must be orchestrated by the evil forces of the shorts. It is the doctor not the blogger that seems to have questioned SNY's commitment to Afrezza. I am sorry but I respectfully disagree. The author Mike Hoskins takes a lot of pictures of unhealthy food and alcoholic beverages and posts them on his twitter account. I am sure I do not need to explain how a poor diet and drinking alcohol with diabetes is not too bright for his long term health. Its no different then a smoker saying I wont take Afrezza because of the unknown lung issues. I have no idea what his motives are. It seems Afrezzauser has already publicly questioned his motives. I am far from a short conspirator if that is what you are implying. This is all plain as day on Twitter. I am also reading the article different then you. I see it that he is making the comments about SNY dropping Afrezza not the Dr. He clearly states his opinion about SNY dropping Afrezza and then transitions into the Dr's comments. Here is Mike on his website talking about how the low alarm on his Dexcom sometimes keeps him up so he turns it off. If he used Afrezza, he could keep his alarm on and he would never hear it because the nighttime low issue would no longer exist. www.thediabeticscornerbooth.com |
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Post by Deleted on Dec 15, 2015 13:03:56 GMT -5
I am sorry but I respectfully disagree. The author Mike Hoskins takes a lot of pictures of unhealthy food and alcoholic beverages and posts them on his twitter account. I am sure I do not need to explain how a poor diet and drinking alcohol with diabetes is not too bright for his long term health. Its no different then a smoker saying I wont take Afrezza because of the unknown lung issues. I have no idea what his motives are. It seems Afrezzauser has already publicly questioned his motives. I am far from a short conspirator if that is what you are implying. This is all plain as day on Twitter. I am also reading the article different then you. I see it that he is making the comments about SNY dropping Afrezza not the Dr. He clearly states his opinion about SNY dropping Afrezza and then transitions into the Dr's comments. Here is Mike on his website talking about how the low alarm on his Dexcom sometimes keeps him up so he turns it off. If he used Afrezza, he could keep his alarm on and he would never hear it because the nighttime low issue would no longer exist. www.thediabeticscornerbooth.comThanks. I was thinking maybe I was being too harsh but not so much after reading that. |
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Post by ezrasfund on Dec 15, 2015 13:05:44 GMT -5
My first reaction is to say that investors shouldn't be criticizing bloggers on diabetes web sites, like Mike H. But I do have to say that Mike's intro is where the SNY dropping Afrezza talk is found, and you can click on the link to the Motley Fool article on the same subject (not the wonders of Afrezza), so I guess Mike has crossed a line.
That being said, the Dr's report on the San Diego meeting includes some incredible comments. It is hard to imagine that someone can't make money selling this stuff.
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Post by mssciguy on Dec 15, 2015 13:09:37 GMT -5
The telegraph is still there BTW, you want a conspiracy? Guy on ymb says that MNKD is traded with lots ending in 05, both bid and ask, only equity like that on Level 2. Conspiracies are fact, and what keeps "The Street" moving, you know better than we do! Have you seen the Cramer youtube video where he makes confessions thinking the camera is not on? yes, I have seen the video. Have you ever seen Jonathan Stewart rip Cramer? Pretty funny stuff. Apparently Motley Fool works in the same ways, writing hit pieces about Mannkind while recommending Novo.... maybe it's as easy as buying some ad space. Just like any kind of hanky panky sooner or later people talk. From all of the reports of patients finally getting their Afrezza after long waits, Friday mornings might be something to look forward to. |
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