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Post by victoria on May 18, 2016 7:34:47 GMT -5
Thanks madog reading what you say I entirely agree. I think it does imply an important development. I had missed ghat mnkd had a nasal inhaler somehow.
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Post by prolux on May 21, 2016 8:13:10 GMT -5
Flextronics is a contract manufacturer commissioned to develop the inhaler. The question that I have is who really owns the design/patent for the inhaler ? Is it MNKD, or an international subsidiary, or Optinose ? Who is licensing to whom ? Also, the SNIFF study out of UW has already lead to late stage FDA trials via Eli Lilly (Humalog). Is that competition for an RLS inhaled treatment for some Alzheimer's patients, or cooperation ? I state some Alzheimers patients, as data from the UW study clearly shows that only a portion of patients respond to the use of insulin. There are multiple factors (including high cholesterol) involved in the genesis of what we have termed Alzheimers. There are actually 5 or 6 types of dementia and some are likely misdiagnosed as Alzheimers. A diagnosis of Alzheimers requires the presence of Amyloid Beta plaques, yet I don't see that all supposed Alzheimers patients have had a biopsy. Also the converse applies: my father (now 71) had a brain hemorrhage almost (2) years ago and the biopsy clearly showed amyloid beta plaques as the cause. His doctors have not given a diagnosis of Alzheimers, possibly because it has not yet progressed to major cognitive decline, but it's getting there. I digress; my point with the various types of dementia is that some are apparently influenced by the glucose/insulin regulation in the brain, while others (vascular dementia) are not. What is needed is a means of determining which "Alzheimers", or dementia patients may benefit from inhaled (nasal) insulin. This will both help ensure that the right patient population is treated and that any trial participants show the best possible results.
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Post by cm5 on May 21, 2016 9:23:48 GMT -5
Answering Prolux concerns that dementia from altered metabolism and from vascular changes are different----see below. It's really all part of a spectrum. Report cited below is an excellent read, and I have cited it another thread-- Vascular Dysfunction Associated with Type 2 Diabetes and Alzheimer’s Disease: A Potential Etiological Linkage
Med Sci Monit Basic Res. 2014; 20: 118–129. Published online 2014 Aug 1. doi: 10.12659/MSMBR.891278 Fuzhou Wang,1,2,A,B,D,E,F,G Xirong Guo,3,B,D,E,F Xiaofeng Shen,1,B,D,E,F Richard M. Kream,4,D,E,F,G Kirk J. Mantione,4,D,E,F,G and George B. Stefano4,A,B,D,E,F,G 1Department of Anesthesiology and Critical Care Medicine, Nanjing Maternit and Child Health Care Hospital, Nanjing Medical University, Nanjing, China 2Division of Neuroscience, The Bonoi Academy of Science and Education, Chapel Hill, NC, U.S.A. 3Institutes of Pediatrics, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China 4Neuroscience Research Institute, State University of New York – College at Old Westbury, Old Westbury, NY, U.S.A.
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Post by cathode on Jun 6, 2016 7:24:53 GMT -5
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Post by kc on Jun 6, 2016 8:35:45 GMT -5
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Post by avichen on Jun 6, 2016 8:59:17 GMT -5
Why don't they just register 'RLS'
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Post by mnkdfann on Jun 6, 2016 9:26:01 GMT -5
Why don't they just register 'RLS' RLS is already popularly identified with Restless Leg Syndrome.
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Post by peppy on Jun 6, 2016 9:32:59 GMT -5
If applicant does not respond to this Office action within six months of the issue/mailing date,
The receptor issue; Types of Receptors (5 types shown) www.boundless.com/biology/textbooks/boundless-biology-textbook/cell-communication-9/signaling-molecules-and-cellular-receptors-83/types-of-receptors-381-11607/
IDENTIFICATION OF GOODS REQUIRES AMENDMENT/CLASS 5 ONLY
The wording “pharmaceutical preparations for human use; inhalers sold pre-filled with pharmaceutical preparations” in the identification of goods in Class 5 must be clarified because it is indefinite. [...] Applicant must specify the nature and intended purpose and use of these goods.
Applicant may adopt the following identification of goods in Class 5, if accurate. TMEP §1402.01.
Class 5
Pharmaceutical preparations for human use for {indicate intended use, e.g., the treatment of skin disorders, use in chemotherapy, treating diabetes}; inhalers sold pre-filled with pharmaceutical preparations, namely, {indicate specific pharmaceutical preparations} ; plant extracts for pharmaceutical purposes ---------------------------------------------------------------------------------------------------------------------------------------------------------------------- www.uspto.gov/ want to know, what, when, where and why.
Jane Powell the attorney? hehe
Matt did say, we would be hearing more about RLS in the future. My guess is in 6 months or less.
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Post by cm5 on Jun 10, 2016 23:16:43 GMT -5
Going out on a limb-- more views above the forest--- More about RLS Website---keeping also in mind that the trademark lists "plant extracts"----Searched online images of redwood groves, forests, parks, trails, etc etc online today----and seems this is the site photographed for RLS' website: www.receptorlife.com/ and www.redwoodhikes.com/Oregon/ORT.html, as well as www.google.com/search?q=redwood+forest+chetco+river, + oregon and traveloregon.com/trip-ideas/grants-getaways/oregon-redwoods/Long and short, this trail is along the Chetco River, not far from Vancouver, Washington. And, Chairman of the Board of Directors of Mannkind is Kent Kresa, who has Vancouver, WA connections.And, from Wikipedia, see below about Vancouver, WA:The Vancouver economy is characterized by border economics with neighboring Portland, Oregon. The state of Washington levies no individual or corporate income taxes and levies a property tax below the national average and a sales tax above the national median.[37] The State of Oregon has even lower property taxes and no sales tax but one of the highest state income taxes.[38] As a result, many Vancouver residents prefer to shop in neighboring Portland where they do not pay sales taxes then live and work in Vancouver where they do not pay state income tax. (Washington residents who work in Oregon must pay Oregon income tax.) For the same reasons, the city is popular with retirees. Conversely, the city is less favored by students and young adults.[citation needed] In 2003, 70% of workers in Vancouver worked in Clark County. There is a risk in sales tax avoidance because Washington has a use tax due on all purchases made in Oregon that are then returned to Washington. Vancouver residents "shop at their own risk" when attempting to avoid the sales tax in Washington, although the rule is rarely, if ever, enforced[citation needed] except for purchases requiring registration, such as motor vehicles.
The taxation and demographics of the area depresses the retail sector of Vancouver's economy.[citation needed] Oregon has stricter development laws to protect the timber industry[citation needed]; therefore, Vancouver tends to attract a higher proportion of the region's sprawling development
And, review Mr. Kresa's corporate career, specifically at Fluor:newsroom.fluor.com/press-release/company/two-fluor-board-members-step-down-april Kresa and Woolsey both most recently served on Fluor’s audit committee. Woolsey also served on Fluor’s governance committee, while Kresa served on the firm’s organization and compensation committee. And, read about Fluor. They diversify and take over something essential. Oil has tanked, so what to do? In particular: www.nytimes.com/1981/01/16/business/fluor-buys-shares-in-genentech-inc.html And, finally, Oregon is center of cannabanoid research, commercialization. marijuanapolitics.com/the-future-oregon-cannabis-research-institute/
It's a short commute from Vancouver, WA to Portland, Oregon. It's less than two hours to Corvalis, Oregon State, one the two top tier research institutes in the Northwest. Long and short, I don't think it's the new cannabanoid companies like VeritasPharma that are funding Mannkind. It has to be something enormous to pump in the funds. Could it be Fluor? Is Fluor repeating its success as it did with with Genentech?
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Post by Deleted on Jun 10, 2016 23:24:44 GMT -5
Going out on a limb-- more views above the forest--- More about RLS Website---keeping also in mind that the trademark lists "plant extracts"----Searched online images of redwood groves, forests, parks, trails, etc etc online today----and seems this is the site photographed for RLS' website: www.receptorlife.com/ and www.redwoodhikes.com/Oregon/ORT.html, as well as www.google.com/search?q=redwood+forest+chetco+river, + oregon and traveloregon.com/trip-ideas/grants-getaways/oregon-redwoods/Long and short, this trail is along the Chetco River, not far from Vancouver, Washington. And, Chairman of the Board of Directors of Mannkind is Kent Kresa, who has Vancouver, WA connections.And, from Wikipedia, see below about Vancouver, WA:The Vancouver economy is characterized by border economics with neighboring Portland, Oregon. The state of Washington levies no individual or corporate income taxes and levies a property tax below the national average and a sales tax above the national median.[37] The State of Oregon has even lower property taxes and no sales tax but one of the highest state income taxes.[38] As a result, many Vancouver residents prefer to shop in neighboring Portland where they do not pay sales taxes then live and work in Vancouver where they do not pay state income tax. (Washington residents who work in Oregon must pay Oregon income tax.) For the same reasons, the city is popular with retirees. Conversely, the city is less favored by students and young adults.[citation needed] In 2003, 70% of workers in Vancouver worked in Clark County. There is a risk in sales tax avoidance because Washington has a use tax due on all purchases made in Oregon that are then returned to Washington. Vancouver residents "shop at their own risk" when attempting to avoid the sales tax in Washington, although the rule is rarely, if ever, enforced[citation needed] except for purchases requiring registration, such as motor vehicles.
The taxation and demographics of the area depresses the retail sector of Vancouver's economy.[citation needed] Oregon has stricter development laws to protect the timber industry[citation needed]; therefore, Vancouver tends to attract a higher proportion of the region's sprawling development
And, review Mr. Kresa's corporate career, specifically at Fluor:newsroom.fluor.com/press-release/company/two-fluor-board-members-step-down-april Kresa and Woolsey both most recently served on Fluor’s audit committee. Woolsey also served on Fluor’s governance committee, while Kresa served on the firm’s organization and compensation committee. And, read about Fluor. They diversify and take over something essential. Oil has tanked, so what to do? In particular: www.nytimes.com/1981/01/16/business/fluor-buys-shares-in-genentech-inc.html And, finally, Oregon is center of cannabanoid research, commercialization. marijuanapolitics.com/the-future-oregon-cannabis-research-institute/
It's a short commute from Vancouver, WA to Portland, Oregon. It's less than two hours to Corvalis, Oregon State, one the two top tier research institutes in the Northwest. Long and short, I don't think it's the new cannabanoid companies like VeritasPharma that are funding Mannkind. It has to be something enormous to pump in the funds. Could it be Fluor? Is Fluor repeating its success as it did with with Genentech? www.squarespace.com/coverpage/
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Post by cm5 on Jun 10, 2016 23:31:42 GMT -5
Understand that the image is listed on this website---
But, is there a "Why" for this particular image?
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Post by Deleted on Jun 10, 2016 23:37:06 GMT -5
Understand that the image is listed on this website--- But, is there a "Why" for this particular image? based on the trade mark related to plant extracts..and the intern building the website thought it would be suitable?
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Post by BlueCat on Jun 18, 2016 18:21:38 GMT -5
Ok. Though clearly in foil hat territory, I haven't been too optimistic on the secret MS or Google connections on RLS, other than the possibility that a large investor may also be involved with those companies. But for those following the cannabis and/or Paul Allen potential - try this just posted today: www.cnbc.com/2016/06/16/microsoft-scores-its-first-ever-pot-partnership.html
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Post by nylefty on Jun 18, 2016 19:47:31 GMT -5
Ok. Though clearly in foil hat territory, I haven't been too optimistic on the secret MS or Google connections on RLS, other than the possibility that a large investor may also be involved with those companies. But for those following the cannabis and/or Paul Allen potential - try this just posted today: www.cnbc.com/2016/06/16/microsoft-scores-its-first-ever-pot-partnership.htmlPaul Allen is involved in many businesses, but Microsoft hasn't been one of them for many years.
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Post by xoxoxoxo on Jun 18, 2016 22:35:42 GMT -5
Assuming RLS is planning a cannabis product using technosphere (big assumption, please just go with it)... How would the delivery be better than a vaping device that just delivers the THC. I'm just trying to understand the benefit here.
I get smoking is bad because of cancer. But what about vaping?
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