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Post by centralcoastinvestor on Jan 23, 2016 11:34:35 GMT -5
About a year and a half ago I posted an idea on the YMB about an approach to introducing Afrezza to the medical world at an upcoming ADA Scientific Sessions. Since Sanofi was going to do such a great job of handling all of the marketing, I let my idea go away. After all, Sanofi was going to make Afrezza a big hit. Right? Grrrrrrrr!!!! But I digress.....
So I wanted to float the idea again to all of you on Proboards to see what you think. Perhaps, if you think it has merit, we can pass it along to Mnkd management. So here goes:
Picture this: You are an endo who is attending the 2016 Scientific Sessions. You have heard vaguely about Afrezza, a new inhaled insulin but think it is just another inhaled insulin. You decide to go ahead and attend the session on Afrezza anyway just because your curious. So you decide to go 15 minutes early to make sure you get a seat just in case the room fills. As you walk in you notice some odd things that are in the room. First, you notice that there are four large screens set up behind a platform next to the speakers podium. You then notice that there is a dinner table set up in front as well with four people talking with the person who will be presenting on Afrezza. You laugh to yourself because it looks like they are preparing to eat while the speaker is giving his presentation. Now you are interested in what is going to happen here. At the very least, it will be entertaining you think.
As you sit there waiting for the presentation to begin, more people file in and the auditorium is mostly filled. You notice that the screens behind the stage have now been energized and it looks like CGM readings are showing up on the screens. You make the connection that each screen shows the CGM reading of each of the four people now sitting down to have a meal. It looks like a full spaghetti dinner. How odd you think. The speaker then steps up to the podium and begins. You hardly notice what the speaker is saying because you are watching what appears to be diabetics eating a heavy meal. About 10 minutes into the talk all four of the people load a cartridge into this small whistle size object and take a puff of what you believe is Afrezza. You are now intently watching the CGM readings as it appeared that the blood glucose was beginning to go up for 3 of the diners. However, you also notice that one of the people that took a puff hasn't eaten anything yet. You are a little worried for that person because you are afraid the insulin will make that person's BG crash if he doesn't have anything to eat soon.
While you sit there partially listening to the speaker and watching those CGM readings, you are amazed that this heavy meal has not caused any of the three people to have any significant spike in BG. How is that possible you think. What is even more amazing is that the BG level for the person who still hasn't eaten anything doesn't appear to be drastically dropping. You then kick yourself for not paying more attention to the speaker. You cannot believe what you just saw. Is it possible that this inhaled insulin product was able to maintain BG in real time? That's just not possible. But you saw it with your own eyes. Wow, you think. You make a mental note to get more data on this Afrezza. But first you want to speak with someone.
Instead of going up to talk with the Afrezza speaker, you go up and speak with the people who were eating the meal. You are particularly interested in speaking with the person who never actually ate. You want to know how they could be so confident in the product that they would risk hypoglycemia. After speaking with the folks who were there as diabetics you conclude that you need to find out more about Afrezza.
So, would this kind of presentation be allowed at the ADA? Could this type of presentation be used in other gatherings? Maybe at a health conferences? Anyway, what do you think?
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nsmyth
Lab Rat
Posts: 43
Sentiment: Long
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Post by nsmyth on Jan 23, 2016 12:29:21 GMT -5
WOW! that would be impactful. I could even suggest a few of the participants, Afrezzauser and the guy from down under for starters!
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Post by lfalcon on Jan 23, 2016 13:25:45 GMT -5
I think that is a GREAT idea. Showing is always more effective than telling.
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Post by mnkdorbust on Jan 23, 2016 13:41:39 GMT -5
Also people can relate better to it. Seeing is believing. Technically you wouldn't have to say anything as the readings are saying more than you could ever say.
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Post by centralcoastinvestor on Jan 23, 2016 14:31:51 GMT -5
Taking this a step further, why not see if you could team up with the lead maker of the CGMs to share costs of making the presentation. Showing real time management of diabetes would be far better than just saying it works. This would also serve as a big plug for CGMs in the management of diabetes. You could also take the show on the road so to speak. Sharing costs would also help Mannkind keep the burn rate lower.
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Post by irrationalexubera on Jan 23, 2016 19:47:09 GMT -5
this is a fantastic proposal. i absolutely think it can work, and should.
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Post by stevil on Jan 23, 2016 20:14:11 GMT -5
About a year and a half ago I posted an idea on the YMB about an approach to introducing Afrezza to the medical world at an upcoming ADA Scientific Sessions. Since Sanofi was going to do such a great job of handling all of the marketing, I let my idea go away. After all, Sanofi was going to make Afrezza a big hit. Right? Grrrrrrrr!!!! But I digress.....
So I wanted to float the idea again to all of you on Proboards to see what you think. Perhaps, if you think it has merit, we can pass it along to Mnkd management. So here goes:
Picture this: You are an endo who is attending the 2016 Scientific Sessions. You have heard vaguely about Afrezza, a new inhaled insulin but think it is just another inhaled insulin. You decide to go ahead and attend the session on Afrezza anyway just because your curious. So you decide to go 15 minutes early to make sure you get a seat just in case the room fills. As you walk in you notice some odd things that are in the room. First, you notice that there are four large screens set up behind a platform next to the speakers podium. You then notice that there is a dinner table set up in front as well with four people talking with the person who will be presenting on Afrezza. You laugh to yourself because it looks like they are preparing to eat while the speaker is giving his presentation. Now you are interested in what is going to happen here. At the very least, it will be entertaining you think.
As you sit there waiting for the presentation to begin, more people file in and the auditorium is mostly filled. You notice that the screens behind the stage have now been energized and it looks like CGM readings are showing up on the screens. You make the connection that each screen shows the CGM reading of each of the four people now sitting down to have a meal. It looks like a full spaghetti dinner. How odd you think. The speaker then steps up to the podium and begins. You hardly notice what the speaker is saying because you are watching what appears to be diabetics eating a heavy meal. About 10 minutes into the talk all four of the people load a cartridge into this small whistle size object and take a puff of what you believe is Afrezza. You are now intently watching the CGM readings as it appeared that the blood glucose was beginning to go up for 3 of the diners. However, you also notice that one of the people that took a puff hasn't eaten anything yet. You are a little worried for that person because you are afraid the insulin will make that person's BG crash if he doesn't have anything to eat soon.
While you sit there partially listening to the speaker and watching those CGM readings, you are amazed that this heavy meal has not caused any of the three people to have any significant spike in BG. How is that possible you think. What is even more amazing is that the BG level for the person who still hasn't eaten anything doesn't appear to be drastically dropping. You then kick yourself for not paying more attention to the speaker. You cannot believe what you just saw. Is it possible that this inhaled insulin product was able to maintain BG in real time? That's just not possible. But you saw it with your own eyes. Wow, you think. You make a mental note to get more data on this Afrezza. But first you want to speak with someone.
Instead of going up to talk with the Afrezza speaker, you go up and speak with the people who were eating the meal. You are particularly interested in speaking with the person who never actually ate. You want to know how they could be so confident in the product that they would risk hypoglycemia. After speaking with the folks who were there as diabetics you conclude that you need to find out more about Afrezza.
So, would this kind of presentation be allowed at the ADA? Could this type of presentation be used in other gatherings? Maybe at a health conferences? Anyway, what do you think?
I'm a little confused. I hope you're not really saying what I think you're saying. I thought this board was usually pretty well informed about stuff, but maybe not... Where do you guys get your info from? The first issue I have with the 4th contestant that doesn't eat- It's very common for diabetics to take their insulin about a half hour before they eat... so not eating immediately wouldn't really be that big of a deal... That's pretty normal behavior for a diabetic. Then, I hope you're not really wanting someone to take a bunch of insulin without eating... It's not impossible to have a hypoglycemic event on Afrezza. If someone doesn't compensate by adding carbs right away, they still could pass out and go into a coma and possibly die if not given glucose relatively soon. It's just less likely to happen on Afrezza because it's easier to control and apparently you need more of it than normal insulin, so the early users were probably starting on the lower end of what they needed. Since it works so quickly, you don't need to take a bunch of it to meet the numbers you want so you can dose it low and add on if you need to. But no, it would not be a good idea at all to take a dose of insulin and then not eat anything.
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Post by LosingMyBullishness on Jan 23, 2016 20:23:06 GMT -5
Taken from Stevil's comment: It should be added in such a presentation that none of the diabetics have been dosing insulin for the last couple of hours. Otherwise it could be just good timing.
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Post by centralcoastinvestor on Jan 24, 2016 1:42:09 GMT -5
About a year and a half ago I posted an idea on the YMB about an approach to introducing Afrezza to the medical world at an upcoming ADA Scientific Sessions. Since Sanofi was going to do such a great job of handling all of the marketing, I let my idea go away. After all, Sanofi was going to make Afrezza a big hit. Right? Grrrrrrrr!!!! But I digress.....
So I wanted to float the idea again to all of you on Proboards to see what you think. Perhaps, if you think it has merit, we can pass it along to Mnkd management. So here goes:
Picture this: You are an endo who is attending the 2016 Scientific Sessions. You have heard vaguely about Afrezza, a new inhaled insulin but think it is just another inhaled insulin. You decide to go ahead and attend the session on Afrezza anyway just because your curious. So you decide to go 15 minutes early to make sure you get a seat just in case the room fills. As you walk in you notice some odd things that are in the room. First, you notice that there are four large screens set up behind a platform next to the speakers podium. You then notice that there is a dinner table set up in front as well with four people talking with the person who will be presenting on Afrezza. You laugh to yourself because it looks like they are preparing to eat while the speaker is giving his presentation. Now you are interested in what is going to happen here. At the very least, it will be entertaining you think.
As you sit there waiting for the presentation to begin, more people file in and the auditorium is mostly filled. You notice that the screens behind the stage have now been energized and it looks like CGM readings are showing up on the screens. You make the connection that each screen shows the CGM reading of each of the four people now sitting down to have a meal. It looks like a full spaghetti dinner. How odd you think. The speaker then steps up to the podium and begins. You hardly notice what the speaker is saying because you are watching what appears to be diabetics eating a heavy meal. About 10 minutes into the talk all four of the people load a cartridge into this small whistle size object and take a puff of what you believe is Afrezza. You are now intently watching the CGM readings as it appeared that the blood glucose was beginning to go up for 3 of the diners. However, you also notice that one of the people that took a puff hasn't eaten anything yet. You are a little worried for that person because you are afraid the insulin will make that person's BG crash if he doesn't have anything to eat soon.
While you sit there partially listening to the speaker and watching those CGM readings, you are amazed that this heavy meal has not caused any of the three people to have any significant spike in BG. How is that possible you think. What is even more amazing is that the BG level for the person who still hasn't eaten anything doesn't appear to be drastically dropping. You then kick yourself for not paying more attention to the speaker. You cannot believe what you just saw. Is it possible that this inhaled insulin product was able to maintain BG in real time? That's just not possible. But you saw it with your own eyes. Wow, you think. You make a mental note to get more data on this Afrezza. But first you want to speak with someone.
Instead of going up to talk with the Afrezza speaker, you go up and speak with the people who were eating the meal. You are particularly interested in speaking with the person who never actually ate. You want to know how they could be so confident in the product that they would risk hypoglycemia. After speaking with the folks who were there as diabetics you conclude that you need to find out more about Afrezza.
So, would this kind of presentation be allowed at the ADA? Could this type of presentation be used in other gatherings? Maybe at a health conferences? Anyway, what do you think?
I'm a little confused. I hope you're not really saying what I think you're saying. I thought this board was usually pretty well informed about stuff, but maybe not... Where do you guys get your info from? The first issue I have with the 4th contestant that doesn't eat- It's very common for diabetics to take their insulin about a half hour before they eat... so not eating immediately wouldn't really be that big of a deal... That's pretty normal behavior for a diabetic. Then, I hope you're not really wanting someone to take a bunch of insulin without eating... It's not impossible to have a hypoglycemic event on Afrezza. If someone doesn't compensate by adding carbs right away, they still could pass out and go into a coma and possibly die if not given glucose relatively soon. It's just less likely to happen on Afrezza because it's easier to control and apparently you need more of it than normal insulin, so the early users were probably starting on the lower end of what they needed. Since it works so quickly, you don't need to take a bunch of it to meet the numbers you want so you can dose it low and add on if you need to. But no, it would not be a good idea at all to take a dose of insulin and then not eat anything. Hey Stevil, I appreciate the feedback. When Sam Finta (Afrezzauser) first began taking Afrezza, he documented much of how he used Afrezza. This included pushing the limits of Afrezza to see what was possible. He did an experiment where he did not eat anything and took a dose of Afrezza (not sure what dose size). He had a gallon of orange juice on hand just in case his BC dropped too low. He also had a CGM to watch his BC in real time. The results of his experiment showed that Afrezza didn't drop his BC too low. This is consistent with the fast acting abilities of Afrezza. Now, I am not suggesting that Mannkind do a presentation that would put anyone in danger. So clearly they would have to be confident in the results before they would put it on display. But Afrezza users have reported that it is nearly impossible to get hypoglycemia on Afrezza. Al Mann consistently stated that Afrezza nearly mimics how the pancreas works. The pancreas does not need to perfectly titrate the amount of insulin it sends into the body because in leaves so quickly. So does Afrezza. You mention that it is common for people to take insulin 30 minutes before a meal. That is what people need to do if they use normal fast acting insulin. It takes time for it to work and stays in the body way too long. What is not common is to take additional insulin like the other 3 diners. This would cause insulin stacking. Afrezza is the only insulin you can get away with taking at meal time and even taking it again a little later if the first dose is not enough. Then it is quickly out of the body. My point is to show the amazing speed and control Afrezza not just tell people how well it works. With CGMs, this can be done. It may not take the shape of what I have proposed but anything that shows what Afrezza does will have high impact.
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Post by coo2002coo on Jan 24, 2016 6:45:40 GMT -5
About a year and a half ago I posted an idea on the YMB about an approach to introducing Afrezza to the medical world at an upcoming ADA Scientific Sessions. Since Sanofi was going to do such a great job of handling all of the marketing, I let my idea go away. After all, Sanofi was going to make Afrezza a big hit. Right? Grrrrrrrr!!!! But I digress.....
So I wanted to float the idea again to all of you on Proboards to see what you think. Perhaps, if you think it has merit, we can pass it along to Mnkd management. So here goes:
Picture this: You are an endo who is attending the 2016 Scientific Sessions. You have heard vaguely about Afrezza, a new inhaled insulin but think it is just another inhaled insulin. You decide to go ahead and attend the session on Afrezza anyway just because your curious. So you decide to go 15 minutes early to make sure you get a seat just in case the room fills. As you walk in you notice some odd things that are in the room. First, you notice that there are four large screens set up behind a platform next to the speakers podium. You then notice that there is a dinner table set up in front as well with four people talking with the person who will be presenting on Afrezza. You laugh to yourself because it looks like they are preparing to eat while the speaker is giving his presentation. Now you are interested in what is going to happen here. At the very least, it will be entertaining you think.
As you sit there waiting for the presentation to begin, more people file in and the auditorium is mostly filled. You notice that the screens behind the stage have now been energized and it looks like CGM readings are showing up on the screens. You make the connection that each screen shows the CGM reading of each of the four people now sitting down to have a meal. It looks like a full spaghetti dinner. How odd you think. The speaker then steps up to the podium and begins. You hardly notice what the speaker is saying because you are watching what appears to be diabetics eating a heavy meal. About 10 minutes into the talk all four of the people load a cartridge into this small whistle size object and take a puff of what you believe is Afrezza. You are now intently watching the CGM readings as it appeared that the blood glucose was beginning to go up for 3 of the diners. However, you also notice that one of the people that took a puff hasn't eaten anything yet. You are a little worried for that person because you are afraid the insulin will make that person's BG crash if he doesn't have anything to eat soon.
While you sit there partially listening to the speaker and watching those CGM readings, you are amazed that this heavy meal has not caused any of the three people to have any significant spike in BG. How is that possible you think. What is even more amazing is that the BG level for the person who still hasn't eaten anything doesn't appear to be drastically dropping. You then kick yourself for not paying more attention to the speaker. You cannot believe what you just saw. Is it possible that this inhaled insulin product was able to maintain BG in real time? That's just not possible. But you saw it with your own eyes. Wow, you think. You make a mental note to get more data on this Afrezza. But first you want to speak with someone.
Instead of going up to talk with the Afrezza speaker, you go up and speak with the people who were eating the meal. You are particularly interested in speaking with the person who never actually ate. You want to know how they could be so confident in the product that they would risk hypoglycemia. After speaking with the folks who were there as diabetics you conclude that you need to find out more about Afrezza.
So, would this kind of presentation be allowed at the ADA? Could this type of presentation be used in other gatherings? Maybe at a health conferences? Anyway, what do you think?
Wow. This is just an amazing demonstration & experience of a Real Time Diabetes Management at dinner which most diabetes dream of. It would be great of Matt can consider this sort of demonstration. Nothing is better worded than the true & real time experience being ENJOYED by patients!
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Post by garrett on Jan 24, 2016 6:59:12 GMT -5
Great idea - someone needs to email it to Matt
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Post by kball on Jan 24, 2016 7:52:21 GMT -5
Considering the conference is the last month of the 2nd quarter, my fear is they declare BK a month or 2 before that. But it's an interesting idea. Just not sure we will be able to get that far and the only thing that will give me confidence we will is back over 2.00 a share by feb or march.
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Post by ripano on Jan 24, 2016 7:52:38 GMT -5
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Post by tayl5 on Jan 24, 2016 8:26:45 GMT -5
Not sure it would fit in the context of a scientific session but could be perfect for a sponsored lunchtime event. I haven't been to an ADA meeting but most of the conferences I attend have noontime events where companies provide a box lunch to attendees and preach the gospel on their products. I could see a real-time demonstration of Afrezza fitting nicely into one of these one-hour lunch slots. It would be even more fun to have someone be the Brand X comparator, running the drill with a "fast-acting" insulin.
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Post by peppy on Jan 24, 2016 9:27:06 GMT -5
I love the idea of two to 3 people with Continuous glucose monitors shown eating and using afrezza at the ADA meeting. Sarcastically, Any chance Sanofi gives Mannkind the props? screencast.com/t/OZUFzADE screencast.com/t/Btgl0Mv1zjh8
Added: I my dreams, Afrezza users in the Afrezza booth with their continuous glucose monitors typed to their chests.
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