Post by stevil on Feb 6, 2016 16:01:21 GMT -5
Learning just now about how white adipose tissue can be converted to brown adipose tissue. Supposedly, someone is already working on figuring out the mechanism so they can formulate it into a drug.
The idea behind it is excess glucose gets stored in white fat for storage as fatty acids. There is some kind of adrenergic response in the body that then converts the white fat, storage fat, into brown fat. Brown fat is used predominantly for heat generation. The energy from metabolizing brown fat generates heat, in a term called thermogenesis. So your body essentially burns off all the excess fat and radiates it as heat.
If we could somehow be the first company to figure this out, it would be the greatest selling drug of all time. It would make Viagra look like child's play. (might have been a bad choice of words)
Wish we had more money for R&D to do stuff like this. Not sure if Matt reads this board, but figure out how to do this!
The idea behind it is excess glucose gets stored in white fat for storage as fatty acids. There is some kind of adrenergic response in the body that then converts the white fat, storage fat, into brown fat. Brown fat is used predominantly for heat generation. The energy from metabolizing brown fat generates heat, in a term called thermogenesis. So your body essentially burns off all the excess fat and radiates it as heat.
If we could somehow be the first company to figure this out, it would be the greatest selling drug of all time. It would make Viagra look like child's play. (might have been a bad choice of words)
Wish we had more money for R&D to do stuff like this. Not sure if Matt reads this board, but figure out how to do this!
and this medication should also help diabetics (in theory) by lowering insulin resistance. Smaller white adipose cells in leaner individuals, (compared to larger adipose cells in the overweight/obese) secretes more adiponectin, a hormone that helps with insulin sensitivity. So the leaner a person is, the more adiponectin gets secreted, the more sensitive they should be to insulin. Converting the bigger fat cells into smaller cells (by converting them to brown fat that will get metabolized as heat) would be a way to help this process without having to change diet or exercise. As long as the person kept the same lifestyle in regards to activity and didn't change their diet, they would lose weight simply by taking that drug.