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Post by fofos2000i on Mar 10, 2016 8:11:19 GMT -5
filed in 11/18/15, Kelly Kraft www.freepatentsonline.com/y2016/0067183.htmlDisclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery .... Example 1 Synthesis of Substituted DKP Analogs Example 2 Pharmacokinetics of GLP-1/DKP Analogues Administered Via Pulmonary Insufflation in Rats Example 3 Glucose Reduction in Rats Administered xDKP/Insulin (TI) Powders Example 4 Insulin Analysis in Rats Administered Substituted DKP/Insulin Example 5 Glucose and Insulin Analysis in Rats Administered Substituted DKP Powders |
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Post by mnkdnewb on Mar 10, 2016 12:17:20 GMT -5
filed in 11/18/15, Kelly Kraft www.freepatentsonline.com/y2016/0067183.htmlDisclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery .... Example 1 Synthesis of Substituted DKP Analogs Example 2 Pharmacokinetics of GLP-1/DKP Analogues Administered Via Pulmonary Insufflation in Rats Example 3 Glucose Reduction in Rats Administered xDKP/Insulin (TI) Powders Example 4 Insulin Analysis in Rats Administered Substituted DKP/Insulin Example 5 Glucose and Insulin Analysis in Rats Administered Substituted DKP Powders Just another patent or is there something special about this one in particular? |
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Post by mindovermatter on Mar 10, 2016 12:24:19 GMT -5
filed in 11/18/15, Kelly Kraft www.freepatentsonline.com/y2016/0067183.htmlDisclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery .... Example 1 Synthesis of Substituted DKP Analogs Example 2 Pharmacokinetics of GLP-1/DKP Analogues Administered Via Pulmonary Insufflation in Rats Example 3 Glucose Reduction in Rats Administered xDKP/Insulin (TI) Powders Example 4 Insulin Analysis in Rats Administered Substituted DKP/Insulin Example 5 Glucose and Insulin Analysis in Rats Administered Substituted DKP Powders Just another patent or is there something special about this one in particular? It appears it is an update to an existing patent. Unless I am misinformed, this is typical. It appears that the company continues to refine a patented process and when they do, they apply for a patent to protect that new process. This appears to be one of those instances. CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser. No. 14/536,168, filed Nov. 7, 2014, which is a continuation of U.S. patent application Ser. No. 13/649,430, filed Oct. 11, 2012, now U.S. Pat. No. 8,906,926, which is a continuation of U.S. patent application Ser. No. 12/649,210, filed Dec. 29, 2009, now U.S. Pat. No. 8,314,106, which claims priority under 35 U.S.C. §119(e) to U.S. Provisional Patent Application No. 61/141,207 filed Dec. 29, 2008; the entire contents of each of these applications is incorporated by reference herein. |
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Post by peppy on Mar 10, 2016 12:41:49 GMT -5
A cover all bases patent for technosphere. (?)
disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery
The F in FDKP can be replaced. (?) xDKP ?
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Post by mnholdem on Mar 10, 2016 16:20:51 GMT -5
I'm particularly interested in knowing if there is a reason why MannKind is continuing to update it's foreign patents in certain countries. Spain and Israel, in particular, seem to get more patents filed than other countries. In fact, two patents for Spain (ES) were just updated within the past few weeks. |
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Post by peppy on Mar 10, 2016 19:57:10 GMT -5
A cover all bases patent for technosphere. (?)
disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery
The F in FDKP can be replaced. (?) xDKP ?
This is what this patent could be about. These particles can be administered by various routes of administration. As dry powders these particles can be delivered by inhalation to specific areas of the respiratory system, depending on particle size. Additionally, the particles can be made small enough for incorporation into an intravenous suspension dosage form. Oral delivery is also possible with the particles incorporated into a suspension, tablets or capsules; or dissolved in an appropriate solvent. Diketopiperazines may also facilitate absorption of an associated drug. Nonetheless difficulties can arise when diketopiperazines are diacids, or are in diacid form(s), due to the limited solubility of these diacids at non-basic pH (i.e., neutral or acid pH). Another difficulty arises because these diacid diketopiperazines may form disadvantageous association(s) with some drugs.
patents.justia.com/patent/9259471 |
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Post by mindovermatter on Mar 10, 2016 21:59:53 GMT -5
A cover all bases patent for technosphere. (?)
disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery
The F in FDKP can be replaced. (?) xDKP ?
This is what this patent could be about. These particles can be administered by various routes of administration. As dry powders these particles can be delivered by inhalation to specific areas of the respiratory system, depending on particle size. Additionally, the particles can be made small enough for incorporation into an intravenous suspension dosage form. Oral delivery is also possible with the particles incorporated into a suspension, tablets or capsules; or dissolved in an appropriate solvent. Diketopiperazines may also facilitate absorption of an associated drug. Nonetheless difficulties can arise when diketopiperazines are diacids, or are in diacid form(s), due to the limited solubility of these diacids at non-basic pH (i.e., neutral or acid pH). Another difficulty arises because these diacid diketopiperazines may form disadvantageous association(s) with some drugs.
patents.justia.com/patent/9259471come on Peppy, the F was replaced because Mannkind realized it could be mistaken for "F"udster. |
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