Any chance

[peppy]

Any chance MNKD shares  bought in part, because there is some research that Cannabinoids CBD is effective against Cancer and Technosphere is the perfect delivery system?

No heat required?

How Cannabinoids Cause Cancer Cells to Die

"Ceramide kills the mitochondria of the cell."

www.youtube.com/watch?v=wLoRFTbIakk

Ceramide signaling in apoptosis

www.ncbi.nlm.nih.gov/pubmed/9374036

Ceramide acts as a second messenger in activating the apoptotic cascade. Diverse cytokine receptors and environmental stresses utilize ceramide to signal apoptosis. In several cell systems ceramide links to the stress-activated protein kinase (SAPK)/c-jun kinase (JNK) cascade to signal apoptosis. The engagement of the sphingomyelin pathway in signaling apoptosis is tightly regulated by anti-apoptotic control mechanisms, and the balance between pro- and anti-apoptotic systems determines the magnitude of the apoptotic response in vitro and in vivo. This review describes the known elements and molecular ordering of ceramide-mediated apoptosis and the anti-apoptotic mechanisms that regulate its expression. Understanding of pro- and anti-apoptotic signaling involved in ceramide-mediated apoptosis and the modes of their co-ordinated function may yield opportunities for pharmacological interventions with potential for clinical applications.

[sccrbrg]

That's really stretching it.

It hasn't even been confirmed that RLS deals in cannaboids - so far its just plant extracts which could be any number of things.

[matt]

It is important to understand precisely which plant extracts we are talking about. Eukaryotic cells vary widely and the cost and technical difficulty of extracting useful proteins from plant material is widely known, which is why almost all biotechnology production systems use mammalian cells, e. Coli, or yeast in their expression system. Without knowing the exact molecule it is impossible to conclude that TS is the ideal delivery system or even a feasible system for any particular drug.

The forests of the world have given us many useful medicaments (the principal ingredients of digitalis, aspirin, and many antibiotics for example) but the same forests have swallowed billions in investment dollars with no payoff (Shaman Pharmaceuticals for example). Tread carefully and with your eyes wide open; plants are not nearly as cooperative as bacteria.

[dreamboatcruise]

Hopefully it isn't something like that, because run ups in biopharma on dreams of as yet even in trial cannabis drugs tend to end in crashes.

Let's hope the increase is merely people realizing that the reward/risk profile of Afrezza as an investment had overshot to the downside.

[BlueCat]

With the lizard and scrrbg.

Sure, interesting connection could be a great business opportunity for RLS and MNKD in future depending results of trials that I'm guessing could take years.


But nothing anyone would buy stock on today, especially from a company which across market at moment, its considered a very high risk near term trade or investment - unless perhaps it was RLS itself as the buyer with a very long view and inside knowledge they were allowed to act on.


More like we've finally hit bottom (SNY ditch), or shorts are just setting up another bull trap til April 5 when they are hoping news will underwhelm at that time and can reintro their FUD.

[peppy]

Mar 16, 2016 11:28:36 GMT -5 BlueCat said:

With the lizard and scrrbg.

Sure, interesting connection could be a great business opportunity for RLS and MNKD in future depending results of trials that I'm guessing could take years.


But nothing anyone would buy stock on today, especially from a company which across market at moment, its considered a very high risk near term trade or investment - unless perhaps it was RLS itself as the buyer with a very long view and inside knowledge they were allowed to act on.


More like we've finally hit bottom (SNY ditch), or shorts are just setting up another bull trap til April 5 when they are hoping news will underwhelm at that time and can reintro their FUD.

Medical Marijuana: trials may not be involved.  For instance, Cannabidiol (CBD) in hemp oil is sold as a food product.
Just sayin.

[fofos2000i]

i found this federal program from U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS), THE NATIONAL INSTITUTES OF HEALTH (NIH) AND THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

NIH/NIDA 159 Therapeutic Cannabidiol Pulmonary Delivery Device

sbir.nih.gov/sites/default/files/PHS2016-1.pdf

Page 122 +

Objective

To develop a pulmonary delivery device that can administer therapeutic doses of the non-psychoactive cannabinoid
CBD. The ultimate goal is to generate a sufficiently characterized clinical tool such that the Food and Drug
Administration (FDA) would allow it to be used to evaluate the efficacy of inhaled CBD as a therapeutic agent in
clinical trials.

This opportunity is open to all Small Business Innovation Research (SBIR) award-eligible organizations. However,
it is ANTICIPATED that a Small Business Concern (SBC) best equipped to produce such a characterized device and data
package within the time and budget constraints MIGHT CURRENTLY be marketing a similar or related inhalation product

...

Background

CBD is a compound found in marijuana that has no euphoric properties but appears to have other pharmacological
activities. Current understanding of CBD pharmacology is limited; a number of laboratory studies have been
conducted and a few have progressed into early clinical phase investigations, the most successful demonstrating
CBD as an anxiolytic agent. Potential applications for the anxiolytic properties of CBD include reduction of craving
and relapse in Substance Use Disorders, and reduction of anxiety in Post-Traumatic Stress Disorder. In addition,
CBD is currently under clinical investigation for the treatment of childhood intractable epilepsies, where it is added
to the existing medication regimen (usually, to 2-3 other drugs). However, CBD is well known as an inactivator of
drug metabolizing enzymes and so can significantly disturb the patient’s exposure to their current medications and
potentially contribute to serious drug interactions. If CBD is to be administered via a pulmonary (inhaled)
mechanism rather than via oral route, the liver exposure would be much lower, resulting in less enzyme inactivation
and drug-drug interactions. Furthermore, inhaled CBD provides 2-3x greater bioavailability and shows substantially
lower inter-dose and inter-subject variability than with oral administration. when used in a clinical trial a pulmonary
delivery device would result in more reproducible CBD dosing, less risk of drug interactions and ultimately less
variable and more reproducible clinical data

i just wanted to add some information on CBD and the attention it gets recently !

[peppy]

Mar 21, 2016 7:24:40 GMT -5 fofos2000i said:

i found this federal program from U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS), THE NATIONAL INSTITUTES OF HEALTH (NIH) AND THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

NIH/NIDA 159 Therapeutic Cannabidiol Pulmonary Delivery Device

sbir.nih.gov/sites/default/files/PHS2016-1.pdf

Page 122 +

Objective

To develop a pulmonary delivery device that can administer therapeutic doses of the non-psychoactive cannabinoid
CBD. The ultimate goal is to generate a sufficiently characterized clinical tool such that the Food and Drug
Administration (FDA) would allow it to be used to evaluate the efficacy of inhaled CBD as a therapeutic agent in
clinical trials.

This opportunity is open to all Small Business Innovation Research (SBIR) award-eligible organizations. However,
it is ANTICIPATED that a Small Business Concern (SBC) best equipped to produce such a characterized device and data
package within the time and budget constraints MIGHT CURRENTLY be marketing a similar or related inhalation product

...

Background

CBD is a compound found in marijuana that has no euphoric properties but appears to have other pharmacological
activities. Current understanding of CBD pharmacology is limited; a number of laboratory studies have been
conducted and a few have progressed into early clinical phase investigations, the most successful demonstrating
CBD as an anxiolytic agent. Potential applications for the anxiolytic properties of CBD include reduction of craving
and relapse in Substance Use Disorders, and reduction of anxiety in Post-Traumatic Stress Disorder. In addition,
CBD is currently under clinical investigation for the treatment of childhood intractable epilepsies, where it is added
to the existing medication regimen (usually, to 2-3 other drugs). However, CBD is well known as an inactivator of
drug metabolizing enzymes and so can significantly disturb the patient’s exposure to their current medications and
potentially contribute to serious drug interactions. If CBD is to be administered via a pulmonary (inhaled)
mechanism rather than via oral route, the liver exposure would be much lower, resulting in less enzyme inactivation
and drug-drug interactions. Furthermore, inhaled CBD provides 2-3x greater bioavailability and shows substantially
lower inter-dose and inter-subject variability than with oral administration. when used in a clinical trial a pulmonary
delivery device would result in more reproducible CBD dosing, less risk of drug interactions and ultimately less
variable and more reproducible clinical data

i just wanted to add some information on CBD and the attention it gets recently !

collaborators in the USA listed. Bethesda. Aberdeen and Richmond.

screencast.com/t/pPR4pDKxR

And Israel

screencast.com/t/4zpsWatIJ

[mindovermatter]

Mar 21, 2016 7:53:35 GMT -5 peppy said:

Mar 21, 2016 7:24:40 GMT -5 fofos2000i said:

i found this federal program from U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS), THE NATIONAL INSTITUTES OF HEALTH (NIH) AND THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

NIH/NIDA 159 Therapeutic Cannabidiol Pulmonary Delivery Device

sbir.nih.gov/sites/default/files/PHS2016-1.pdf

Page 122 +

Objective

To develop a pulmonary delivery device that can administer therapeutic doses of the non-psychoactive cannabinoid
CBD. The ultimate goal is to generate a sufficiently characterized clinical tool such that the Food and Drug
Administration (FDA) would allow it to be used to evaluate the efficacy of inhaled CBD as a therapeutic agent in
clinical trials.

This opportunity is open to all Small Business Innovation Research (SBIR) award-eligible organizations. However,
it is ANTICIPATED that a Small Business Concern (SBC) best equipped to produce such a characterized device and data
package within the time and budget constraints MIGHT CURRENTLY be marketing a similar or related inhalation product

...

Background

CBD is a compound found in marijuana that has no euphoric properties but appears to have other pharmacological
activities. Current understanding of CBD pharmacology is limited; a number of laboratory studies have been
conducted and a few have progressed into early clinical phase investigations, the most successful demonstrating
CBD as an anxiolytic agent. Potential applications for the anxiolytic properties of CBD include reduction of craving
and relapse in Substance Use Disorders, and reduction of anxiety in Post-Traumatic Stress Disorder. In addition,
CBD is currently under clinical investigation for the treatment of childhood intractable epilepsies, where it is added
to the existing medication regimen (usually, to 2-3 other drugs). However, CBD is well known as an inactivator of
drug metabolizing enzymes and so can significantly disturb the patient’s exposure to their current medications and
potentially contribute to serious drug interactions. If CBD is to be administered via a pulmonary (inhaled)
mechanism rather than via oral route, the liver exposure would be much lower, resulting in less enzyme inactivation
and drug-drug interactions. Furthermore, inhaled CBD provides 2-3x greater bioavailability and shows substantially
lower inter-dose and inter-subject variability than with oral administration. when used in a clinical trial a pulmonary
delivery device would result in more reproducible CBD dosing, less risk of drug interactions and ultimately less
variable and more reproducible clinical data

i just wanted to add some information on CBD and the attention it gets recently !

collaborators in the USA listed. Bethesda. Aberdeen and Richmond.

screencast.com/t/pPR4pDKxR

And Israel

screencast.com/t/4zpsWatIJ

Is there any definitive proof that Mannkind is working on any of this? 

[peppy]

quote: Is there any definitive proof that Mannkind is working on any of this?

Reply: These are some of the most guarded secrets around, all this stuff.

and you ask if this cowdonk idiot has proof.

I say get your head out of the sand, and do your own work.

read around.

The economy has gotten oil out of rock with fracking. The world goes on.

[4allthemarbles]

Peppy- ouch. A little funny, but ouch.

[Deleted]

www.vice.com/tag/weediquette


If you want to learn about pot. Some of the medical uses are high lighted and the uphill battle faced for medical purposes.


The war on drugs is a huge business and drain on our tax paying dollars. IMO it holds back the medical positives of weed. Watch some of these episodes

[peppy]

Mar 21, 2016 16:18:49 GMT -5 @reverselo said:

www.vice.com/tag/weediquette


If you want to learn about pot. Some of the medical uses are high lighted and the uphill battle faced for medical purposes.


The war on drugs is a huge business and drain on our tax paying dollars. IMO it holds back the medical positives of weed. Watch some of these episodes

When I was a child the cold war was still going on.
On the nightly news, I used to hear words like propaganda.
The words used, told us, that was a system used in the USSR.
I believed it. Too stupid to know, I was listening to propaganda.

The history of marijuana goes back to biblical times.
The seeds were brought to this Continent, on Spanish ships, and British ships. They used it to make rope, sails and for paper. The first draft of the US constitution was written on hemp paper. The founding fathers grew it.
www.youtube.com/watch?v=v6OrMDLcCpY

The war on our own people has brought the police departments a lot of revenue.

screencast.com/t/04WuXGAW3jPR
I have pictures I can post of American military protecting afgan poppy fields.
This war on drugs is not what it seems.

screencast.com/t/OfQGR6PL

screencast.com/t/Dz5EmMsX7t