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Post by sweedee79 on Apr 3, 2016 22:24:54 GMT -5
This is 6 year old Charlotte Figi's story, aired on CNN
www.cnn.com/2013/08/07/health/charlotte-child-medical-marijuana/
One of the things that stands out to me beside the point that CBD can be a miracle drug for patients with dravet syndrome, is the fathers comments... " How come a doctor didn't know about this? How come they didn't make me aware of this?" .... It reminds me so much of Afrezza ... How many other amazing drugs and treatments end up in this quagmire of obstinance rather than getting to the patients that need it??? I believe that had Charlotte not been given CBD for her seizures when they did... she would have died..
I hope that this is what RLS is about... if it is I'm all for it... and if CBD is good for dravet syndrome and cancer treatment, what about other seizure disorders... ?? I lost a son 10 years ago who had cerebral palsy.. he also had grand mal type of seizures... so this story is dear to my heart.. The compounds in marijuana are far more than the THC that makes people high... |
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Post by peppy on Apr 3, 2016 22:37:03 GMT -5
This is 6 year old Charlotte Figi's story, aired on CNN
www.cnn.com/2013/08/07/health/charlotte-child-medical-marijuana/
One of the things that stands out to me beside the point that CBD can be a miracle drug for patients with dravet syndrome, is the fathers comments... " How come a doctor didn't know about this? How come they didn't make me aware of this?" .... It reminds me so much of Afrezza ... How many other amazing drugs and treatments end up in this quagmire of obstinance rather than getting to the patients that need it??? I believe that had Charlotte not been given CBD for her seizures when they did... she would have died..
I hope that this is what RLS is about... if it is I'm all for it... and if CBD is good for dravet syndrome and cancer treatment, what about other seizure disorders... ?? I lost a son 10 years ago who had cerebral palsy.. he also had grand mal type of seizures... so this story is dear to my heart.. The compounds in marijuana are far more than the THC that makes people high... And the other child, the boy. Looking sooooo much better than he looked on the pharmaceutical drugs. You can see he was in a corticosteroid (among other drugs) by his look. He can live now. www.youtube.com/watch?v=S9qkYLtAhSQ (it looks like technosphere gets to deliver. ) It will be clean, the video said charolettes web 5 thc to 50 cbd, in the unit of measurement. Epilepsy. I should add, it may be an oral, as the oral buffered, technosphere patent had CBD delivery. I will dig it up. I did not spot it on the quick, cbd is on the patent somewhere by memory. patents.justia.com/patent/9259471
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Post by sweedee79 on Apr 3, 2016 23:37:28 GMT -5
Great video peppy .. Thanks for all of the info you dig up.. interesting stuff.. |
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Post by peppy on Apr 6, 2016 10:55:14 GMT -5
Problem look out: The FDA will continue to facilitate the work of companies interested in appropriately bringing safe, effective, and quality products to market, including scientifically-based research concerning the medicinal uses of marijuana.
4. How does FDA’s role differ from NIH and DEA’s role when it comes to the investigation of marijuana for medical use?
A. Conducting clinical research using marijuana involves interactions with several federal agencies. This includes: a registration administered by the Drug Enforcement Administration (DEA); obtaining the marijuana for research from the National Institute on Drug Abuse (NIDA) within the National Institutes of Health; and review of an investigational new drug (IND) application and research protocol by the FDA. Additionally:
•As a Schedule I controlled substance under the Controlled Substances Act, DEA provides researchers with a special registration and has certain requirements at the site marijuana will be studied.
•NIDA provides research-grade marijuana for scientific study. The agency is responsible for overseeing the cultivation of marijuana for medical research and has contracted with the University of Mississippi to grow marijuana for research at a secure facility. Marijuana of varying strengths and potencies is available.
•Researchers work with the FDA and submit an IND application.
5. Does the FDA object to the clinical investigation of marijuana for medical use?
A. No. The FDA believes that scientifically valid research conducted under an IND application is the best way to determine what patients could benefit from the use of drugs derived from marijuana. The FDA supports the conduct of that research by:
1.Providing information on the process needed to conduct clinical research using marijuana.
2.Providing information on the specific requirements needed to develop a drug that is derived from a plant such as marijuana. In June 2004, the FDA finalized its Guidance for Industry: Botanical Drug Products, which provides sponsors with guidance on submitting IND applications for botanical drug products.
3.Providing specific support for investigators interested in conducting clinical research using marijuana and its constituents as a part of the IND process through meetings and regular interactions throughout the drug development process.
4.Providing general support to investigators to help them understand and follow the procedures to conduct clinical research through the FDA Center for Drug Evaluation and Research’s Small Business and Industry Assistance group. -------------------------------------------------------------------------------------------- obtaining the marijuana for research from the National Institute on Drug Abuse (NIDA) within the National Institutes of Health ***charolette's web is .05% THC 17% Cannabiniod. ------------------------------------------------------------------------------------------------------- 9. What is FDA’s reaction to states that are allowing marijuana to be sold for medical uses without the FDA’s approval?
A. The FDA is aware that several states have either passed laws that remove state restrictions on the medical use of marijuana and its derivatives or are considering doing so. In particular, we know that a number of states are interested in allowing access to cannabinoid oil, or cannabidiol, in an attempt to treat childhood epilepsy. It is important to conduct medical research into the safety and effectiveness of marijuana products through adequate and well-controlled clinical trials. We welcome the opportunity to talk with states who are considering support for medical research of marijuana and its derivatives to provide information on Federal and scientific standards. www.fda.gov/NewsEvents/PublicHealthFocus/ucm421168.htm
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Post by Deleted on Apr 6, 2016 11:03:53 GMT -5
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Post by matt on Apr 6, 2016 11:11:04 GMT -5
The big issue with banks, and in general, with regard to the topic IS that it is still illegal at the Federal level. That means FDIC, FDA, DEA, etc. IANAL, but I was taught that Federal trumps State by precedent.
The FDA has no issue with any particular molecule, including cannabinoids. Their concern over plant based marijuana and similar products is that there is no dose control unlike an approved pharmaceutical. Producing synthetic cannabinoids in the laboratory is not that difficult, and if there was a pharma company interested in those applications FDA would willingly give approval to produce the substance and run a clinical trial. However, such a product will have to comply with all the same regulatory hurdles as any other new drug and that is something that can never happen with the plant based material due to the costs and technical challenges associated with extracting and purifying the active ingredient.
Meanwhile, you are correct that federal law trumps state law. If the DEA had the resources and the willpower, they could shut down every medical marijuana dispensary in the country; whether or not that would be a wise action and an appropriate use of government resources it a political question best discussed elsewhere. |
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Post by peppy on Apr 6, 2016 11:14:40 GMT -5
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Post by peppy on Apr 6, 2016 11:41:08 GMT -5
The big issue with banks, and in general, with regard to the topic IS that it is still illegal at the Federal level. That means FDIC, FDA, DEA, etc. IANAL, but I was taught that Federal trumps State by precedent.
The FDA has no issue with any particular molecule, including cannabinoids. Their concern over plant based marijuana and similar products is that there is no dose control unlike an approved pharmaceutical. Producing synthetic cannabinoids in the laboratory is not that difficult, and if there was a pharma company interested in those applications FDA would willingly give approval to produce the substance and run a clinical trial. However, such a product will have to comply with all the same regulatory hurdles as any other new drug and that is something that can never happen with the plant based material due to the costs and technical challenges associated with extracting and purifying the active ingredient.
Meanwhile, you are correct that federal law trumps state law. If the DEA had the resources and the willpower, they could shut down every medical marijuana dispensary in the country; whether or not that would be a wise action and an appropriate use of government resources it a political question best discussed elsewhere. good point, screencast.com/t/HA1bAqbeoZ www.slate.com/content/dam/slate/articles/news_and_politics/politics/2014/08/140813_POL_FergusonCops2.jpg.CROP.promovar-mediumlarge.jpg all-that-is-interesting.com/wordpress/wp-content/uploads/2014/08/ferguson-dont-shoot.jpg screencast.com/t/yQBe9tq31g screencast.com/t/ozvzROD8yO so 60's it reminds me of the song, 1,2,3 what are we fighting for? screencast.com/t/cUzTsOmbr0B if true that should get a rise of attention. screencast.com/t/CDJFQeg23
Country Joe Mcdonald at Woodstock www.youtube.com/watch?v=nXspsfoPX50
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Post by longinvstr on Apr 6, 2016 12:16:31 GMT -5
Thank you, Peppy, for the links! Eye opening is right I do have a much higher (  ) regard for cannabinoid potential. There is more we don't than that we do but very encouraging early developments. As a corollary, I'm leaning harder your way to the future role TS and RLS may play For the record tho, I LOVE my prostate |
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Post by lakon on Apr 6, 2016 14:33:04 GMT -5
The big issue with banks, and in general, with regard to the topic IS that it is still illegal at the Federal level. That means FDIC, FDA, DEA, etc. IANAL, but I was taught that Federal trumps State by precedent.
The FDA has no issue with any particular molecule, including cannabinoids. Their concern over plant based marijuana and similar products is that there is no dose control unlike an approved pharmaceutical. Producing synthetic cannabinoids in the laboratory is not that difficult, and if there was a pharma company interested in those applications FDA would willingly give approval to produce the substance and run a clinical trial. However, such a product will have to comply with all the same regulatory hurdles as any other new drug and that is something that can never happen with the plant based material due to the costs and technical challenges associated with extracting and purifying the active ingredient.
Meanwhile, you are correct that federal law trumps state law. If the DEA had the resources and the willpower, they could shut down every medical marijuana dispensary in the country; whether or not that would be a wise action and an appropriate use of government resources it a political question best discussed elsewhere. Personally, I think that the FDA has a lot of issues. Molecules are but a small part. **pun** Willful ignorance and naivete of the populace being the primary issue at cause, but I digress. I agree that it seems a path forward has opened at the FDA, but it is just a crack so far. I thought that GWPH had a distinct advantage because of our illicit drug schedules. Perhaps, it has a chink in its armor. I seem to be full of puns today. |
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Post by peppy on Apr 6, 2016 14:38:02 GMT -5
The FDA has no issue with any particular molecule, including cannabinoids. Their concern over plant based marijuana and similar products is that there is no dose control unlike an approved pharmaceutical. Producing synthetic cannabinoids in the laboratory is not that difficult, and if there was a pharma company interested in those applications FDA would willingly give approval to produce the substance and run a clinical trial. However, such a product will have to comply with all the same regulatory hurdles as any other new drug and that is something that can never happen with the plant based material due to the costs and technical challenges associated with extracting and purifying the active ingredient.
Meanwhile, you are correct that federal law trumps state law. If the DEA had the resources and the willpower, they could shut down every medical marijuana dispensary in the country; whether or not that would be a wise action and an appropriate use of government resources it a political question best discussed elsewhere. Personally, I think that the FDA has a lot of issues. Molecules are but a small part. **pun** Willful ignorance and naivete of the populace being the primary issue at cause, but I digress. I agree that it seems a path forward has opened at the FDA, but it is just a crack so far. I thought that GWPH had a distinct advantage because of our illicit drug schedules. Perhaps, it has a chink in its armor. I seem to be full of puns today. they seem to want to work with synthetics. Israel has a synthetic cannabinoid in trials. Israel the first synthetic didn't work, they have reworked it. enough said I guess.
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Post by sportsrancho on Apr 7, 2016 21:22:56 GMT -5
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Post by blindhog1 on Apr 7, 2016 21:45:14 GMT -5
Oh Yeah...now that's 2 dedicated Nun's. But we know smoking isn't good for you.
Reminds me a lot of Carlos Castaneda and Don Juan Matus with their magic mushrooms. Go on a trip and never leave the room. Edibles are the way to go with THC Oil. I think I prefer 4 unit chocolate bars. But peanut butter and mushroom sandwiches (on Rye Bread) with a little honey really is tempting.
What is it we were going to cure? 
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Post by peppy on Apr 8, 2016 4:41:51 GMT -5
Oh Yeah...now that's 2 dedicated Nun's. But we know smoking isn't good for you.
Reminds me a lot of Carlos Castaneda and Don Juan Matus with their magic mushrooms. Go on a trip and never leave the room. Edibles are the way to go with THC Oil. I think I prefer 4 unit chocolate bars. But peanut butter and mushroom sandwiches (on Rye Bread) with a little honey really is tempting.
What is it we were going to cure?
I wouldn't touch an edible with a ten foot pole. Although I have seen pictures of edible hard candies which may change the absorption/time issues
The non-Catholic nuns, are making oil. 1 ounce marijuana, 1 cup everclear or other alcohol solvent, stir well, allow to sit 10 mins, stir, drain through cheese cloth, keeping both the cannabis and alcohol. repeat x 1 boil down the everclear in a double boiler. capture the oil. the oil has been used to heal topically. screencast.com/t/PZEiMuOqxjM screencast.com/t/yYrU7mqfm
(I had to look to see what was being done.)
screencast.com/t/ozvzROD8yO screencast.com/t/yQBe9tq31g
Epilepsy seems to be one use that will be easy to verify in a clinical study. The testimonials, 300 seizures a week down to 1 seizure a week. Perhaps any clinical study would be ended early because end points are met?
Neuron Resting Potential www.youtube.com/watch?v=YP_P6bYvEjE
I see you know enough about the subject to see how it may actually work. Think about autism, not the pretend autism, real autism.
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Post by peppy on May 23, 2016 13:18:17 GMT -5
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) regard for cannabinoid potential. There is more we don't than that we do but very encouraging early developments. As a corollary, I'm leaning harder your way to the future role TS and RLS may play
