Mannkind Oral Insulin

[patten1962]

I did a pro board search and couldn't find it. I believe Holdem talked about this one time. Does anyone know if Mannkind is working on a Oral Insulin?

[mnholdem]

You are referring to a recent update of a patent awarded to MannKind, but the origination date is long enough ago that I don't believe it's being developed by the company.

[cm5]

See Peppy's post 6 March 2016


Oral Administration of Disodium FDKP-Insulin

Capsules containing the FDKP salt and insulin are taken before a meal. The exact dosage is patient-specific, but generally on the order of 10-150 units of insulin is administered per dose.



This oral insulin formulation is used to replace pre-meal insulin injections in patients with diabetes. Additionally, insulin absorbed through the gastrointestinal tract mimics endogenous insulin secretion. Endogenous insulin is secreted by the pancreas into the portal circulation. Thus, the oral route of insulin administration delivers insulin to the site of action in the liver, offering the potential to control glucose levels while limiting systemic exposure to insulin.



Oral insulin delivery using a combination of insulin and the diacid form of FDKP is hindered by the poor solubility of the FDKP diacid in the low PH environment of the gastrointestinal tract. The FDKP salts, however, provide a local buffering effect that facilitates their dissolution in low PH.





Read more: mnkd.proboards.com/thread/5250/mannkind-got-oral-insulin-patent?page=1#ixzz42Aw7eeYk

[cm5]

Feb 28, 2016 19:23:30 GMT -4 mnholdem said:

patents.justia.com/patent/9259471





Example 11



Oral Administration of Disodium FDKP-Insulin



Capsules containing the FDKP salt and insulin are taken before a meal. The exact dosage is patient-specific, but generally on the order of 10-150 units of insulin is administered per dose.



This oral insulin formulation is used to replace pre-meal insulin injections in patients with diabetes. Additionally, insulin absorbed through the gastrointestinal tract mimics endogenous insulin secretion. Endogenous insulin is secreted by the pancreas into the portal circulation. Thus, the oral route of insulin administration delivers insulin to the site of action in the liver, offering the potential to control glucose levels while limiting systemic exposure to insulin.



Oral insulin delivery using a combination of insulin and the diacid form of FDKP is hindered by the poor solubility of the FDKP diacid in the low PH environment of the gastrointestinal tract. The FDKP salts, however, provide a local buffering effect that facilitates their dissolution in low PH.



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There is more, but this could be BIG NEWS to shareholders. Date of patent: February 16, 2016 Filed:January 8, 2014



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Note: Andrea Leone-Bay is listed as one of three inventors.

[patten1962]

Thank you. I was cautious posting this. I did search it first could not find.

I was trying to think as a healthcare professional what would be epic for mankind? One of the things that came to my head was some type of insulin that would be long-acting to go along with Afrezza! When I remember you guys posting about this and it just made me curious. I'm only thinking out of the box I have no information and I am not pumping. Thank you for all your answers.

[cm5]

Thank You for The Thank You.

I seem a "newbie", finally joined last year when everything seemed dire, have rarely posted, but have been watching/reading for a very long time---years.

Patient is a strength and a virtue, as well as mandatory when waiting for disruptive technology to emerge.

I am an MD, not in primary care nor an endocrinologist, but I diagnose and care for the consequences of pre-diabetes and undiagnosed diabetes, as well as untreated elevated HgbA1c levels. Daily I am concerned and upset about what I see happening to my patients.

I remain convinced that Alfred Mann is the genius of our time, and that his efforts will lead to amazing improvements in the health of people worldwide----whether it be sooner or later than we all expect. 

[peppy]

Apr 17, 2016 17:13:19 GMT -5 patten1962 said:

Thank you. I was cautious posting this. I did search it first could not find.

I was trying to think as a healthcare professional what would be epic for mankind? One of the things that came to my head was some type of insulin that would be long-acting to go along with Afrezza! When I remember you guys posting about this and it just made me curious. I'm only thinking out of the box I have no information and I am not pumping. Thank you for all your answers.

The initial thread:

patents.justia.com/patent/9259471

Example 11

Oral Administration of Disodium FDKP-Insulin

Read more: mnkd.proboards.com/thread/5250/mannkind-got-oral-insulin-patent#ixzz468ZCg7LT