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Post by anderson on Apr 24, 2016 23:46:29 GMT -5
Again, off the cuff, I think that the inhaled epi has great appeal and would turn out to be the main thing most carry after they have been used for some time and proven to work. One of the big advantages of the inhaled version is that people would use it a lot more than a needle, as a protective measure or whenever they think they might have ingested a potential allergent. It would be a far better way to protect because it eliminates the undesired injection that might not be needed. I would venture a guess that the inhaled version would be used as much as 10 times more than the injectable version once its benefits are known and understood. Is there any medical basis to support your opinion? Is it really safe or wise to take epinephrine just as a protective measure? Or to dose yourself 10 times more than necessary? I've no idea, but I have my doubts. I have to say if I am going to carry just one device, I would carry the pen to be safe. Because someone else can always inject me, or I can still inject myself, on those occasions an attack is causing breathing difficulties that would prevent inhaled epi from being used. mnkdfann do you know what epinephrine is? Form wiki: Epinephrine, also known as adrenalin ....so if riding a roller coaster would put you in risk, yes dont take it. At the proper dose it should just be an adrenalin high. |
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Post by lakon on Apr 25, 2016 10:05:11 GMT -5
Technosphere is not only a carrier molecule, but also a stabilizer. Stabilizing other molecules is an important untapped market opportunity for improved storage, distribution, shelf life, and reconstitution without other preservatives that can be toxic, carcinogenic, and/or have other harmful side effects. In the case of Epinephrine, Technosphere could be helpful in a manner similar to the following patent application for Epinephrine-based ophthalmic compositions for intraocular administration. I referenced this patent before, but did not have time to explain its importance. It seems to me that MNKD already has patents that cover a lot of similar territory with perhaps the exception of an explicit mentioning of ophthalmological treatments. Nevertheless, MNKD could provide a stable dry powder composition with procedures/devices to reconstitute for different applications, such as the obvious inhalation and not so obvious IV, IM, Sub-Q, IO, etc. In general, the same methods could apply to many API. Therefore, Technosphere is much more than just an inhalation technology as other patents have disclosed; however, it is interesting to note that Epi is an API where this fact could easily be demonstrated in the market. Again, I think that the Epi maneuver is brilliant. The unmet medical needs go well beyond anaphylaxis. www.google.com/patents/WO2015051264A1?cl=enFrom the patent application by Imprimis Pharmaceuticals, Inc. ( imprimispharma.com/): " Epinephrine (EPI or epi) is a drug that is frequently used in ophthalmological treatments, procedures and surgeries, e.g., cataract surgery or glaucoma surgery. Epinephrine is known to be used for such purposes either alone or as an active ingredient in a composition, e.g., in intracameral epi-Shugarcaine for intraoperative floppy iris syndrome (IFIS) and pupil dilation. Epinephrine is a perishable product with limited shelf life and limited stability. Epinephrine quite easily gets oxidized to form adrenochrome (chemically, catecholamine quinone). The oxidation causes deactivation of epinephrine and the concomitant loss of its valuable medicinal properties. Therefore, most commercially available epinephrine contains preservatives and stabilizers, typically bisulfites, for a prolonged shelf life and stability. However, using epinephrine with preservatives is undesirable as it can cause toxicity in the eye, putting patients at risk for toxic anterior segment syndrome (TASS), an acute inflammation of the anterior segment. Although most TASS cases are cured with topical steroids, severe cases can lead to cornea transplantation and iris atrophy. Having alternative non-toxic epinephrine-based compositions and procedures utilizing them that are safer but equally effective is, therefore, desirable." |
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Post by lakon on Apr 25, 2016 10:21:05 GMT -5
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Post by lakon on Apr 25, 2016 10:26:42 GMT -5
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Post by lakon on Apr 25, 2016 11:57:38 GMT -5
Amphastar Connections Amphastar’s subsidiary, International Medication System, Ltd. (IMS), utilizes the proprietary prefilled disposable emergency syringes for crash cart use. Emergency syringes are provided in the Luer-Jet™; a completely needleless, Luer Lock syringe. Luer-Jet™ complies with OSHA's Needlestick Safety and Prevention Act, and is compatible with most Luer Activated Systems (including ICU Medical Clave® Valve). • Atropine Sulfate Injection, USP • Calcium Chloride Injection, USP • Dextrose Injection, USP • Epinephrine Injection, USP • Lidocaine HCI Injection, USP • Sodium Bicarbonate Injection, USP www.amphastar.com/our-products.html |
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Post by Deleted on Jul 20, 2016 22:43:38 GMT -5
There are so many drugs that could be greatly improved via Technosphere. For people to downplay inhaling Epi as an alternative, or even superior alternative actually, might have forgotten about how any severity of an asthma attack is treated. The way Technosphere actually works is far, far beyond the way today's MDIs and DPIs and nebulizers work. I am sure MannKind would make their version of inhaled Epi with all the advantages we currently see with Afrezza and probably even better. When I look at our EpiPen in the cabinet (cabinet=EpiPen is a inconvenience to have and carry), not to mention I cringe in the thought of having to jab that thing in me. People don't accept user-friendly devices/ideas at first because they have been stuck with an accepted inconvenience that they have managed their lives around. Afrezza is starting to wake some people up to the notion that needles don't HAVE to be the only way and that there actually is a better and easier way to help manage their chronic condition.
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Post by saxcmann on Aug 2, 2016 19:54:35 GMT -5
I believe Lakon is correct... Technosphere+Epinephrine is coming. Would this be epic?? Not sure but timeline is getting close for possible news or update from mnkd. Thoughts?
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Post by audiomr on Aug 3, 2016 15:58:17 GMT -5
I believe Lakon is correct... Technosphere+Epinephrine is coming. Would this be epic?? Not sure but timeline is getting close for possible news or update from mnkd. Thoughts? Probably will say something about progress during earnings call. |
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Post by Deleted on Aug 3, 2016 18:29:59 GMT -5
I think a Technosphere-Epinephrine would be extremely beneficial and handy to have around. I would guess MannKind would try to also make it heat-stable. Imagine just tossing the inhaler in your car and 3 months later you are driving down the road and start to notice symptoms of anaphylaxis. Or you are out camping and the closest hospital is an hour away. You have 3 Epi-inhalers stashed in your car because they are heat-stable and cheap. You develop symptoms of anaphylaxis.
I also think that MannKind and TechnoVax could make an extremely reliable and beneficial peanut allergy vaccine. Using TechnoVax's VLP technology coupled with MannKind's Techosphere and inhaler technology, it could harness amazing potential.
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Post by Deleted on Aug 3, 2016 18:36:36 GMT -5
I have also thought that if MannKind were to make a Technosphere-Epinephrine that they should make, in addition to prefilled inhaler, a blister package similar to Afrezza, yet also able to be opened up and poured directly in the mouth or in a cup of water or a drink.
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Post by Deleted on Aug 3, 2016 19:25:12 GMT -5
I have also thought that if MannKind were to make a Technosphere-Epinephrine that they should make, in addition to prefilled inhaler, a blister package similar to Afrezza, yet also able to be opened up and poured directly in the mouth or in a cup of water or a drink. What? Do u think it's alkaseltzer? To be poured directly or in a cup of water to drink.. Please... Hakan would be interested to talk to you |
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Post by comnkd on Aug 3, 2016 19:38:03 GMT -5
I have also thought that if MannKind were to make a Technosphere-Epinephrine that they should make, in addition to prefilled inhaler, a blister package similar to Afrezza, yet also able to be opened up and poured directly in the mouth or in a cup of water or a drink. You just jumped the shark. |
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Post by Deleted on Aug 3, 2016 20:09:51 GMT -5
I have also thought that if MannKind were to make a Technosphere-Epinephrine that they should make, in addition to prefilled inhaler, a blister package similar to Afrezza, yet also able to be opened up and poured directly in the mouth or in a cup of water or a drink. What? Do u think it's alkaseltzer? To be poured directly or in a cup of water to drink.. Please... Hakan would be interested to talk to you Epi is put down an ETT all the time. If I were deep in the woods and a friend was about to code, yeah, I'd pour an Epi powder down his throat. Edited to say, before someone corrects me—I already know it gets broken down in the stomach and doesn't work. There has never been an Epi than can be taken that way, but how do you know that problem can't be fixed? |
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Post by Deleted on Aug 3, 2016 20:17:13 GMT -5
I have also thought that if MannKind were to make a Technosphere-Epinephrine that they should make, in addition to prefilled inhaler, a blister package similar to Afrezza, yet also able to be opened up and poured directly in the mouth or in a cup of water or a drink. You just jumped the shark. How do you know it can't be made to be effective that way? |
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Post by Deleted on Aug 3, 2016 20:47:00 GMT -5
I just looked and there are studies on sublingual administration of Epinephrine that show postive results. So, yeah, I would guess that a MannKind version would produce effects if I put the powder under my tongue.
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