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Curing T2d
Apr 24, 2016 18:31:58 GMT -5
via mobile
Post by uvula on Apr 24, 2016 18:31:58 GMT -5
The current theory is that once you have full blown T2d is is not curable. Is it possible that a brand new T2D could be cured if they were started on insulin right away instead of the current "let's try these first" medicines? Have there been any studies to prove or disprove this?
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Post by mbseeking on Apr 24, 2016 19:01:06 GMT -5
Seems to me what is truly known about this disease is very little , and any treatment update seems to lag by 20 years. My reading suggests insulin is the 'final' response in current treatment thinking. But I can guess where you are going with this.. if the insulin is easy , why not early? I also recall comments attributed to Al Mann on this.. that the Afrezza puff at the meal essentially shuts down the liver from making glucose - which is a major part of the T2 problem. Studies. Seems to be an immensely fertile ground for studies with Afrezza. T2s, pre-diabetics - I can mentally construct many studies to test if applying insulin much earlier changes the progression. Unlikely MNKD would ever run these.. even if they turn out commercially successful. They have many more basic and expensive studies to conclude/ start to get a decent label. Would need to come out of the medical / university community. Time will tell. A researcher trying to make a name for themselves may yet do it. And who knows.. Afrezza may not be the only possible answer. For those who have complete diet discipline: well.blogs.nytimes.com/2016/04/18/hope-for-reversing-type-2-diabetes/?hpw&rref=health&action=click&pgtype=Homepage&module=well-region®ion=bottom-well&WT.nav=bottom-well&_r=0 |
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Curing T2d
Apr 24, 2016 21:45:20 GMT -5
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Post by tayl5 on Apr 24, 2016 21:45:20 GMT -5
A substantial part of the current Tom Hanks thread is focused on ways of reversing T2D.
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Post by uvula on Apr 25, 2016 1:17:20 GMT -5
A substantial part of the current Tom Hanks thread is focused on ways of reversing T2D. That thread is focused on long time t2ds. My thread is focused on brand new t2ds and the possibility that reversing new t2ds could be different than reversing long time t2ds. |
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Post by prosper on Apr 25, 2016 7:23:12 GMT -5
One of the greatest minds alive today is Ray Kurzweil. His accomplishments are too numerous to list here, but if you Google him you will be amazed
He cured himself of T2 diabetes as chronicled in his book "Fantastic Voyage--How to live long enough to live forever (subtitle) No, it is not the Raquel Welch mini-sub in the blood stream.
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Post by matt on Apr 25, 2016 8:30:22 GMT -5
Attempts to reverse T2D are focused on making the body more insulin sensitive. Type 1 diabetics have a problem because their bodies fail to produce enough insulin (pancreatic beta islet cells die or become incompetent for various reasons), but Type II diabetics often produce plenty of insulin but their bodies do not respond normally to the insulin that is produced. This is often referred to as a lack of "insulin sensitivity". Over time the Type II body produces more and more insulin in an attempt to offset the lack of sensitivity, but that can in turn exhaust the islet cells and at that point the patient may need supplemental insulin.
The principal causes of Type II are genetic and life-style related. Obviously you cannot change your genetic composition, but you can change your diet and exercise regimen and, if you do, your sensitivity to insulin will change accordingly. The question of whether an new versus old Type II can be reversed depends on a host of factors including the residual level of insulin production and, most importantly, the motivation of the patient to change their diet and level of exercise. It is not reversible for everyone, but many can reverse the disease or at least lessen the severity. Given the complexity of diabetes, advice on whether a particular patient can mitigate existing disease is a topic more suitable to discuss with a physician following a comprehensive work up rather than a message board discussion.
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Post by mnholdem on Apr 25, 2016 8:42:03 GMT -5
The current theory is that once you have full blown T2d is is not curable. Is it possible that a brand new T2D could be cured if they were started on insulin right away instead of the current "let's try these first" medicines? Have there been any studies to prove or disprove this? I created a thread entirely devoted to this subject. It's posted within the Articles folder:
mnkd.proboards.com/thread/3788/experts-convened-discuss-intensive-insulin
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Post by lakon on Apr 25, 2016 11:26:11 GMT -5
The current theory is that once you have full blown T2d is is not curable. Is it possible that a brand new T2D could be cured if they were started on insulin right away instead of the current "let's try these first" medicines? Have there been any studies to prove or disprove this? I created a thread entirely devoted to this subject. It's posted within the Articles folder:
mnkd.proboards.com/thread/3788/experts-convened-discuss-intensive-insulin
The short answer is that Afrezza was needed to make the studies feasible within ethical safety limitations. There has been talk for a long time. Now is the time to start the studies to see IF short-term intensive insulin therapy at diagnosis in type 2 diabetes reverses a statistically relevant number of cases. I bet that it will. If it does, I bet that the same hypothesis applies to some other similar hormone treatable diseases. The results could be very important beyond imagination. Time will tell. |
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Post by lakon on May 3, 2016 13:33:40 GMT -5
The other question to consider is if it works at diagnosis, does it always work? Yes, the prevailing "wisdom" says no, but nobody has looked at it long enough. It takes something like 120 days for red blood cells to replenish. It takes something like a year or so for a liver to heal. Various other "spontaneous" corrections in the body take months or years, like floaters disappearing in the eye, venous injuries, etc. My point is that it might take a long time to correct after the stresser is removed, depending on the extent of the damage. If it takes on the order of years, nobody would notice for a while...
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Post by mnholdem on May 3, 2016 13:59:20 GMT -5
The short answer is that Afrezza was needed to make the studies feasible within ethical safety limitations. There has been talk for a long time. Now is the time to start the studies to see IF short-term intensive insulin therapy at diagnosis in type 2 diabetes reverses a statistically relevant number of cases. I bet that it will. If it does, I bet that the same hypothesis applies to some other similar hormone treatable diseases. The results could be very important beyond imagination. Time will tell. A few months ago, I forwarded basically the same message (with much additional reports and information) to CMO Dr. Urbanski and CEO Matt Pfeffer. I even ran the idea of sponsoring a STII with Afrezza by the CEO and Chairman of the Board at Takeda, since the experts that had convened to review STII studies were mostly from Asia. At the time I was attempting to convince them to take a close look at partnering with MannKind for distribution of Afrezza throughout their region.
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