Sanofi/Medivation

[kbrion77]

Things seem to be getting interesting here.


www.cnbc.com/2016/05/13/sanofi-to-nominate-8-people-to-replace-medivation-board.html

Looks like they have added our friends from GS as part of the advisory team as well.  This is cutthroat business at its finest.

[agedhippie]

May 13, 2016 13:37:14 GMT -5 kbrion77 said:

Things seem to be getting interesting here.


www.cnbc.com/2016/05/13/sanofi-to-nominate-8-people-to-replace-medivation-board.html

Looks like they have added our friends from GS as part of the advisory team as well.  This is cutthroat business at its finest.

Think of it as protection money - if GS are part of the team then the opposition cannot hire them to fight you. Standard Operating Procedure in these circumstances. A smart move by Sanofi to replace the board though because I think this could go to a bidding war.

[peppy]

May 13, 2016 13:37:14 GMT -5 kbrion77 said:

Things seem to be getting interesting here.


www.cnbc.com/2016/05/13/sanofi-to-nominate-8-people-to-replace-medivation-board.html

Looks like they have added our friends from GS as part of the advisory team as well.  This is cutthroat business at its finest.

Medivation = Medivation, known for its prostate cancer drug Xtandi, has also reportedly been approached by pharma giant Pfizer.

That is where the money is now, cancer.

Sanofi CEO plan is to chase the money trail.

Get the remainder of any money on peoples way out the door. 

Fear the best tactic. Like a ransom of sorts.

[cm5]

In 2012 (the most recent year numbers are available)—

177,489 men in the United States were diagnosed with prostate cancer.*†

27,244 men in the United States died from prostate cancer.*†

*Incidence counts cover about 99% of the U.S. population; death counts cover about 100% of the U.S. population. Use caution when comparing incidence and death counts.



†Source: U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2012 Incidence and Mortality Web-based Report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute; 2015.

Ph.D., R.D., director of CDC’s Division of Diabetes Translation. “Diabetes is costly in both human and economic terms. It’s urgent that we take swift action to effectively treat and prevent this serious disease.”


Key findings from the National Diabetes Statistics Report, 2014 (based on health data from 2012), include:


29 million people in the United States (9.3 percent) have diabetes.

1.7 million people aged 20 years or older were newly diagnosed with diabetes in 2012.

Non-Hispanic black, Hispanic, and American Indian/Alaska Native adults are about twice as likely to have diagnosed diabetes as non-Hispanic white adults.

208,000 people younger than 20 years have been diagnosed with diabetes (type 1 or type 2).

86 million adults aged 20 years and older have prediabetes.

The percentage of U.S. adults with prediabetes is similar for non-Hispanic whites (35 percent), non-Hispanic blacks (39 percent), and Hispanics (38 percent).

Diabetes is a serious disease that can be managed through physical activity, diet, and appropriate use of insulin and oral medications to lower blood sugar levels. Another important part of diabetes management is reducing other cardiovascular disease risk factors, such as high blood pressure, high cholesterol and tobacco use.

People with diabetes are at increased risk of serious health complications including vision loss, heart disease, stroke, kidney failure, amputation of toes, feet or legs, and premature death.

In 2012, diabetes and its related complications accounted for $245 billion in total medical costs and lost work and wages. This figure is up from $174 billion in 2007.


www.cdc.gov/features/diabetesfactsheet/

[cm5]

   Apples and Oranges, Costs and Values---A View from Afar---

   AFFIRM Phase III clinical trial of the drug Enzalutamide (Xtandi)show the drug extends life by an average five months in the most advanced stages of prostate cancer.

   Enzalutamide in Prostate Cancer after Chemotherapy

   N Engl J Med 2012; 367:2448-2449 December 20, 2012DOI: 10.1056/NEJMc1212940

The estimated life expectancy of men at age of 55 years with type 2 diabetes, 5 years after diagnosis, varies between 13.2 years for a patient who smokes, has systolic blood pressure of 180 mmHg, a total:HDL cholesterol ratio of 8, and HbA1c of 10%, and 21.1 years for a non-smoker with SBP of 120 mmHg, total/HDL ratio of 4, and HbA1c of 6%.



The increased risk of cardiovascular disease among people with type 2 diabetes is well understood and is increasingly recognized as one of the major hazards of type 2 diabetes. Cardiovascular disease is responsible for ∼70% of all mortality among patients with type 2 diabetes and is also a major contributor to diabetes-related healthcare costs.

Eur Heart J. 2009 Apr; 30(7): 834–839.

Published online 2008 Dec 24. doi: 10.1093/eurheartj/ehn567

[peppy]

prostate cancer; Overall, PCa is associated with a high economic burden in the USA; the total cost of care was estimated at about US$12 billion in 2010 (up from US$10 billion in 2006), ranking PCa as the fifth highest cancer in terms of national expenditures.[8,9

Diabetes; People with diagnosed diabetes incur average medical expenditures of about $13,700 per year, of which about $7,900 is attributed to diabetes.

Quicker money over time. Higher insurance payment.

I think it is all about money.

divide that 12 billion into your number; 177,489.

(A false number) but the money is in cancer, the collection plate.

www.medscape.com/viewarticle/840143

www.google.com/search?site=&source=hp&q=diabetes+cost+of+care&oq=diabetes+cost+of&gs_l=hp.1.0.0j0i20j0i22i30l8.1174.8194.0.10457.17.17.0.0.0.0.149.1698.10j7.17.0....0...1c.1.64.hp..0.16.1607.0..35i39j0i131j0i155i3j0i67j0i10.VpCJ6mhttNQ

[cm5]

People diagnosed with diabetes at age 40 years spent $124,600 more ($211,400 if not discounted) than their counterparts without diabetes over their remaining lifetime. For people diagnosed with diabetes at age 50 years, the discounted lifetime excess medical spending was $91,200 ($135,600 if not discounted); for those diagnosed at age 60 years, it was $53,800 ($70,200); and for those diagnosed at age 65 years, it was $35,900 ($43,900). Excess lifetime medical spending due to diabetes for women was higher than that for men. Regardless of age at diagnosis, people with diabetes spent considerably more on health care after age 65 years than their nondiabetic counterparts. Health care spending attributed to diabetes after age 65 years ranged from $23,900 to $40,900, depending on sex and age at diagnosis.

Over the past three decades, the number of Americans with diagnosed diabetes has more than tripled, from 6 million in 1980 to 21 million in 2010 (25). Given the current size of the U.S. population with diabetes, coupled with more than 79 million people with prediabetes who are at a high risk of developing type 2 diabetes (26), our lifetime cost estimates suggest that medical spending associated with diabetes will add an enormous burden to health care costs and will persist for at least the next several decades. For example, in 2011 nearly 150,000 Americans were diagnosed with diabetes between the ages of 65 and 69 years (27). Based on our estimates, this cohort of patients with newly diagnosed diabetes alone would be expected to add $4.6 billion to future medical spending, the majority of which would be paid by Medicare. Without effective diabetes prevention, increased medical spending due to diabetes will have a major fiscal impact on Medicare. As Thorpe and colleagues (28) suggested, the increasing prevalence of diabetes has been one of the leading causes of the growth in Medicare spending.

Age at diagnosis (years) by sex:       40
Years with diagnosed diabetes :        34
Life-years lost because of diabetes:   6.7
Undiscounted lifetime incremental spending (SD):  $211,400 

The Lifetime Cost of Diabetes and Its Implications for Diabetes Prevention:  Diabetes Care 2014 Sep; 37(9): 2557-2564. dx.doi.org/10.2337/dc13-2484

 So, $140,000 to $211,400 over 34 years of life (for diagnosis, both sexes, age 40) vs
 20,000 (2015 cases receiving course of Xtandi) x ave cost treatment course (less than 1 year) of $129,000.

 Or---Lots of dollars over many years into many pockets-------vs. ---------Lots of dollars over less than a year into a few pockets-------