Victoza does not help severe heart failure

[cm5]

But the new study found that over six months, patients had no better outcomes on liraglutide than on a placebo. Overall, about 38 percent were rehospitalized because their hearts were so weak, and 12 percent died. Indicators of heart failure such as breathlessness, difficulty walking, and a telltale blood protein did not improve in either group.



Almost 60 percent of these heart-failure patients also had diabetes. None had taken liraglutide before enrolling in the study. For the 91 who were put on liraglutide, outcomes including declining kidney function and rehospitalization were slightly worse than with a placebo, although it was not statistically significant, meaning it could be coincidental.



Lead author Kenneth B. Margulies, a heart-failure and transplant cardiologist at Penn, said diabetics with severe heart failure who are doing well on liraglutide should not quit the drug - but he wouldn't put them on it.

www.philly.com/philly/health/diabetes/20160803_Popular_diabetes_drug_Victoza_does_not_help_severe_heart_failure.html

[peppy]

Aug 3, 2016 4:36:10 GMT -5 cm5 said:

But the new study found that over six months, patients had no better outcomes on liraglutide than on a placebo. Overall, about 38 percent were rehospitalized because their hearts were so weak, and 12 percent died. Indicators of heart failure such as breathlessness, difficulty walking, and a telltale blood protein did not improve in either group.



Almost 60 percent of these heart-failure patients also had diabetes. None had taken liraglutide before enrolling in the study. For the 91 who were put on liraglutide, outcomes including declining kidney function and rehospitalization were slightly worse than with a placebo, although it was not statistically significant, meaning it could be coincidental.



Lead author Kenneth B. Margulies, a heart-failure and transplant cardiologist at Penn, said diabetics with severe heart failure who are doing well on liraglutide should not quit the drug - but he wouldn't put them on it.

www.philly.com/philly/health/diabetes/20160803_Popular_diabetes_drug_Victoza_does_not_help_severe_heart_failure.html

Victoza is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (1).
Important Limitations of Use (1.1):

12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
Liraglutide is an acylated human Glucagon-Like Peptide-1 (GLP-1) receptor agonist with 97% amino acid sequence homology to endogenous human GLP-1(7-37). GLP-1(7-37) represents <20% of total circulating endogenous GLP-1. Like GLP-1(7-37), liraglutide activates the GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase by the stimulatory G-protein, Gs, in pancreatic beta cells. Liraglutide increases intracellular cyclic AMP (cAMP) leading to insulin release in the presence of elevated glucose concentrations. This insulin secretion subsides as blood glucose concentrations decrease and approach euglycemia. Liraglutide also decreases glucagon secretion in a glucose-dependent manner. The mechanism of blood glucose lowering also involves a delay in gastric emptying.
•
Not recommended as first-line therapy for patients inadequately controlled

www.accessdata.fda.gov/drugsatfda_docs/label/2010/022341lbl.pdf

Note people on afrezza are not reporting, nausea or diarrhea.