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Post by findingomega on Sept 24, 2016 8:52:28 GMT -5
About 18 months to 2 years ago I contacted Mannkind about a potential combination of a drug with Technosphere. I won't include any names, let's say that top execs at Mannkind do sometimes return emails. I did not hear back until I wrote again last month. It was an honest and obvious answer, financial constraints, however, it did not address whether my idea will be considered OR whether it is even a viable candidate to be combined with Technosphere. I find it odd that Mannkind asked that I keep the idea to myself which I promised both times to do. I no longer will remain quiet because I feel that my idea has potential and I have endured more than enough pain without a hint of relief when gauged by equity price. My hope is that there are competent people here who have a sound knowledge of how TS works and the types of drugs that can be combined with it. The combination I would like to see is Technosphere and anti-anxiety drugs.
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Post by peppy on Sept 24, 2016 8:56:53 GMT -5
About 18 months to 2 years ago I contacted Mannkind about a potential combination of a drug with Technosphere. I won't include any names, let's say that top execs at Mannkind do sometimes return emails. I did not hear back until I wrote again last month. It was an honest and obvious answer, financial constraints, however, it did not address whether my idea will be considered OR whether it is even a viable candidate to be combined with Technosphere. I find it odd that Mannkind asked that I keep the idea to myself which I promised both times to do. I no longer will remain quiet because I feel that my idea has potential and I have endured more than enough pain without a hint of relief when gauged by equity price. My hope is that there are competent people here who have a sound knowledge of how TS works and the types of drugs that can be combined with it. The combination I would like to see is Technosphere and anti-anxiety drugs. The drugs being marketed now as anti anxiety are the ssri's
No way will lorazepam be put on technosphere there is no need. Oral antianxieties drugs work.
I do not say this because I want to disagree. Thanks for posting omega.
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Post by nimrod71 on Sept 24, 2016 9:05:26 GMT -5
Hi Omega isn't it a little late for that? Zero sales coming in on our main product, and the company seems to be in dire straights. Once again there is no time left. Honestly look at the whole picture soak everything in-the end is near. Anything short of a miracle is useless.
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Post by mnkdfann on Sept 24, 2016 9:11:53 GMT -5
Hi Omega isn't it a little late for that? Zero sales coming in on our main product, and the company seems to be in dire straights. Once again there is no time left. Honestly look at the whole picture soak everything in-the end is near. Anything short of a miracle is useless. You sound a little, dare I say, anxious about MNKD's prospects. I think findingomega had the foresight to spot a developing market on this board and was hoping to tap it.  |
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Post by nimrod71 on Sept 24, 2016 9:21:35 GMT -5
Too little Too late.
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Post by findingomega on Sept 24, 2016 9:40:08 GMT -5
Hi Omega isn't it a little late for that? Zero sales coming in on our main product, and the company seems to be in dire straights. Once again there is no time left. Honestly look at the whole picture soak everything in-the end is near. Anything short of a miracle is useless. You sound a little, dare I say, anxious about MNKD's prospects. I think findingomega had the foresight to spot a developing market on this board and was hoping to tap it. Should Principal Investigators be principaled. Glad you think you're funny, I don't. Seems you'll take advantage of a post just to get your doom and gloom spread. Please explain (as I asked in my post) if this would be a viable drug combo with TS. If not, head over to YMB for your level of discussion. |
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Post by mnkdfann on Sept 24, 2016 9:44:48 GMT -5
You sound a little, dare I say, anxious about MNKD's prospects. I think findingomega had the foresight to spot a developing market on this board and was hoping to tap it. Should Principal Investigators be principaled. Glad you think you're funny, I don't. Seems you'll take advantage of a post just to get your doom and gloom spread. Please explain (as I asked in my post) if this would be a viable drug combo with TS. If not, head over to YMB for your level of discussion. Lighten up. But since you asked, do I think your idea has merit? Not really. See peppy's reply. |
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Post by peppy on Sept 24, 2016 9:48:49 GMT -5
How fast do they work? Have you ever seen someone with POTS have a massive panic attack? I see your point. I have seen panic attacks. What does medicine give for those now?
Medicine does not seem to allow the good stuff to be given.
Out of patent and all.
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Post by matt on Sept 24, 2016 9:57:26 GMT -5
You didn't say exactly which antianxiety drugs. The trick to any drug delivery system is to get the drug where it needs to go, in the form it needs to be in to deliver a therapeutic effect. What can be absorbed in any given part of the human body, whether the oral cavity, through the skin, the stomach, the upper GI tract, the lower GI tract, or in the lung, depends entirely on the specific molecule(s) or protein(s), its chemical stability, the pharmacokinetics, and its size. Suffice it to say that the question is complex enough that you are not likely to a satisfactory answer on a message board.
However, as peppy noted most of the current drugs on the market have high oral availability which means that pills work just fine for delivering the drug. It would be a hard sell to change the dosage form of an orally available drug unless the current drugs are not working.
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Post by findingomega on Sept 24, 2016 10:08:15 GMT -5
How fast do they work? Have you ever seen someone with POTS have a massive panic attack? I see your point. I have seen panic attacks. What does medicine give for those now?
Medicine does not seem to allow the good stuff to be given.
Out of patent and all.
I am not certain I am using the right format to answer, if not please instruct me where to find directions, I have searched and read but nothing seems to be exactly what I require to understand how to reply specifically. The drugs used are the type you mentioned. The onset of relief is measured in tens of minutes. POTS sufferers are obviously not the only group that would benefit from this. I have a daughter with POTS who through other meds and education has brought it under control, however during her episodes I witnessed terror that one can't conceive of unless they are the victim or a witness. I was stunned to learn how many others (not necessarily POTS sufferers) are being medicated with anti-anxiety meds. Scary, it is an over-prescribed class of medications in my opinion. If these drugs were to be made ulta-fast acting there may be an ability to reduce the size of doses and frequency of use. If I were someone who experienced panic attacks my fear of one would cause me to medicate prior to avoid the terror. If I knew I had relief available within minutes I might be more inclined to escape the side effects of the drug except when inhaling to quell an attack.Of course there would be plenty of room for abuse but that is what is occurring right now with oral meds. |
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Post by mannmade on Sept 24, 2016 10:22:13 GMT -5
It is my understanding that most of these types of drugs take several weeks of absorption before they become effective. How would one dose work? And then people must stay on them or risk side effects for going on and off.
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Post by agusta on Sept 24, 2016 10:28:15 GMT -5
ALEXA Pharma - just closed it's doors a few months back. They sold everything to Grupper (something) in Spain. Had an inhaled drug for anxiety....Did not catch on and was too expensive. Of course I owned that stock and lost my ....
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Post by findingomega on Sept 24, 2016 10:28:39 GMT -5
You didn't say exactly which antianxiety drugs. The trick to any drug delivery system is to get the drug where it needs to go, in the form it needs to be in to deliver a therapeutic effect. What can be absorbed in any given part of the human body, whether the oral cavity, through the skin, the stomach, the upper GI tract, the lower GI tract, or in the lung, depends entirely on the specific molecule(s) or protein(s), its chemical stability, the pharmacokinetics, and its size. Suffice it to say that the question is complex enough that you are not likely to a satisfactory answer on a message board. However, as peppy noted most of the current drugs on the market have high oral availability which means that pills work just fine for delivering the drug. It would be a hard sell to change the dosage form of an orally available drug unless the current drugs are not working. The class of drugs used fall into the lorazepam and similars. It is my understanding that attaching such drugs (if possible) would allow for new patents. Orals work, yes, however, they are not very quick. Please read my response to Peppy. I do understand the complexity of making a perfect match to meet the symptoms. I posted here hoping someone who understood the chemistry might "throw in" their thoughts. The potential for that occurring here is much higher than on other boards. |
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Post by nimrod71 on Sept 24, 2016 10:31:16 GMT -5
Doom and gloom right gotcha. How come every time someone is negative or not as up beat as most unrealistic pumpers they are just passed off as a basher? Ok I guess I'm just a basher stuck with just over 14000 shares of this clunker. I guess my main question is how do you suggest Mnkd after everything you know already can pull off what your saying. Matt hasn't followed through on anything and there is no time or money left. Just one bashers opinion.
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Post by slugworth008 on Sept 24, 2016 10:37:13 GMT -5
Doom and gloom right gotcha. How come every time someone is negative or not as up beat as most unrealistic pumpers they are just passed off as a basher? Ok I guess I'm just a basher stuck with just over 14000 shares of this clunker. I guess my main question is how do you suggest Mnkd after everything you know already can pull off what your saying. Matt hasn't followed through on anything and there is no time or money left. Just one bashers opinion. Well you hold onto those shares little buckaroo - Ya never know what might happen in the saga that IS MNKD. |
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