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Post by prosper on Sept 24, 2016 10:53:09 GMT -5
Most of the talk about the Epi application with Technosphere has been centered around cost. Omega's questions make me want to ask if TechnosphereEpi would theoretically act faster than EpiPen. I think the same question applies to Omega's concept both in the possibility of not having a panic victim not have to take chronic regular meds but only when an attack occurs, and next, having seen panic attacks, could a Technosphere panic drug be much faster and, just like Afrezza, but a booster in exceptional situations.
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Post by findingomega on Sept 24, 2016 11:05:27 GMT -5
Doom and gloom right gotcha. How come every time someone is negative or not as up beat as most unrealistic pumpers they are just passed off as a basher? Ok I guess I'm just a basher stuck with just over 14000 shares of this clunker. I guess my main question is how do you suggest Mnkd after everything you know already can pull off what your saying. Matt hasn't followed through on anything and there is no time or money left. Just one bashers opinion. The doom side is obvious so you should feel comfort in numbers. The upside is very difficult to see (if there is one). I have lost a lot more money than you have and understand the potential collapse that is looming, however, it is a wonder drug and eventually it will prevail whether through MNKD (hopefully) or someone else. I don't understand why you are still long. Sell if what you are saying is heartfelt. I prefer to remain long because conventional wisdom is usually anything but.
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Post by peppy on Sept 24, 2016 11:09:10 GMT -5
I see your point. I have seen panic attacks. What does medicine give for those now?
Medicine does not seem to allow the good stuff to be given.
Out of patent and all.
I am not certain I am using the right format to answer, if not please instruct me where to find directions, I have searched and read but nothing seems to be exactly what I require to understand how to reply specifically. The drugs used are the type you mentioned. The onset of relief is measured in tens of minutes. POTS sufferers are obviously not the only group that would benefit from this. I have a daughter with POTS who through other meds and education has brought it under control, however during her episodes I witnessed terror that one can't conceive of unless they are the victim or a witness. I was stunned to learn how many others (not necessarily POTS sufferers) are being medicated with anti-anxiety meds. Scary, it is an over-prescribed class of medications in my opinion. If these drugs were to be made ulta-fast acting there may be an ability to reduce the size of doses and frequency of use. If I were someone who experienced panic attacks my fear of one would cause me to medicate prior to avoid the terror. If I knew I had relief available within minutes I might be more inclined to escape the side effects of the drug except when inhaling to quell an attack.Of course there would be plenty of room for abuse but that is what is occurring right now with oral meds. Because I am crazy, consider a grounding pad. www.earthing.com/what-is-earthing/ put it just under her pillow? can not hurt.
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Post by nimrod71 on Sept 24, 2016 11:58:41 GMT -5
Nope not selling to stubborn. I'm just gonna hold and pray for a miracle. Honestly technically I'm still long just disgruntled. I personally find It hard stay positive I bought in 6 years ago and have watched this comedy of errors in disbelief ever since.
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Post by audiomr on Sept 24, 2016 12:11:25 GMT -5
Most of the talk about the Epi application with Technosphere has been centered around cost. Omega's questions make me want to ask if TechnosphereEpi would theoretically act faster than EpiPen. I think the same question applies to Omega's concept both in the possibility of not having a panic victim not have to take chronic regular meds but only when an attack occurs, and next, having seen panic attacks, could a Technosphere panic drug be much faster and, just like Afrezza, but a booster in exceptional situations. Epi-pens do not have to be nearly as costly as they currently are. And injected epi takes effect quickly enough that the TS advantage would not matter much. Epi-TS has other advantages, though. A big one is that it would be much smaller and thus much easier to carry around. Another is that you don't have to jab yourself with a big needle. Both make it far more likely that the medication will be used promptly when needed, especially by children. Speed benefit could be significant for anti-anxiety.
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Post by sophie on Sept 24, 2016 17:34:51 GMT -5
You didn't say exactly which antianxiety drugs. The trick to any drug delivery system is to get the drug where it needs to go, in the form it needs to be in to deliver a therapeutic effect. What can be absorbed in any given part of the human body, whether the oral cavity, through the skin, the stomach, the upper GI tract, the lower GI tract, or in the lung, depends entirely on the specific molecule(s) or protein(s), its chemical stability, the pharmacokinetics, and its size. Suffice it to say that the question is complex enough that you are not likely to a satisfactory answer on a message board. However, as peppy noted most of the current drugs on the market have high oral availability which means that pills work just fine for delivering the drug. It would be a hard sell to change the dosage form of an orally available drug unless the current drugs are not working. I'd just like to add just a little bit to what you said. Bioavailability of inhaled medications should be much higher than orally ingested medicine because inhaled medications bypass the liver as well as the GI system. This changes what is needed in developing the formulation of the drug i.e. pH considerations as well as increased concentration of medicine to reach the target tissue- often the upper/lower bowels as that's where most nutrient absorption takes place, etc. If I was MNKD (with all their extra employees, I know.... Oh wait! There's Hakan... he should be doing this) I'd research previous medications (hopefully off patent) that showed great therapeutic benefits but proved to be too toxic to prescribe due to the metabolites of the active ingredients. It seems to me (and this is just application of knowledge I have, I don't know if this would actually work) that if they can find a drug that can be given through inhalation that is safe for the lungs, and proves to be safe due to a lower dosage of active ingredients, that they may be able to piggy back on what's already been done and just reformulate it with TS. I'm not exactly sure if pharmas test all formulations, I'd imagine so- spending all that money to bring it to market would hope to land it at least in a hospital, but if they shelved a drug because they didn't think it had enough retail value, there might be some good drugs out there that just need to be reformulated. Please tell me that MNKD has mentioned something like this in the past? It kind of seems like a no brainer to at the very least have on the radar.
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