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Post by mnholdem on Sept 28, 2016 9:37:57 GMT -5
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Post by dh4mizzou on Sept 28, 2016 14:46:59 GMT -5
That's got everything but a reference to Afrezza. There has got to be a commercial in there somewhere.
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Post by LosingMyBullishness on Oct 5, 2016 7:36:55 GMT -5
IMO designed to run before introducing Afrezza to the audience.
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Post by mnholdem on Oct 5, 2016 8:04:44 GMT -5
The video explains the significance of the 1st pass insulin response of a healthy pancreas and how it functions to signal the liver into shutting down glucose production at mealtime, which emphasizes WHY the speed of Afrezza inhaled insulin is such a big deal.
First Phase Insulin Release
When a healthy person starts to eat a meal, the beta-cells kick into high gear. Their stored insulin is released immediately. Then, if the blood sugar concentration rises over 100 mg/dl, (5.5 mmol/L) the beta-cells start secreting more insulin into the blood stream. This early release of stored insulin after a meal is called "First Phase Insulin Release." In a healthy person it keeps the blood sugar from rising very high because it is available to meet most of the glucose that comes from the digestion of the current meal.
Failing beta-cells
In most patients with early Type 2 diabetes, the first phase insulin release fails because beta-cells are dysfunctional or dying. This can happen along with insulin resistance, or without it. Studies have found that some thin, non-insulin resistant relatives of people with Type 2 Diabetes already show signs of beta cell dysfunction.
If beta-cells are dying or not working properly the remaining beta-cells may be working full-time just to keep up with the need for a basal insulin release so they can't store any excess in those granules for later release.
Some people with type 2 diabetes appear to have a defect which makes their beta-cells die when they attempt to reproduce in response to a need for more insulin. For these people, insulin resistance can cause the beta-cells to try to divide and then die, hastening on the degenerative process.
Glucose Toxicity
Whatever the reason for the failing first phase insulin release there's an ugly feedback mechanism that kicks in when blood sugar levels rise because of that failing first phase insulin release: High levels of circulating glucose themselves are toxic to beta-cells, a phenomenon called "glucose toxicity". So as blood sugars rise these high blood sugar concentrations further damage and or kill more beta-cells, making first and second phase insulin release even less able to control blood sugar concentrations.
Increased Insulin Resistance
If your beta-cells are still able to secrete enough insulin to provide a second phase insulin release, your body may be able to bring the blood sugar back down to a normal level by 3 hours and may then go back to secreting the small amounts of basal insulin which maintain a normal or near-normal blood sugar level while you are between meals or asleep. But when first phase insulin release is weak or missing your blood sugar may easily rise over the 200 mg/dl (11 mmol/L) level currently defined as "diabetes."
At that point, two bad things happen. When the concentration of glucose in your blood reaches 200 mg/dl (11 mmol/L) your cells become insulin resistant even if they weren't insulin resistant before, so it takes a lot more insulin to lower your blood sugar from that point on.
And, even worse, the lack of a robust insulin response to the rising glucose may erroneously be interpreted by your liver as a sign that blood sugar is too low and that it is time to dump more glucose into the bloodstream. So in addition to the glucose coming in from your recent meal you also have to contend with additional glucose dumped by your poor old confused liver.
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NOTE: Sam Finta has stated and Dr. Bode (Sam's endo) has confirmed that his insulin resistance began improving after he began treatment with Afrezza insulin. That should not be a surprise, but it would be for many physicians because the ADA and similar organizations have not done a sufficient job of educating the medical community on the importance of simulating a healthy pancreas. If they had, then insulin would not be the last step in diabetes treatment. Insulin therapy should be the first step in the treatment of patients diagnosed with early-stage Type 2 diabetes mellitus.
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