Anyone have access to Matt to ask him a question?

[notamnkdmillionaire]

I am curious to know if Technosphere could be used for the inhalation of clotting factors and IVIG. I realize that hemophilia has  a relatively small patient base but it is an important one. IVIG is ~ 3.6 Billion dollar business.

While no where as big as Diabetes, it's still an interesting market that Technosphere could play a big roll in.

I know there are only a small handful of companies that are in this sector so competition is fierce. I also know that Grifols (GRFS) has partnered with Aradigm (ARDM- who coincidentally was also trying to manufacture inhalable insulin but dropped it) for inhalable Cipro.

Baxter is the biggest company in the sector and just think if they wanted that competitive edge to get their products out of the needle and into the dreamboat. I am sure Hemophiliac would love it!

[jpg]

Interesting question.

For IVIG I can safely say no. The dosage needs to be in grams and not mg as can be inhaled.

For hemophilia I don't know but the dosages are at least much smaller.

[chmith27]

agree jpg. doubt we have much benefit with hemophilia since ddavp is already nasal-unless the amount delivered by technosphere could be markedly lower? any hematologists lurkin around? good post approval question in general and maybe then mnkd could let us in on what they've got up their sleeve.

[alcc]

Curious, why hasn't the sublingual path been more fully exploited? What are SL's limitations?

[jpg]

I think he is referring to factors VIII (recombinant and plasma derived) and IX (recombinant) more then DDAVP? They are a pain to give IV and hemophiliacs would benefit greatly from self administering them by inhalation. They are very big and heavy though so not certain Technosphere could handle this?

IMO what Biogen is doing with Alprolix (approved last week...) is the way these types of deficiencies will be managed:

finance.yahoo.com/news/fda-approves-biogen-idec-alprolix-222400978.html

Clever stuff!

JPG

[thekindaguyiyam]

Apr 4, 2014 11:39:22 GMT -5 chmith27 said:

agree jpg. doubt we have much benefit with hemophilia since ddavp is already nasal-unless the amount delivered by technosphere could be markedly lower? any hematologists lurkin around? good post approval question in general and maybe then mnkd could let us in on what they've got up their sleeve.

I thought I heard something in a CC where Al said something about a surprise.  Or am I dreaming this.
Can you or anyone here confirm a short statement like that?  Good Morning!