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Post by peppy on Dec 2, 2016 10:42:13 GMT -5
Quote from last post on last page; kball says: Must have made holidays and family get togethers fun for everyone Reply
let's see Kball. If the price of MNKD double between now and the holidays, I will feel better. Pep
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Post by radgray68 on Dec 2, 2016 11:22:20 GMT -5
Following true Mannkind luck, and just in time to pour sand in our lane, the newly appointed Attorney General, Sessions, has been brainwashed or bought out against marijuana. I suggest these officials who oppose legalization have been bribed only because I know the enormous sums of money on the line for all the crooked DEA agents and cartels. Though completely frickin harmless, marijuana is STILL listed with the worst substances on earth. The only piece of the puzzle that fits is corruption, to my mind. They would lose billions in graft that they've been used to collecting during the absolute failure of the 30 year "war on drugs."
I am hopeful that Trump will be pragmatic on this issue and he directs the AG to go after the drugs that ruin lives. Jobs and GDP are higher on his agenda, supposedly. There is a USA Today article on the topic, but I'm such a Luddite I don't know how to attach it to this post. Man, I miss Windows 95. I also miss my Commodore 64 and Atari 2600, but that's neither here nor there. Suffice it to say, the marijuana issue isn't settled yet even though the people have spoken in favor of it.
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Post by peppy on Dec 2, 2016 11:29:57 GMT -5
consider if teva's medication a success, Pharma will not want to miss out. Monkey see, Monkey do. Technosphere an excellent delivery system. Dosed. Pharmaceutical grade.
You do make the point, trump a corporate tool? I created 100,000 jobs by decriminalizing marijuana. Let something good come out of this.
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Post by lennymnkd on Dec 2, 2016 11:34:55 GMT -5
Can the technospere platform be applied to TEVA's electronic device ...
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Post by novafett on Dec 2, 2016 11:49:15 GMT -5
Up 9c and 20% on 3.6M shares and only half way into the day. Someone must know something!! haha
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Post by madog365 on Dec 2, 2016 12:02:46 GMT -5
My guess is pain management is the first area they are working on and largest market potential. time.com/4419003/can-medical-marijuana-help-end-the-opioid-epidemic/A couple years back Mannkind listed pain relief as a top contender for Technosphere and i remember interviews with Al Mann where he specifically said it would be the next area Mannkind would pursue after diabetes. Fast forward a few years Pain Management is no longer in the pipeline and epi is next up. Not to mention, most of Andrea Leone's patents and presentations are in this area as well.
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Post by bioexec25 on Dec 2, 2016 12:25:38 GMT -5
I wonder what drove the shift in strategy Madog (Mattis). :-)
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Post by mango on Dec 2, 2016 18:23:26 GMT -5
This delusional person wonders why so many people still speculate about RLS considering they handed the public their top notch business plan and exposed their "pedigree" of a management team. Drops, Tabs, and Pods folks. Move along, you're delusional if you believe this is not up to par science and technology. And do not dare question the mind blowing pedigree of a management team. Or the quality of a pdf. Rememeber that this leaked on Stocktwits, folks, the most reliable source of information on the web.
🙄
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Post by lennymnkd on Dec 2, 2016 18:45:10 GMT -5
Peppy / can the technosphere platform be used on teva's electronic device .. Adjusted dosage / sounds like it could have some benefit to us as well ..
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Post by peppy on Dec 2, 2016 18:53:17 GMT -5
Peppy / can the technosphere platform be used on teva's electronic device .. Adjusted dosage / sounds like it could have some benefit to us as well .. I do not think so. Teva device looks like absorption may be through the mucus membranes. Technosphere, absorption through alveoli in the lungs.
More swallowing of a nasal spray I would think than technosphere.
An interesting aside, eating, versus lung delivery. "eaten cannabis gets metabolized by the liver, so delta-9 THC becomes 11-hydroxy-THC, which passes the blood-brain barrier more rapidly and has more of a psychedelic effect than standard THC,” says Understanding Marijuana author Mitch Earleywine, a professor of psychology at the State University of New York at Albany. “Smoked or vaporized cannabis bypasses the liver and doesn’t create the same 11-hydroxy-THC.”
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Post by mango on Dec 2, 2016 18:53:39 GMT -5
Peppy / can the technosphere platform be used on teva's electronic device .. Adjusted dosage / sounds like it could have some benefit to us as well .. Technosphere is a vehicle for virtually all drug delivery. And the cannabis "inhalers" are not TEVA's devices or tech, it is Syqe Medical's. And why on earth would you ever want a damn tobacco company to be within an arm's reach of Technosphere. TEVA is in it for the same reasons Big Tobacco gets away with being on the stock exchange while providing a pack of cancer. MannKind is the company everyone hates because MannKind actually helps people. Phillip Morris and TEVA can have a ball with Syqe's crap "inhalers". Have you checked out the patent on them? Oh yeah, wait, nvm...
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Post by lennymnkd on Dec 2, 2016 19:09:07 GMT -5
Thanks a bunch ! Appreciate it .
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Post by sophie on Dec 2, 2016 19:10:33 GMT -5
“Smoked or vaporized cannabis bypasses the liver and doesn’t create the same 11-hydroxy-THC.” Can't say for sure since I'm not sure how stable it is, but this doesn't have to be a problem with technosphere. Assuming they can isolate 11-hydroxy-THC (or an analog) in vitro and stably bind it to FDKP, it would still be able to be administered through the lungs.
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Post by lennymnkd on Dec 2, 2016 19:13:45 GMT -5
Peppy / can the technosphere platform be used on teva's electronic device .. Adjusted dosage / sounds like it could have some benefit to us as well .. I do not think so. Teva device looks like absorption may be through the mucus membranes. Technosphere, absorption through alveoli in the lungs.
More swallowing of a nasal spray I would think than technosphere.
An interesting aside, eating, versus lung delivery. "eaten cannabis gets metabolized by the liver, so delta-9 THC becomes 11-hydroxy-THC, which passes the blood-brain barrier more rapidly and has more of a psychedelic effect than standard THC,” says Understanding Marijuana author Mitch Earleywine, a professor of psychology at the State University of New York at Albany. “Smoked or vaporized cannabis bypasses the liver and doesn’t create the same 11-hydroxy-THC.”
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Post by lennymnkd on Dec 2, 2016 19:22:42 GMT -5
Thanks peppy / was thinking for future applications .. The adjusted dosage and automatic titration had me going !
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