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Post by seanismorris on Dec 2, 2016 20:23:57 GMT -5
Is it just me or is everyone getting excited about nothing?
There are a lot of inhalers out there, until there is an an actual announcement from MannKind it's all fud. Might as well discuss Technosphere + MAGIC mushrooms; that was also in the news.
I would like to see MannKind develop a metered inhaler. Maybe that would spike more interest in TS... The breath powered inhaler is great, be isn't buz worthy. (Apparently)
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Post by dreamboatcruise on Dec 2, 2016 22:01:44 GMT -5
Is it just me or is everyone getting excited about nothing? There are a lot of inhalers out there, until there is an an actual announcement from MannKind it's all fud. Might as well discuss Technosphere + MAGIC mushrooms; that was also in the news. I would like to see MannKind develop a metered inhaler. Maybe that would spike more interest in TS... The breath powered inhaler is great, be isn't buz worthy. (Apparently) Would be interesting if they've worked on metered.
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Post by goyocafe on Dec 3, 2016 1:44:21 GMT -5
Is it just me or is everyone getting excited about nothing? There are a lot of inhalers out there, until there is an an actual announcement from MannKind it's all fud. Might as well discuss Technosphere + MAGIC mushrooms; that was also in the news. I would like to see MannKind develop a metered inhaler. Maybe that would spike more interest in TS... The breath powered inhaler is great, be isn't buz worthy. (Apparently) Would be interesting if they've worked on metered. Better yet, Bluetooth enabled to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems like Onduo, giving patient specific and algorithmic derived feedback to the PWD and his/her caregiver. The metering will be driven by dose specific "pods" (per the memo).
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Post by brotherm1 on Dec 3, 2016 2:42:00 GMT -5
"APPARATUS AND METHOD FOR SIMULATING INHALATION EFFORTS
An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided."
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Post by peppy on Dec 3, 2016 6:24:54 GMT -5
Would be interesting if they've worked on metered. Better yet, Bluetooth enabled to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems like Onduo, giving patient specific and algorithmic derived feedback to the PWD and his/her caregiver. The metering will be driven by dose specific "pods" (per the memo). quote: to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems
reply: I know Mannkind has enabled inhaler, I do not want to go through the effort of the search for a link. My comment for all medications: "communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems" I do not want this in "my" life. Just sayin.
I believe what MNKD has enabled is an inhaler that allows for a Spirometry of sorts.
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Post by audiomr on Dec 3, 2016 12:19:31 GMT -5
Following true Mannkind luck, and just in time to pour sand in our lane, the newly appointed Attorney General, Sessions, has been brainwashed or bought out against marijuana. I suggest these officials who oppose legalization have been bribed only because I know the enormous sums of money on the line for all the crooked DEA agents and cartels. Though completely frickin harmless, marijuana is STILL listed with the worst substances on earth. The only piece of the puzzle that fits is corruption, to my mind. They would lose billions in graft that they've been used to collecting during the absolute failure of the 30 year "war on drugs." I am hopeful that Trump will be pragmatic on this issue and he directs the AG to go after the drugs that ruin lives. Jobs and GDP are higher on his agenda, supposedly. There is a USA Today article on the topic, but I'm such a Luddite I don't know how to attach it to this post. Man, I miss Windows 95. I also miss my Commodore 64 and Atari 2600, but that's neither here nor there. Suffice it to say, the marijuana issue isn't settled yet even though the people have spoken in favor of it. There are still plenty of old men -- Sessions, for example -- who genuinely believe that marijuana is itself a dangerous drug not to mention a gateway to even worse. You'd think the battles of the '60s would have subsided by now, but I guess my generation is a tenacious lot.
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Post by audiomr on Dec 3, 2016 12:21:36 GMT -5
I wonder what drove the shift in strategy Madog (Mattis). :-) Driven by need for speed and limited resources. This is why EpiHale is not at the front of the queue.
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Post by audiomr on Dec 3, 2016 12:27:35 GMT -5
Better yet, Bluetooth enabled to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems like Onduo, giving patient specific and algorithmic derived feedback to the PWD and his/her caregiver. The metering will be driven by dose specific "pods" (per the memo). quote: to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems
reply: I know Mannkind has enabled inhaler, I do not want to go through the effort of the search for a link. My comment for all medications: "communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems" I do not want this in "my" life. Just sayin.
I believe what MNKD has enabled is an inhaler that allows for a Spirometry of sorts.
It's called BluHale. You can read about it here: www.mannkindcorp.com/research-development/tech-platforms/inhalation-profiling. It's a patient-training and inhaler R&D tool.
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Post by lennymnkd on Dec 3, 2016 12:57:08 GMT -5
Thanks for the link!
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Post by matt on Dec 4, 2016 6:39:20 GMT -5
There are still plenty of old men -- Sessions, for example -- who genuinely believe that marijuana is itself a dangerous drug not to mention a gateway to even worse. You'd think the battles of the '60s would have subsided by now, but I guess my generation is a tenacious lot. Mr. Sessions is right, at least in part. Cannabis used improperly can be a dangerous drug, but you can say the same about many, many prescription drugs; that is why they are not available to the general public without a prescription. Cannabis is, and remains, a Schedule I drug which means that 99% of physicians writing scripts for "medical marijuana" are breaking federal law and could find themselves without a license to prescribe drugs (most drug licenses are for Schedules II and higher, but not Schedule I). Given the sheer explosion of the medical marijuana business where state law had made it legal either a whole lot of people in California and Colorado have cancers or other serious illnesses, or else there are a lot of recreational users with a friendly physician. It is not that FDA is against the active agents in cannabis, it is that they haven't been formulated and proven to be consistently effective. Some company will take the next step and do the testing, and that company will get an approved NDA indicated for all sorts of diseases. Either we operate with a properly regulated pharmaceuticals market, or we need to go back to the days before the FDA was created and let anybody sell what they want (that didn't work so well). You can't have it both ways.
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Post by peppy on Dec 4, 2016 7:17:39 GMT -5
Quote from above: It is not that FDA is against the active agents in cannabis, it is that they haven't been formulated and proven to be consistently effective. Some company will take the next step and do the testing, and that company will get an approved NDA indicated for all sorts of diseases. Either we operate with a properly regulated pharmaceuticals market, or we need to go back to the days before the FDA was created and let anybody sell what they want (that didn't work so well). You can't have it both ways.
Reply: Catch 22. The quoted individual is saying all the correct words. Too bad the individual does not know the laws the way they are written prevent this. "NIDA has a congressional mandate to study substances of abuse AS SUBSTANCES OF ABUSE. We are the national institute ON DRUG ABUSE NOT for Drug abuse. So we can not give you marijuana to see if it has a medicinal benefit."
23 minutes into the video.
www.youtube.com/watch?v=2ukz7YfStkI
Quote: Cannabis is, and remains, a Schedule I drug which means that 99% of physicians writing scripts for "medical marijuana" are breaking federal law and could find themselves without a license to prescribe drugs (most drug licenses are for Schedules II and higher, but not Schedule I).
Reply: The quoted individual does not know physicians are licensed by state law? healthaffairs.org/blog/2014/02/18/doctors-without-state-borders-practicing-across-state-lines/ The quoted individual does not know morphine sulfate and heroin are the same thing? As Attorney general, Sessions knows the real story on state and UNITED STATES jurisdiction? I think if there was something the UNITED STATES could do about the states rights in this matter it would have been done. Look at when this movement of states rights all came about. It came about after information could be disseminated and individuals figured out states could do this with out the UNITED STATES being able to stop the states rights. Chances are the UNITED STATES OF AMERICA population have been dumbed down about what national and state laws really say.
Drugs / Substances listed in DEA Schedule I include: •Heroin (diacetylmorphine) •LSD (Lysergic acid diethylamide) •Marijuana (cannabis, THC) •Mescaline (Peyote) •MDMA (3,4-methylenedioxymethamphetamine or “ecstasy”) •GHB (gamma-hydroxybutyric acid) •Ecstasy (MDMA or 3,4-Methylenedioxymethamphetamine) •Psilocybin •Methaqualone (Quaalude) •Khat (Cathinone) •Bath Salts (3,4-methylenedioxypyrovalerone or MDPV)
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Post by brotherm1 on Dec 4, 2016 11:53:48 GMT -5
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Post by dreamboatcruise on Dec 5, 2016 11:45:17 GMT -5
Would be interesting if they've worked on metered. Better yet, Bluetooth enabled to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems like Onduo, giving patient specific and algorithmic derived feedback to the PWD and his/her caregiver. The metering will be driven by dose specific "pods" (per the memo). There are pill bottles made to record compliance and yet those certainly haven't taken off. It would be pretty simple to build such technology into an insulin pen, but that hasn't happened. I suspect that info on blood glucose would be viewed as much more important than a record of insulin dosing. Metering probably isn't necessary for insulin, but there may be some APIs that would not be as tolerant to coarse dosing levels.
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Post by peppy on Dec 5, 2016 13:02:52 GMT -5
Better yet, Bluetooth enabled to communicate dosing and compliance information to an IOT device and on to the cloud for monitoring by big data systems like Onduo, giving patient specific and algorithmic derived feedback to the PWD and his/her caregiver. The metering will be driven by dose specific "pods" (per the memo). There are pill bottles made to record compliance and yet those certainly haven't taken off. It would be pretty simple to build such technology into an insulin pen, but that hasn't happened. I suspect that info on blood glucose would be viewed as much more important than a record of insulin dosing. Metering probably isn't necessary for insulin, but there may be some APIs that would not be as tolerant to coarse dosing levels. Interesting. I am not sure who any one has to comply with. I guess knowing this, if I got a medication filled that I did not want to take, I could take it out of the bottle, and place the medication in a bowl. An insulin pen that measures compliance? heh. Air Insulin? (I am so cheap, I would probably suck it into a syringe.)
What the heck is this compliance stuff? We get to decide our lives. (unless the compliance stuff is measures compiling with afrezza rather than subq, I bet the compliance is better.) image checking my blood glucose after subq insulin and eating just to see the no control numbers. Image the fun of seeing control of blood glucose levels after eating. Priceless?
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Post by nylefty on Dec 5, 2016 14:52:02 GMT -5
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