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Post by Deleted on Feb 2, 2017 7:55:10 GMT -5
Explaining to T2 coworkers of the benefits of Afrezza versus metformin is relatively easy, however, because our insurance currently does not cover Afrezza it is difficult for them to make the switch.
Are there papers that spell out compelling reasons to switch?
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Post by agedhippie on Feb 2, 2017 8:29:46 GMT -5
The only ones I can think of are the early treatment papers. I don't have any links to them but a search in the forums will find them.
If the people are well controlled on metformin then it would be unwise to swap to Afrezza. The benefits would be marginal at best, and the risk, cost, and inconvenience would be a lot higher. There is a risk of over-treating.
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Post by Deleted on Feb 2, 2017 8:47:18 GMT -5
agedhippie that is bull! I have emailed MannKind informing them of my experience and requesting some documentation that will make the case to change. If/when MannKind responds I will post.
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Post by mnkdnewb on Feb 2, 2017 9:01:36 GMT -5
agedhippie that is bull! I have emailed MannKind informing them of my experience and requesting some documentation that will make the case to change. If/when MannKind responds I will post. Why is that bull? People are not going to switch if it costs more money. Until the insurance issue is fixed this is going nowhere.
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Post by Deleted on Feb 2, 2017 9:08:12 GMT -5
mnkdnewb "The benefits would be marginal at best," That is what is bull. Castagna needs to address this or it will be difficult at best to convince T2s to change.
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Post by mnkdnewb on Feb 2, 2017 9:13:03 GMT -5
mnkdnewb "The benefits would be marginal at best," That is what is bull. Castagna needs to address this or it will be difficult at best to convince T2s to change. You seemed to have missed the part where he says "if people are well controlled on metformin". If that is the case then the benefits would indeed be marginal at best.
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Post by peppy on Feb 2, 2017 9:13:45 GMT -5
Explaining to T2 coworkers of the benefits of Afrezza versus metformin is relatively easy, however, because our insurance currently does not cover Afrezza it is difficult for them to make the switch. Are there papers that spell out compelling reasons to switch? I do not see any way a person goes from Metformin alone to Afrezza instead.
Step Therapy.
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Post by Deleted on Feb 2, 2017 9:24:20 GMT -5
peppy that is why Castagna needs to address this dilemma.
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Post by Deleted on Feb 2, 2017 9:35:41 GMT -5
mnkdnewb I did not miss it. Statistically 'well controlled' on paper is very different from 'well controlled' physiologically. That is the only way MannKind will convince the medical community.
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Post by Deleted on Feb 2, 2017 10:04:41 GMT -5
peppy that is why Castagna needs to address this dilemma. give me a billion and I will do trials to reverse the ADA recommendation for care. Until then its moot and waste of discussion. Everyone knows the benefits. But only clinical trials and results will make the payors to pony up $$$ , unless some one wants to pay by them selves or be proactive and get around insurance hurdles.
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Post by lakon on Feb 2, 2017 10:14:48 GMT -5
mnkdnewb I did not miss it. Statistically 'well controlled' on paper is very different from 'well controlled' physiologically. That is the only way MannKind will convince the medical community. Well put! That's the best way I've seen it put in a few words. MNKD needs a trial with CGM's on all patients at all times to collect data on patients on Metformin, Metformin+Afrezza, Tresiba, Tresiba+Afrezza, and Tresiba+RAA. Throw in other basal options to round it out. Show time in range statistics in a graph. Propose long-term studies for the effects. If the doctors could see the huge swings, I think that some might wake up. It seems intuitively better to maintain range. "Statistically 'well controlled' on paper is very different from 'well controlled' physiologically." -- TIME IN RANGE! I've watched T2's just pop a pill and think they are good because the doctor looks at the averages while I watch them guzzle pop and get stuffed. I mention Afrezza. They say that they hope to never need insulin, but would rather inhale if it came down to it.
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Post by mnkdnewb on Feb 2, 2017 10:15:55 GMT -5
mnkdnewb I did not miss it. Statistically 'well controlled' on paper is very different from 'well controlled' physiologically. That is the only way MannKind will convince the medical community. Statistically well controlled on paper is enough to keep almost every diabetic from spending their own money in something that is hypothetically better. a Dr can only say it isn't worse than regular insulin thanks to the label
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Post by mnkdnewb on Feb 2, 2017 10:18:17 GMT -5
mnkdnewb I did not miss it. Statistically 'well controlled' on paper is very different from 'well controlled' physiologically. That is the only way MannKind will convince the medical community. Well put! That's the best way I've seen it put in a few words. MNKD needs a trial with CGM's on all patients at all times to collect data on patients on Metformin, Metformin+Afrezza, Tresiba, Tresiba+Afrezza, and Tresiba+RAA. Throw in other basal options to round it out. Show time in range statistics in a graph. Propose long-term studies for the effects. If the doctors could see the huge swings, I think that some might wake up. It seems intuitively better to maintain range. "Statistically 'well controlled' on paper is very different from 'well controlled' physiologically." -- TIME IN RANGE! I've watched T2's just pop a pill and think they are good because the doctor looks at the averages while I watch them guzzle pop and get stuffed. I mention Afrezza. They say that they hope to never need insulin, but would rather inhale if it came down to it. Man that would be neat! Just need a few hundred million $$$ and about 9 months and we're all set!
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Post by Deleted on Feb 2, 2017 10:18:57 GMT -5
A paper describing the damage that occurs in T2s while taking other drugs is needed. I would be surprised if no such document exists
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Post by mnkdnewb on Feb 2, 2017 10:26:20 GMT -5
A paper describing the damage that occurs in T2s while taking other drugs is needed. I would be surprised if no such document exists It is out there, it's listed in the side effects section for each drug
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