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Post by seanismorris on Apr 13, 2014 3:32:48 GMT -5
I'm reading through a Mannkind patent and I would appreciate some help translating it. It's dated Feb 18, 2014 patentimages.storage.googleapis.com/pdfs/US8653085.pdfIt's seems to be saying Mannkind has protected Technosphere by patenting alternate ways of doing the same thing. But, then it goes into alternative delivery methods inhaled (lung or nose) injected, ingested, or through a patch. Rectal and vaginal delivery is also mentioned. It looks like Mannkind is morphing Technosphere into something that can be used to treat (apply to) any medical need. I'm not sure what is actually covered by Mannkinds patent... For Example: On page 14, radioactive isotopes are mentioned. So, Technosphere could be used (applied) directly to cancers/tumors? It also says more biologically active agents (I.e. insulin) can be carried than previous was achievable. What does this mean for Afrezza? And, more stable (longer shelf life, able to hold up a greater temperature?) And, more than one drug can be attached to a (Technosphere?) particle... So we might a combination drug delivered through Technosphere? Afrezza 2.0 in the works? Or, maybe something to treat pain through multiple receptors? It it also talks about delivering metered douses which is very unlike Afrezza (ultra fast acting) and it seems like it would cover a wide range of products; though very suitable for both acute and chronic pain. What are we really talking about in this patent? Technosphere 2.0?
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Post by liane on Apr 13, 2014 5:45:19 GMT -5
I'm not an expert at reading patents, but this looks fairly standard as embodying every conceivable way the idea can be used. So they have covered a variety chemical modifications on the diketopiperazine ring structure, drugs that can be adsorbed onto the carrier particles, and routes of delivery. I see Technosphere and its analogues being licensed for a variety of drug applications - primarily biologics and protein based entities that currently must be administered via IV so as to not be destroyed in the gut. Each potential drug application will still have to undergo clinical trials to ensure safety and efficacy via the new route. So this is a very long term play. But it is also win-win for both Mannkind and owners of existing drug patents - as it can extend the patent life.
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