U.S. News & World Report—Afrezza

[mango]

New article out today by U.S. News & World Report. I am once again pissed about the obvious.

Insulin 101: How It Works and How to Use It

“The standard practice is to have patients with diabetes on once-a-day basal insulin, which can be the long-acting or ultra long-acting. Rapid-acting is usually added three times a day for mealtime,” Akhter says. The amount of rapid-acting insulin used may depend on your blood sugar and the number of carbs you eat during a meal.

However, insulin use for each diabetes patient will differ. For instance, if you have high blood sugar even after fasting, long-acting insulin would be beneficial. If your fasting blood sugar is normal but the blood sugar gets elevated after meals, then rapid-acting insulin would be more appropriate, Kagan says.

“We try to find out about a person’s life and what they eat to match their insulin to that,” Sisson says.

Unlike other medications, which often come in a pill form, insulin is usually taken as an injection. “It can’t be taken as a pill because it would be broken down during digestion, just like protein in food,” Kagan says. “It must be injected so that it works properly, just like the insulin produced in our bodies.” However, the U.S. Food and Drug Administration recently approved an inhaled insulin, Afrezza. In people with Type 1 diabetes, this new form of insulin still must be used with long-acting insulin. Also, inhaled insulin can’t be used by someone with asthma or chronic obstructive pulmonary disorder,or COPD, Sisson says.

Because many people still use injections to take insulin, it can trigger the fear of needles or self-injections. Yet today’s injection devices are small enough to carry around like an ink pen, and the needles used are tiny. "Sometimes patients are hesitant but once they try it, they say, ‘Is that all it is?’” Sisson says.

Another possible side effect is something called lipohypertrophy, or extra lumps of fat under the skin around a commonly used injection site. That can occur if you don’t rotate your injection site. “It may be unsightly, mildly painful and may change the timing and completeness of insulin action,” Kagan says.

It’s also possible to develop an infection at the injection site. Make sure to wash your hands with soap and water before you do an insulin injection.

Source:
health.usnews.com/health-care/patient-advice/articles/2017-06-13/how-does-insulin-work


• Take away:

—The people that contributed to this article are either not educating themselves or are paid shills. There is just no other explanation for this.

—Mr. Sisson is lying through his teeth when he says insulin pens are harmless and cause no pain. 

—There is zero mention of the positives with using Afrezza, only the fact that it cannot be used in asthmatics and COPDers and the fact it must be used in conjunction with along acting insulin is mentioned. 

—Serious negative side-effects from using insulin injections (which include "pens") are mentioned and brushed aside as if it is less worrisome than using the new inhaled insulin that would actually eliminate many of these potential side effects. 

—Paid shills. 

• If anyone else wants to contact the Pharmacist that commented on Afrezza and properly educate him then his phone number and email are in the link below:

Evan M. Sisson, Pharm.D., MSHA, BCACP, CDE, FAADE

app.pharmacy.vcu.edu/faculty/facdetail.aspx?id=74

[n8]

FAKE NEWS

[centralcoastinvestor]

Did they actually mention Afrezza in the article?  If so, I'm stoked!  That would be one of the first times it would have been mentioned in a major nation wide publication news story.  Could you provide a link?

[sayhey24]

Jun 13, 2017 16:31:08 GMT -5 centralcoastinvestor said:

Did they actually mention Afrezza in the article?  If so, I'm stoked!  That would be one of the first times it would have been mentioned in a major nation wide publication news story.  Could you provide a link?

I think Mango provided both -

Source:
health.usnews.com/health-care/patient-advice/articles/2017-06-13/how-does-insulin-work

"However, the U.S. Food and Drug Administration recently approved an inhaled insulin, Afrezza"

[agedhippie]

Jun 13, 2017 15:33:13 GMT -5 mango said:

health.usnews.com/health-care/patient-advice/articles/2017-06-13/how-does-insulin-work


• Take away:

—The people that contributed to this article are either not educating themselves or are paid shills. There is just no other explanation for this.

—Mr. Sisson is lying through his teeth when he says insulin pens are harmless and cause no pain. 

—There is zero mention of the positives with using Afrezza, only the fact that it cannot be used in asthmatics and COPDers and the fact it must be used in conjunction with along acting insulin is mentioned. 

—Serious negative side-effects from using insulin injections (which include "pens") are mentioned and brushed aside as if it is less worrisome than using the new inhaled insulin that would actually eliminate many of these potential side effects. 

—Paid shills. 

• If anyone else wants to contact the Pharmacist that commented on Afrezza and properly educate him then his phone number and email are in the link below:

Evan M. Sisson, Pharm.D., MSHA, BCACP, CDE, FAADE

app.pharmacy.vcu.edu/faculty/facdetail.aspx?id=74

That's your opinion and you are entitle to it but it doesn't make it correct. I have injected for decades and don't have lipohypertrophy. Nor do modern pen needles hurt in the my opinion and that of the other diabetics I know. There are thicker acupuncture needles!

I do agree that some of his points are silly - washing your hands before you inject? Why exactly since you don't touch the injection site or the needle? Personally I inject straight through my clothes and there was even a study to see if that was bad and it's only finding was that if the cloth was thick it may slightly blunt the needle but there was no infection risk.

As usual the picture is a joke. There is a bubble in the syringe so you don't know how much you are taking. Why exactly are they using a syringe anyway? OMG he is using a 1/2" needle. If he injected like that he would hit muscle as it's a long needle, he should pinch up and go in at an angle. Better yet he should just use a 4mm needle then he could inject like that.

Someone desperately needs to put a decent picture of a modern pen needle into the public domain. Something more like this 4mm needle (1/3rd the length of the one in the article):

[centralcoastinvestor]

Jun 13, 2017 16:40:10 GMT -5 sayhey24 said:

Jun 13, 2017 16:31:08 GMT -5 centralcoastinvestor said:

Did they actually mention Afrezza in the article?  If so, I'm stoked!  That would be one of the first times it would have been mentioned in a major nation wide publication news story.  Could you provide a link?

I think Mango provided both -

Source:
health.usnews.com/health-care/patient-advice/articles/2017-06-13/how-does-insulin-work

"However, the U.S. Food and Drug Administration recently approved an inhaled insulin, Afrezza"

You are correct.  Must of scanned right over the link.  Apologies to Mango.  After reading article, not as excited as my previous post would suggest.  I don't know how many people will actually see this.

[ilovekauai]

Baby steps are good. This is national and will grow. Momentum is everything. One step at a time. We will get there. Aloha.

[mango]

Jun 13, 2017 16:43:03 GMT -5 agedhippie said:

Jun 13, 2017 15:33:13 GMT -5 mango said:

health.usnews.com/health-care/patient-advice/articles/2017-06-13/how-does-insulin-work


• Take away:

—The people that contributed to this article are either not educating themselves or are paid shills. There is just no other explanation for this.

—Mr. Sisson is lying through his teeth when he says insulin pens are harmless and cause no pain. 

—There is zero mention of the positives with using Afrezza, only the fact that it cannot be used in asthmatics and COPDers and the fact it must be used in conjunction with along acting insulin is mentioned. 

—Serious negative side-effects from using insulin injections (which include "pens") are mentioned and brushed aside as if it is less worrisome than using the new inhaled insulin that would actually eliminate many of these potential side effects. 

—Paid shills. 

• If anyone else wants to contact the Pharmacist that commented on Afrezza and properly educate him then his phone number and email are in the link below:

Evan M. Sisson, Pharm.D., MSHA, BCACP, CDE, FAADE

app.pharmacy.vcu.edu/faculty/facdetail.aspx?id=74

That's your opinion and you are entitle to it but it doesn't make it correct. I have injected for decades and don't have lipohypertrophy. Nor do modern pen needles hurt in the my opinion and that of the other diabetics I know. There are thicker acupuncture needles!

I do agree that some of his points are silly - washing your hands before you inject? Why exactly since you don't touch the injection site or the needle? Personally I inject straight through my clothes and there was even a study to see if that was bad and it's only finding was that if the cloth was thick it may slightly blunt the needle but there was no infection risk.

As usual the picture is a joke. There is a bubble in the syringe so you don't know how much you are taking. Why exactly are they using a syringe anyway? OMG he is using a 1/2" needle. If he injected like that he would hit muscle as it's a long needle, he should pinch up and go in at an angle. Better yet he should just use a 4mm needle then he could inject like that.

Someone desperately needs to put a decent picture of a modern pen needle into the public domain. Something more like this 4mm needle (1/3rd the length of the one in the article):

Lots of PWD disagree with you as well, here's a few of them (and some are using 4mm needles!):

• insulin pen injections are painful

• Painful Insulin Injections

• Injecting hurts

• How to avoid pain while injecting the insulin injection ?

• Pain with injection

[comnkd]

Jun 13, 2017 16:43:03 GMT -5 agedhippie said:

Jun 13, 2017 15:33:13 GMT -5 mango said:

health.usnews.com/health-care/patient-advice/articles/2017-06-13/how-does-insulin-work


• Take away:

—The people that contributed to this article are either not educating themselves or are paid shills. There is just no other explanation for this.

—Mr. Sisson is lying through his teeth when he says insulin pens are harmless and cause no pain. 

—There is zero mention of the positives with using Afrezza, only the fact that it cannot be used in asthmatics and COPDers and the fact it must be used in conjunction with along acting insulin is mentioned. 

—Serious negative side-effects from using insulin injections (which include "pens") are mentioned and brushed aside as if it is less worrisome than using the new inhaled insulin that would actually eliminate many of these potential side effects. 

—Paid shills. 

• If anyone else wants to contact the Pharmacist that commented on Afrezza and properly educate him then his phone number and email are in the link below:

Evan M. Sisson, Pharm.D., MSHA, BCACP, CDE, FAADE

app.pharmacy.vcu.edu/faculty/facdetail.aspx?id=74

That's your opinion and you are entitle to it but it doesn't make it correct. I have injected for decades and don't have lipohypertrophy. Nor do modern pen needles hurt in the my opinion and that of the other diabetics I know. There are thicker acupuncture needles!

I do agree that some of his points are silly - washing your hands before you inject? Why exactly since you don't touch the injection site or the needle? Personally I inject straight through my clothes and there was even a study to see if that was bad and it's only finding was that if the cloth was thick it may slightly blunt the needle but there was no infection risk.

As usual the picture is a joke. There is a bubble in the syringe so you don't know how much you are taking. Why exactly are they using a syringe anyway? OMG he is using a 1/2" needle. If he injected like that he would hit muscle as it's a long needle, he should pinch up and go in at an angle. Better yet he should just use a 4mm needle then he could inject like that.

Someone desperately needs to put a decent picture of a modern pen needle into the public domain. Something more like this 4mm needle (1/3rd the length of the one in the article):

Or you just 1. Click, 2. Snap and 3. Inhale.

[agedhippie]

Jun 13, 2017 21:00:04 GMT -5 comnkd said:

Jun 13, 2017 16:43:03 GMT -5 agedhippie said:

Someone desperately needs to put a decent picture of a modern pen needle into the public domain. Something more like this 4mm needle (1/3rd the length of the one in the article):

Or you just 1. Click, 2. Snap and 3. Inhale.

Or you just 1. Attach, 2. Prod, 3. Squeeze.   

[agedhippie]

Jun 13, 2017 17:09:00 GMT -5 mango said:

Lots of PWD disagree with you as well, here's a few of them (and some are using 4mm needles!):

• insulin pen injections are painful

• Painful Insulin Injections

• Injecting hurts

• How to avoid pain while injecting the insulin injection ?

• Pain with injection

What can I say? Yes some people have pain but in a straw poll of the fifty or so Type 1s I know nobody thinks needles hurt. Finger sticks yes, insulin shots no. I will read the links though.

Just got in with an edit! Some of those people are refrigerating their insulin and that can hurt - they just shouldn't do it. Others are talking about Lantus which is acidic can can sting briefly as well. It comes down to the insulin rather than the needle for the most part. 

[sayhey24]

Jun 13, 2017 21:53:51 GMT -5 agedhippie said:

Jun 13, 2017 17:09:00 GMT -5 mango said:

Lots of PWD disagree with you as well, here's a few of them (and some are using 4mm needles!):

• insulin pen injections are painful

• Painful Insulin Injections

• Injecting hurts

• How to avoid pain while injecting the insulin injection ?

• Pain with injection

What can I say? Yes some people have pain but in a straw poll of the fifty or so Type 1s I know nobody thinks needles hurt. Finger sticks yes, insulin shots no. I will read the links though.

Just got in with an edit! Some of those people are refrigerating their insulin and that can hurt - they just shouldn't do it. Others are talking about Lantus which is acidic can can sting briefly as well. It comes down to the insulin rather than the needle for the most part. 

Whether we like it or not injections for basal are here to stay for a long time.  The only other option is a pump.  However, with Tresiba and Toujeo combined with afrezza the pumps have been obsoleted.

For meal time, some of the ADA meetings pretty much summed it up.  Nothing better than afrezza but its got a few obstacles with cost #1.  Hopefully Mike was listening.

Another take away was the dream of CGMs and knowing BG numbers has now become a reality and now there is no hiding the numbers and nothing is better than afrezza at meal time.  As Steve Edelman said we don't need new drugs, we just need to start using the drugs we have.

That IMO was a very bold statement by Dr. Edelman and should have made National headlines.  Mike IMO now needs a bold plan for addressing cost and DTC product delivery.  Hopefully Dachis is working on both.